October 2016

Editorial Board
Published in issue: October 2016
IFC

Table of Contents
Published in issue: October 2016
iii-iv

Editorial

Clinical epidemiological research in lower-income countries faces specific methodological challenges
• J. André Knottnerus,
• Peter Tugwell
Published in issue: October 2016
p1-3

Controversy and Debate

Are regression “nomograms” useful?
• Roger J. Marshall
Published online: April 06, 2016
p4-6

Response to the commentary on “A nomogram was developed to enhance the use of multinomial logistic regression modelling in diagnostic research”
• Johannes B. Reitsma,
• Maarten van Smeden,
• Joris A.H. de Groot,
• Loes C.M. Bertens,
• Karel G.M. Moons
Published online: March 30, 2016
p7-9

Reviews

Comparative rates of harms in randomized trials from more developed versus less developed countries may be different
• Despina Contopoulos-Ioannidis,
• Xanthippi Tseretopoulou,
• Megan Ancker,
• ...
• Orestis A. Panagiotou,
• Yvonne Maldonado,
• John P.A. Ioannidis
Published online: April 05, 2016
p10-21

Outcomes in systematic reviews of complex interventions never reached “high” GRADE ratings when compared with those of simple interventions
• Ani Movsisyan,
• G.J. Melendez-Torres,
• Paul Montgomery
Published online: March 30, 2016
p22-33

High quality of the evidence for medical and other health-related interventions was uncommon in Cochrane systematic reviews
• Padhraig S. Fleming,
• Despina Koletsi,
• John P.A. Ioannidis,
• Nikolaos Pandis
Published online: March 28, 2016
p34-42

Inadequate critical appraisal of studies in systematic reviews of time to diagnosis
• Elise Launay,
• Jérémie F. Cohen,
• Michèle Morfouace,
• Christèle Gras-Le Guen,
• Philippe Ravaud,
• Martin Chalumeau
Published online: March 30, 2016
p43-51

Active recruitment and limited participant-load related to high participation in large population-based biobank studies
• Sander K.R. van Zon,
• Salome Scholtens,
• Sijmen A. Reijneveld,
• Nynke Smidt,
• Ute Bültmann
Published online: March 28, 2016
p52-62

A systematic review of quality of thyroid-specific health-related quality-of-life instruments recommends ThyPRO for patients with benign thyroid diseases
• Carlos K.H. Wong,
• Brian H.H. Lang,
• Cindy L.K. Lam
Published online: March 25, 2016
p63-72

Original Articles

Partial verification bias and incorporation bias affected accuracy estimates of diagnostic studies for biomarkers that were part of an existing composite gold standard
• Annika Karch,
• Armin Koch,
• Antonia Zapf,
• Inga Zerr,
• André Karch
Published online: April 20, 2016
p73-82

Modern modeling techniques had limited external validity in predicting mortality from traumatic brain injury
• Tjeerd van der Ploeg,
• Daan Nieboer,
• Ewout W. Steyerberg
Published online: March 14, 2016
p83-89

Explicit inclusion of treatment in prognostic modeling was recommended in observational and randomized settings
• Rolf H.H. Groenwold,
• Karel G.M. Moons,
• Romin Pajouheshnia,
• ...
• Johannes B. Reitsma,
• Richard D. Riley,
• Linda M. Peelen
Published online: April 01, 2016
p90-100

The lag-time approach improved drug–outcome association estimates in presence of protopathic bias
• Andrea Arfè,
• Giovanni Corrao
Published online: March 11, 2016
p101-107

Complementary approaches to searching MEDLINE may be sufficient for updating systematic reviews
• Margaret Sampson,
• Berry de Bruijn,
• Christine Urquhart,
• Kaveh Shojania
Published online: March 11, 2016
p108-115

Changing definitions altered multimorbidity prevalence, but not burden associations, in a musculoskeletal population
• Dianne Lowe,
• Michael Taylor,
• Sophie Hill
Published online: March 29, 2016
p116-126
Open Access

Letters to the Editor

Re: “using data sources beyond PubMed has a modest impact on the results of systematic reviews of therapeutic interventions”
• Jan W. Schoones,
• Thomas Vissers
Published online: April 25, 2016
p127
Beyond the corrupting influence of pharmaceutical companies on antidepressant meta-analyses (Letter commenting on: J Clin Epidemiol. 70, 2016, 155−163)
• Jose de Leon
Published online: March 14, 2016
p127-128
Many continuous variables such as the duration of the common cold should be analyzed using the relative scale
• Harri Hemilä
Published online: April 06, 2016
p128-129