STROBE Reporting Tool
- Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change susceptibility and clinical outcomes are used as proxies for investigating the interactions between external and/or endogenous agents and body components or processes. The need for improved reporting of scientific research led to influential statements of recommendations such as the STrengthening Reporting of OBservational studies in Epidemiology (STROBE) statement.
- Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence, the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association (STREGA) studies initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement and provides additions to 12 of the 22 items on the STROBE checklist.
- The first acronym in the title, STREGA (Strengthening the Reporting of Genetic Association studies), is the latest scion on the growing tree of publication guidelines, and is published in this issue of the Journal of Clinical Epidemiology and in several other journals . Most readers of this journal will recognize at least one of the acronyms—all are publication guidelines for diverse types of studies. The list is far from complete, and a cynic might be forgiven for thinking that there are now so many publication guidelines that nobody can keep track of, and that they will all sink quietly into oblivion.
- We encourage readers of JCE to read the short paper , which is published in this issue of the Journal of Clinical Epidemiology as well as in a number of other journals describing the new checklist for reporting of observational studies in epidemiology.
- Much of biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalizability. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included in an accurate and complete report of an observational study. We defined the scope of the recommendations to cover three main study designs: cohort, case–control, and cross-sectional studies.