- -Adaptive clinical trials are flexible and adaptive features may increase trial efficiency and individual participants’ chances of being allocated to superior interventions.
- -Adaptive trials come with increased complexity and not all adaptive features may always be beneficial.
- -We provide an overview of and guidance on key methodological considerations for clinical trials employing adaptive stopping, adaptive arm dropping, or response-adaptive randomisation.
- -Further, we provide, a simulation engine and example on how to compare adaptive trial designs using simulation is provided.
- -This guidance paper may help trialists designing and planning adaptive clinical trials.
Study Design and Setting
Publication stageIn Press Journal Pre-Proof
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