Study Design and Setting
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Conflict of interest: The authors have declared that no conflict of interest exists.
Competing interests: A.C.T. is an associate editor, and S.E.S. is on the policy advisory board for the journal; all other authors do not have any conflicts of interest to declare.
Funding: This work was supported by an Ontario Ministry of Research, Innovation, and Science Early Researcher Award that was awarded to A.C.T. S.E.S. is funded by a Tier 1 Canada Research Chair in Knowledge Translation, and A.C.T. is funded by a Tier 2 Canada Research Chair in Knowledge Synthesis. The funders had no role in the design and conduct of the study; data collection, analysis, and interpretation of data; writing of the report; and in the decision to submit the article for publication.
Authors' contributions: E.R., J.I., A.C.T., and B.P. made substantial contributions to the conception and design, acquisition of data, and analysis and interpretation of data. S.E.S. made substantial contributions to conception and design, and analysis and interpretation of data. R.R. made substantial contributions to analysis and interpretation of data, and led the writing of the manuscript. All authors were involved in the drafting and revision of the manuscript and gave final approval of the version submitted for publication.
Authors' information: Dr. E.R. is a third-year internal medicine resident at Queen's University in Kingston, Ontario. Dr. E.R. contributed to this project as part of a research component of her core internal medicine training. She is a graduate of McGill University's medical school. Dr. E.R. also completed an undergraduate and doctorate degree in Pharmacy at the University of Toronto. She practiced as a primary care pharmacist at Two Rivers Family Health Team in Cambridge, Ontario. Dr. E.R. has experience in systematic review, rapid review, and network meta-analysis methodology. She worked as a clinical research officer for the Canadian Agency for Drugs and Technologies in Health. Emily has worked as a research coordinator at the Li Ka Shing Knowledge Institute of St. Michael's Hospital since March of 2013. Mr. R.R. has a Masters of Mathematics from the University of Waterloo and has substantial experience in the design and analysis of clinical trials and health economic data as well as medical writing. Mr. R.R is a biostatistician and part-time research associate at Li Ka Shing Knowledge Institute. Mr. J.I. graduated from the National University of Ireland (Galway) with a BSc in Biochemistry and a MSc in Neuropharmacology. He worked for three years as a clinical research coordinator in the Wound Care Clinic of Dr. R. Gary Sibbald in Mississauga, Ontario and has been working with the Li Ka Shing Institute since January 2013, where he has gained experience in systematic review, rapid review, and network meta-analysis methodologies. Mr. J.H. is a PhD student in the Epidemiology Division at the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. He is funded by the Frederick Banting and Charles Best Canada Graduate Scholarship Doctoral Award from the Canadian Institutes for Health Research. Dr. B.P. is a research associate, health economist, decision modeler, systematic review methodologist, and biostatistician. Dr. S.E.S. is a geriatrician, clinical epidemiologist and professor, and director of the Knowledge Translation Program of St. Michael's Hospital and of Geriatric Medicine at the University of Toronto. She holds a Tier 1 Canada Research Chair in Knowledge Translation, has been awarded more than $30 million in peer-reviewed grants in the past 10 years and has published >350 peer-reviewed publications. Dr. A.C.T. is a Scientist at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Associate Professor in the Epidemiology Division of the Dalla Lana School of Public Health, University of Toronto and holds a Tier 2 Canada Research Chair in Knowledge Synthesis and an Ontario Ministry of Research, Innovation, and Science Early Researcher Award.