Interim monitoring of efficacy data is important and appropriate

Matthew R. Sydes; Mahesh K.B. Parmar

doi:10.1016/j.jclinepi.2007.08.002

Invited Commentary| Volume 61, ISSUE 3, P203-204, March 2008

Interim monitoring of efficacy data is important and appropriate

Matthew R. Sydes
Matthew R. Sydes
Correspondence
Corresponding author. Tel.: +44 (0) 207 670 4798; fax: +44 (0) 207 670 4865.
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MRC Clinical Trials Unit, Cancer Group, 222 Euston Road, London NWI 2DA, UK
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Mahesh K.B. Parmar
Mahesh K.B. Parmar
Affiliations
MRC Clinical Trials Unit, Cancer Group, 222 Euston Road, London NWI 2DA, UK
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Published:January 07, 2008DOI:https://doi.org/10.1016/j.jclinepi.2007.08.002

In this issue, Bassler et al. [

[1]

Bassler D.
Montori V.M.
Briel M.
Glasziou P.
Guyatt G.

Early stopping of randomised clinical trials for overt efficacy is problematic.

] provide a good review of some of the dangers of stopping clinical trials early for benefit, including a likely overestimation of the true treatment effect.

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References

- Bassler D.
- Montori V.M.
- Briel M.
- Glasziou P.
- Guyatt G.
Early stopping of randomised clinical trials for overt efficacy is problematic.
J Clin Epidemiol. 2008; 61: 241-246
View in Article
- Montori V.M.
- Devereaux P.J.
- Adhikari N.K.
- Burns K.E.
- Eggert C.H.
- Briel M.
- et al.
Randomized trials stopped early for benefit: a systematic review.
J Am Med Assoc. 2005; 294: 2203-2209
View in Article

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Published online: January 07, 2008

Accepted: August 3, 2007

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DOI: https://doi.org/10.1016/j.jclinepi.2007.08.002

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Interim monitoring of efficacy data is important and appropriate

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