In this issue, Bassler et al. [
] provide a good review of some of the dangers of stopping clinical trials early for benefit, including a likely overestimation of the true treatment effect.
- Bassler D.
- Montori V.M.
- Briel M.
- Glasziou P.
- Guyatt G.
Early stopping of randomised clinical trials for overt efficacy is problematic.
J Clin Epidemiol. 2008; 61: 241-246
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- Early stopping of randomised clinical trials for overt efficacy is problematic.J Clin Epidemiol. 2008; 61: 241-246
- Randomized trials stopped early for benefit: a systematic review.J Am Med Assoc. 2005; 294: 2203-2209
Published online: January 07, 2008
Accepted: August 3, 2007
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.