Abstract
Making sense of rapidly evolving evidence on genetic associations is crucial to making
genuine advances in human genomics and the eventual integration of this information
in the practice of medicine and public health. Assessment of the strengths and weaknesses
of this evidence, and hence, the ability to synthesize it, has been limited by inadequate
reporting of results. The STrengthening the REporting of Genetic Association (STREGA)
studies initiative builds on the Strengthening the Reporting of Observational Studies
in Epidemiology (STROBE) statement and provides additions to 12 of the 22 items on
the STROBE checklist. The additions concern population stratification, genotyping
errors, modeling haplotype variation, Hardy–Weinberg equilibrium, replication, selection
of participants, rationale for choice of genes and variants, treatment effects in
studying quantitative traits, statistical methods, relatedness, reporting of descriptive
and outcome data, and the volume of data issues that are important to consider in
genetic association studies. The STREGA recommendations do not prescribe or dictate
how a genetic association study should be designed, but seek to enhance the transparency
of its reporting, regardless of choices made during design, conduct, or analysis.
Keywords
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Article info
Publication history
Published online: February 17, 2009
Accepted:
December 29,
2008
Footnotes
To encourage dissemination of the Strengthening the Reporting of Genetic Association statement, this article has also been published by Annals of Internal Medicine, European Journal of Clinical Investigation, European Journal of Epidemiology, Genetic Epidemiology, Human Genetics, and PLoS Medicine. The authors jointly hold the copyright of this article, except for two US Federal Government employees (M.G. and M.J.K.) for whom copyright is held by the US government.
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Copyright
© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
