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  • AHRQ Series Part II: Methods Guide for Comparative Effectiveness - Guest Editor, Mark Helfand

    Conducting quantitative synthesis when comparing medical interventions: AHRQ and the Effective Health Care Program

    Journal of Clinical Epidemiology
    Vol. 64Issue 11p1187–1197Published online: April 8, 2011
    • Rongwei Fu
    • Gerald Gartlehner
    • Mark Grant
    • Tatyana Shamliyan
    • Art Sedrakyan
    • Timothy J. Wilt
    • and others
    Cited in Scopus: 320
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      This article is to establish recommendations for conducting quantitative synthesis, or meta-analysis, using study-level data in comparative effectiveness reviews (CERs) for the Evidence-based Practice Center (EPC) program of the Agency for Healthcare Research and Quality.
    • Review Article

      AHRQ Series Paper 4: Assessing harms when comparing medical interventions: AHRQ and the Effective Health-Care Program

      Journal of Clinical Epidemiology
      Vol. 63Issue 5p502–512Published online: September 29, 2008
      • Roger Chou
      • Naomi Aronson
      • David Atkins
      • Afisi S. Ismaila
      • Pasqualina Santaguida
      • David H. Smith
      • and others
      Cited in Scopus: 126
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        Comparative effectiveness reviews (CERs) are systematic reviews that evaluate evidence on alternative interventions to help clinicians, policy makers, and patients make informed treatment choices. Reviews should assess harms and benefits to provide balanced assessments of alternative interventions. Identifying important harms of treatment and quantifying the magnitude of any risks require CER authors to consider a broad range of data sources, including randomized controlled trials (RCTs) and observational studies.
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