In this issue, Bassler et al. [
[1]
] provide a good review of some of the dangers of stopping clinical trials early for
benefit, including a likely overestimation of the true treatment effect.To read this article in full you will need to make a payment
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References
- Early stopping of randomised clinical trials for overt efficacy is problematic.J Clin Epidemiol. 2008; 61: 241-246
- Randomized trials stopped early for benefit: a systematic review.J Am Med Assoc. 2005; 294: 2203-2209
Article info
Publication history
Published online: January 07, 2008
Accepted:
August 3,
2007
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.