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Reporting of funding and conflicts of interest improved from preprints to peer-reviewed publications of biomedical research

      Abstract

      Background and Objectives

      To assess changes in the reporting of funding and conflicts of interest (COI) in biomedical research between preprint server publications and their corresponding versions in peer-reviewed journals.

      Methods

      We selected preprint servers publishing exclusively biomedical research. From these, we screened articles by order of publication date and identified 200 preprints first published in 2020 with subsequent versions in peer-reviewed journals. We judged eligibility and extracted data about authorship, funding, and COI in duplicate and independently. We performed descriptive statistics.

      Results

      A quarter of the studies added at least one author to the peer-reviewed version. Most studies reported funding in both versions (87%), and a quarter of these added at least one funder to the peer-reviewed version. Eighteen studies (9%) reported funding only in the peer-reviewed version. A majority of studies reported COI in both versions (69%) and 5% of these had authors reporting more COI in the peer-reviewed version. A minority of studies (23%) reported COI only in the peer-reviewed version. None of the studies justified any changes in authorship, funding, or COI.

      Conclusion

      Reporting of funding and COI improved in peer-reviewed versions. However, substantive percentages of studies added authors, funders, and COI disclosures in their peer-reviewed versions.

      Keywords

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      References

        • MedRxiv
        About medRxiv.
        (Available at)
        • Massey D.S.
        • Opare M.A.
        • Wallach J.D.
        • Ross J.S.
        • Krumholz H.M.
        Assessment of preprint policies of top-ranked clinical journals.
        JAMA Netw Open. 2020; 3: e2011127
        • Watson C.
        Rise of the preprint: how rapid data sharing during COVID-19 has changed science forever.
        Nat Med. 2022; 28: 2-5
        • Fraser N.
        • Brierley L.
        • Dey G.
        • Polka J.K.
        • Pálfy M.
        • Nanni F.
        • et al.
        The evolving role of preprints in the dissemination of COVID-19 research and their impact on the science communication landscape.
        PLoS Biol. 2021; 19: e3000959
      1. Rustan E. Use of preprint in the publication of the scientific papers. Journal of physics: conference series. IOP Publishing, Makassar, Indonesia2021
        • Elsevier
        What are conflicts of interest/competing interests, declaration of interest statements, funding source declaration, author agreements/declaration and permission notes?.
        (Available at)
        • Institute of Medicine (US)
        Committee on conflict of interest in medical research E, and practice. Conflict of interest in medical research, education, and practice.
        National Academies Press (US), Washington, DC2009
        • Carneiro C.F.
        • Queiroz V.G.
        • Moulin T.C.
        • Carvalho C.A.
        • Haas C.B.
        • Rayêe D.
        • et al.
        Comparing quality of reporting between preprints and peer-reviewed articles in the biomedical literature.
        Res Integrity Peer Rev. 2020; 5: 1-19
        • Bero L.
        • Lawrence R.
        • Leslie L.
        • Chiu K.
        • McDonald S.
        • Page M.J.
        • et al.
        Cross-sectional study of preprints and final journal publications from COVID-19 studies: discrepancies in results reporting and spin in interpretation.
        BMJ Open. 2021; 11: e051821
        • Hamade L.
        • Ali A.
        • Hijazi A.R.
        • Itani D.
        • Al Habob H.
        • Lababidi G.
        • et al.
        Policies of biomedical preprint servers on conflicts of interest, authorship, and research integrity lacked important details.
        J Clin Epidemiol. 2022; 146: 47-59
        • Daou K.N.
        • Hakoum M.B.
        • Khamis A.M.
        • Bou-Karroum L.
        • Ali A.
        • Habib J.R.
        • et al.
        Public health journals’ requirements for authors to disclose funding and conflicts of interest: a cross-sectional study.
        BMC Public Health. 2018; 18: 1-9
        • El Moheb M.
        • Karam B.S.
        • Assi L.
        • Armache M.
        • Khamis A.M.
        • Akl E.A.
        The policies for the disclosure of funding and conflict of interest in Surgery journals: a cross-sectional survey.
        World J Surg. 2021; 45: 97-108
        • Khamis A.M.
        • Hakoum M.B.
        • Bou-Karroum L.
        • Habib J.R.
        • Ali A.
        • Guyatt G.
        • et al.
        Requirements of health policy and services journals for authors to disclose financial and non-financial conflicts of interest: a cross-sectional study.
        Health Res Pol Syst. 2017; 15: 1-8
        • Shawwa K.
        • Kallas R.
        • Koujanian S.
        • Agarwal A.
        • Neumann I.
        • Alexander P.
        • et al.
        Requirements of clinical journals for authors’ disclosure of financial and non-financial conflicts of interest: a cross sectional study.
        PLoS One. 2016; 11: e0152301
        • Hakoum M.B.
        • Bou-Karroum L.
        • Al-Gibbawi M.
        • Khamis A.M.
        • Raslan A.S.
        • Badour S.
        • et al.
        Reporting of conflicts of interest by authors of primary studies on health policy and systems research: a cross-sectional survey.
        BMJ Open. 2020; 10: e032425
        • Khamis A.M.
        • Bou-Karroum L.
        • Hakoum M.B.
        • Al-Gibbawi M.
        • Habib J.R.
        • El-Jardali F.
        • et al.
        The reporting of funding in health policy and systems research: a cross-sectional study.
        Health Res Policy Syst. 2018; 16: 1-8
      2. List of preprint servers: policies and practices across platforms: ASAPbio.
        (Available at)
        https://asapbio.org/preprint-servers
        Date: 2021
        Date accessed: July 11, 2021
        • Harris P.A.
        • Taylor R.
        • Minor B.L.
        • Elliott V.
        • Fernandez M.
        • O'Neal L.
        • et al.
        The REDCap consortium: building an international community of software platform partners.
        J Biomed Inform. 2019; 95: 103208
        • Harris P.A.
        • Taylor R.
        • Thielke R.
        • Payne J.
        • Gonzalez N.
        • Conde J.G.
        Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support.
        J Biomed Inform. 2009; 42: 377-381
        • Brierley L.
        • Nanni F.
        • Polka J.K.
        • Dey G.
        • Pálfy M.
        • Fraser N.
        • et al.
        Tracking changes between preprint posting and journal publication during a pandemic.
        PLoS Biol. 2022; 20: e3001285
        • Oikonomidi T.
        • Boutron I.
        • Pierre O.
        • Cabanac G.
        • Ravaud P.
        Changes in evidence for studies assessing interventions for COVID-19 reported in preprints: meta-research study.
        BMC Med. 2020; 18: 1-10
      3. ICMJE. Overlapping.
        (Available at)