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  • Review Article

    AHRQ Series Paper 4: Assessing harms when comparing medical interventions: AHRQ and the Effective Health-Care Program

    Journal of Clinical Epidemiology
    Vol. 63Issue 5p502–512Published online: September 29, 2008
    • Roger Chou
    • Naomi Aronson
    • David Atkins
    • Afisi S. Ismaila
    • Pasqualina Santaguida
    • David H. Smith
    • and others
    Cited in Scopus: 127
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      Comparative effectiveness reviews (CERs) are systematic reviews that evaluate evidence on alternative interventions to help clinicians, policy makers, and patients make informed treatment choices. Reviews should assess harms and benefits to provide balanced assessments of alternative interventions. Identifying important harms of treatment and quantifying the magnitude of any risks require CER authors to consider a broad range of data sources, including randomized controlled trials (RCTs) and observational studies.
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