Pragmatic trials aim to inform a health care decision, whereas explanatory trials
focus on understanding [
[1]
]. As a consequence, pragmatic trials are undertaken under conditions very similar
to the usual care setting, whereas explanatory trials are undertaken under ideal conditions
to maximize success.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Clinical EpidemiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Explanatory and pragmatic attitudes in therapeutical trials.J Chronic Dis. 1967; 20 ([reprinted in this issue; J Clin Epidemiol 2009;62:499–505]): 637-648
- A new “Mechanistic-Practical” framework for designing and interpreting randomized trials.J Clin Epidemiol. 2009; 62 ([in this issue]): 479-484
- Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy.JAMA. 2003; 290: 1624-1632
- Users' guides to the medical literature: XIV. How to decide on the applicability of clinical trial results to your patient. Evidence-Based Medicine Working Group.JAMA. 1998; 279: 545-549
- Schünemann and for the GRADE Working Group. What is “quality of evidence” and why is it important to clinicians?.BMJ. 2008; 336: 995-998
- What are pragmatic trials?.BMJ. 1998; 316: 285
- Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity.BMC Med Res Methodol. 2003; 3: 28
- Explanatory versus management trials.in: Haynes R.B. Sackett D.L. Guyatt G.H. Tugwell P. Clinical epidemiology: how to do clinical practice research. Lippincott, Williams and Wilkins, Philadelphia, PA2006
- A pragmatic-exlanatory continuum indicator summary (PRECIS): a tool to help trial designers.J Clin Epidemiol. 2009; 62 ([in this issue]): 464-475
Article info
Publication history
Accepted:
August 31,
2008
Identification
Copyright
© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
