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Invited Commentary| Volume 61, ISSUE 3, P203-204, March 2008

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Interim monitoring of efficacy data is important and appropriate

Published:January 07, 2008DOI:https://doi.org/10.1016/j.jclinepi.2007.08.002
Interim monitoring of efficacy data is important and appropriate
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      In this issue, Bassler et al. [
      • Bassler D.
      • Montori V.M.
      • Briel M.
      • Glasziou P.
      • Guyatt G.
      Early stopping of randomised clinical trials for overt efficacy is problematic.
      J Clin Epidemiol. 2008; 61: 241-246
      ] provide a good review of some of the dangers of stopping clinical trials early for benefit, including a likely overestimation of the true treatment effect.
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      References

        • Bassler D.
        • Montori V.M.
        • Briel M.
        • Glasziou P.
        • Guyatt G.
        Early stopping of randomised clinical trials for overt efficacy is problematic.
        J Clin Epidemiol. 2008; 61: 241-246
        View in Article
        • Montori V.M.
        • Devereaux P.J.
        • Adhikari N.K.
        • Burns K.E.
        • Eggert C.H.
        • Briel M.
        • et al.
        Randomized trials stopped early for benefit: a systematic review.
        J Am Med Assoc. 2005; 294: 2203-2209
        View in Article

      Article info

      Publication history

      Published online: January 07, 2008
      Accepted: August 3, 2007

      Identification

      DOI: https://doi.org/10.1016/j.jclinepi.2007.08.002

      Copyright

      © 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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