Abstract
Objective
To assess the cross-sectional construct validity of the Health Utilities Index Mark
3 (HUI3) in Alzheimer disease (AD), arthritis (AR), and cataracts (CA).
Study Design and Setting
The 1996–97 Canadian National Population Health Survey for community and institution-dwelling
respondents aged 40 years and above was used in the study. Adjusted means for overall
and single-attribute HUI3 scores of five subgroups were compared: (1) AD only, (2)
AR only, (3) CA only, (4) at least two of the three conditions, and (5) none of the
three (reference group). Regression analyses were conducted for community and institutional
data to obtain adjusted mean utility scores.
Results
Of the 76 a priori hypotheses, 55 were confirmed. HUI3 was able to describe overall burdens of AD, AR,
and CA as well as vision problems associated with CA, speech and cognition problems
associated with AD, and ambulation and pain problems associated with AR. Adjusted
mean differences in overall HUI3 scores between AD, AR, or CA only groups and reference
group ranged from −0.04 to −0.42 (P<0.05); all differences were quantitatively important.
Conclusion
HUI3 is useful in assessing the health-related quality of life of AD, AR, and CA of
those living in the community and institutions.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Clinical EpidemiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Multiattribute and single-attribute utility functions for the health utilities index mark 3 system.Med Care. 2002; 40: 113-128
- Health Utilities Index Mark 3: evidence of construct validity for stroke and arthritis in a population health survey.Med Care. 2000; 38: 290-299
- Health Utilities Index mark 3 demonstrated construct validity in a population-based sample with type 2 diabetes.J Clin Epidemiol. 2006; 59: 472-477
- Utility scores for chronic conditions in a community-dwelling population.Pharmacoeconomics. 1999; 15: 369-376
- Impact of chronic conditions.Health Rep. 2003; 14: 41-53
- Assessing health-related quality of life in cataract patients: the relationship between utility and health-related quality of life measurement.Qual Life Res. 2000; 9: 1127-1135
- National Population Health Survey: health institutions 1996–97 public use microdata files.(Available at) (accessed Oct. 25, 2007)
- National Population Health Survey: household 1996–97 public use microdata file—health.(Available at) (accessed Oct. 25, 2007)
- Introducing economic and quality of life measurements into clinical studies.Ann Med. 2001; 33: 344-349
- Producing health, consuming health care.Soc Sci Med. 1990; 31: 1347-1363
- Analysis of health surveys.John Wiley & Sons Inc., New York1999
- Bootstrap variance estimation for the National Population Health Survey. Proceedings of the Annual Meeting of the American Statistical Association: Survey Research Methods Section, August 1999.American Statistical Association, Baltimore, MD1999
- SAS 9.1.([computer program]) SAS Institute Inc., Cary NC2003
- SUDAAN 9.0.1.([computer program] Research Triangle Park) Research Triangle Institute, NC2005
- Patient versus informant perspectives of Quality of Life in Mild Cognitive Impairment and Alzheimer's disease.Int J Geriatr Psychiatry. 2004; 19: 256-265
- Undetected dementia in community-dwelling older people: the Canadian Study of Health and Aging.J Am Geriatr Soc. 2000; 48: 1430-1434
- Estimating the prevalence of dementia in elderly people: a comparison of the Canadian Study of Health and Aging and National Population Health Survey approaches.Int Psychogeriatr. 2001; 13: 169-175
- Does it matter whom and how you ask? inter- and intra-rater agreement in the Ontario Health Survey.J Clin Epidemiol. 1997; 50: 127-135
- Reported activities of daily living: agreement between elderly subjects with and without dementia and their caregivers.Age Ageing. 1997; 26: 99-106
- The use of the Tobit model for analyzing measures of health status.Qual Life Res. 2000; 9: 901-910
Article info
Publication history
Published online: March 25, 2008
Accepted:
September 23,
2007
Footnotes
David Feeny has a proprietary interest in Health Utilities Incorporated (HUInc), Dundas, Ontario, Canada. HUInc. distributes copyrighted Health Utilities Index (HUI) materials and provides methodological advice on the use of HUI. It should be noted that HUInc. received no payment for the use of HUI in the study reported in this manuscript. None of the other authors declare any conflict of interest.
The research and analysis reported in this paper are based on data from Statistics Canada and the opinions expressed do not represent the views of Statistics Canada.
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
