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Systematic reviews and meta-analyses that include registry-based studies: methodological challenges and areas for future research

  • Tim Mathes
    Affiliations
    Institute for Medical Statistics, University Medical Center Goettingen, Humboldtallee 32, 37073, Goettingen
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  • Zhentian Zhang
    Correspondence
    Corresponding author. Institute for Medical Statistics, University Medical Center Goettingen, Humboldtallee 32, 37073, Goettingen, Tel.: +49-1525-4108769; fax: +49-0551-394995.
    Affiliations
    Institute for Medical Statistics, University Medical Center Goettingen, Humboldtallee 32, 37073, Goettingen
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  • Alexander Pachanov
    Affiliations
    Faculty of Health Sciences Brandenburg, Brandenburg Medical School (Theodor Fontane), Institute for Health Services and Health System Research, Rüdersdorf, Germany

    Center for Health Services Research, Brandenburg Medical School (Theodor Fontane), Rüdersdorf, Germany
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  • Dawid Pieper
    Affiliations
    Faculty of Health Sciences Brandenburg, Brandenburg Medical School (Theodor Fontane), Institute for Health Services and Health System Research, Rüdersdorf, Germany

    Center for Health Services Research, Brandenburg Medical School (Theodor Fontane), Rüdersdorf, Germany
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Published:February 16, 2023DOI:https://doi.org/10.1016/j.jclinepi.2023.02.014
      There are many challenges (eg, overlapping observations) that are more common–although not unique–in a systematic review (SR) that includes studies, which are based on routinely collected data (e.g., registries) compared to a SR, which only includes randomized trials or studies that are based on data specifically collected for these studies.
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