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Funding: The first author (C.H.) was funded by the TAILORED-Treatment study, which received funding from the EU's Seventh Framework Program FP7 under REA grant agreement No. HEALTH-F3–602860-2013 (TAILORED-Treatment; www.tailored-treatment.eu/).
Conflict of interest statement: The authors have no conflicts of interest relevant to this article to disclose.
Authors' contributions: All authors were responsible for the design of the study. C.H., L.A., S.A., W.A., I.C., T.C., A.G., I.G., A.G., D.G., I.I., A.K., L.L., Y.L., F.L., C.M., S.M., B.N., C.P., A.R., H.R., M.S., R.T., T.T., V.U., W.W., S.W., J.W., K.W., T.W., N.M., L.S., and L.B. performed the experiments. All authors interpreted the data. C.H., C.N., N.M., T.G., A.C., K.O., E.E., P.F., L.S., and L.B. analyzed the data. All authors were responsible for writing and/or critically revisions of the article.