Commentary| Volume 62, ISSUE 5, P485-488, May 2009

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Why we will remain pragmatists: four problems with the impractical mechanistic framework and a better solution

      Pragmatic trials aim to inform a health care decision, whereas explanatory trials focus on understanding [
      • Schwartz D.
      • Lellouch J.
      Explanatory and pragmatic attitudes in therapeutical trials.
      ]. As a consequence, pragmatic trials are undertaken under conditions very similar to the usual care setting, whereas explanatory trials are undertaken under ideal conditions to maximize success.
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