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Funding: No external funding.
Ethical approval: Not applicable.
Competing interest statement: All authors declare they did not receive support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years exist nor do other relationships or activities that could appear to have influenced the submitted work. All authors are members of the GRADE working group.
Authors’ contributions: All authors contributed to the generation of the research hypothesis, participated to the discussion of its content, and approved the final version of the article. F.F., V.Z., and A.I. selected the systematic reviews used as examples and prepared summary of finding tables used in the process. F.F. drafted the article, and A.I. is the guarantor.
Data sharing: No additional data available.