- •We found a rapid increase in platform trials since the last review, coinciding with the COVID-19 pandemic.
- •Platform trials have now been utilised in more diverse areas of medicine, whereas it was previously dominated by oncology and infectious diseases.
- •We provide the most updated review of platform trials to-date, including methodological aspects of platform trials and also provide readers with an introduction to platform trials by the way of examples throughout the paper.
- •As platform trials become more prevalent, this review can help clinicians and researchers understand platform trials and compare the different approaches taken by successful and unsuccessful models.
Publication stageIn Press Journal Pre-Proof
Contributions: TP, DZ and BR conceived the study idea. SC, EC, NK, GL, RV, and JM helped collect screen and collect data. CY, EG, SM, AH and BR provided content expertise. BR and DZ contributed equally to supervising the study. TP is the data guarantor.
Declaration of interests
☐ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
☒ The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:
Tyler Pitre reports financial support was provided by McMaster University.