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Strong and high-quality evidence synthesis needs Cochrane: a statement of support by the GRADE Guidance Group

  • Holger J. Schünemann
    Correspondence
    Corresponding author. Department of Health Research Methods, Evidence and Impact, McMaster University, HSC-2C, 1280 Main Street West, Hamilton, Ontario L8N 3Z5, Canada. Tel.: +1 905 525 9140 x 24931.
    Affiliations
    Department of Health Research Methods, Evidence, and Impact, Hamilton, Ontario, Canada

    Michael G. DeGroote, Cochrane Canada & McMaster GRADE Centres, McMaster University, Hamilton, Ontario, Canada

    Institute for Evidence in Medicine, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
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  • Sue Brennan
    Affiliations
    School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
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  • Marina Davoli
    Affiliations
    Department of Epidemiology Lazio Region, Via Cristoforo Colombo 112, 00147
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  • Reem A. Mustafa
    Affiliations
    Department of Medicine, University of Kansas Medical Center, Kansas City, KS, USA
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  • Elie A. Akl
    Affiliations
    Department of Health Research Methods, Evidence, and Impact, Hamilton, Ontario, Canada

    Department of Internal Medicine, American University of Beirut Medical Center, P.O.Box 11-0236/CRI (E15), Riad-El-Solh, Beirut 1107 2020, Lebanon
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  • Joerg J. Meerpohl
    Affiliations
    Michael G. DeGroote, Cochrane Canada & McMaster GRADE Centres, McMaster University, Hamilton, Ontario, Canada

    Cochrane Germany, Cochrane Germany Foundation, Freiburg, Germany
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  • Signe Flottorp
    Affiliations
    Division for Health Services, Norwegian Institute of Public Health, Oslo, Norway

    Institute of Health and Society, University of Oslo, Oslo, Norway
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  • Maria Ximena Rojas
    Affiliations
    Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau-CIBERESP), Barcelona 08025, Spain
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  • Gordon Guyatt
    Affiliations
    Department of Health Research Methods, Evidence, and Impact, Hamilton, Ontario, Canada

    Institute for Evidence in Medicine, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Miranda Langendam
    Affiliations
    Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health institute, Amsterdam, The Netherlands
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  • Pablo Alonso Coello
    Affiliations
    Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau-CIBERESP), Barcelona 08025, Spain
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  • Philipp Dahm
    Affiliations
    Department of Urology, University of Minnesota, Minneapolis VA Health Care System, Minneapolis, MN, USA
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      Highlights

      • Cochrane is widely recognized for its pioneering efforts in promoting and producing high-quality systematic reviews as the basis of evidence-based decision-making and advancing the underlying methods of evidence synthesis.
      • The GRADE Working Group has developed the most widely used approach to rating the certainty of evidence to ensure that users of the reviews understand how much trust to put in findings of research and to then use this evidence for decision making.
      • For decades, both organizations have been closely aligned through their mutual goal of providing trustworthy healthcare related information to allow individuals, guideline developers, and policy makers to make decisions grounded in evidence.
      • Beyond the concepts of SoF table, the joint experience in rating the certainty of evidence and the application of GRADE in Cochrane reviews strengthened the reviews and GRADE's conceptual developments, and ultimately becoming the internationally accepted approach for rating certainty of evidence.
      • The work of the two groups is also aligned with the mission of the Journal of Clinical Epidemiology's (JCE) promotion of the quality of clinical and patient-oriented health care research. These alignments are one of the reasons for submitting this commentary to the JCE in support of Cochrane.
      • A strong Cochrane is not only in the interest of GRADE and the entire evidence-based healthcare community, but also of the future of trusted evidence, informed decisions, and a better health.
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