Abstract
Objective
To determine the validity of self-reported hepatitis B virus (HBV) and hepatitis C
virus (HCV) in HIV-infected injection drug users (IDUs) vs. nonIDUs.
Methods
A cross-sectional study was performed among HIV-infected IDUs and nonIDUs in the Penn
Center for AIDS Research (CFAR) Database. Self-reported past HBV, HCV, and serostatus
were obtained from the CFAR Database.
Results
Among 970 subjects (798 nonIDUs; 172 IDUs), there was no difference in sensitivity
of self-reported HBV between nonIDUs (27% [95/346]; 95% CI, 23%–32%) and IDUs (26%
[31/117]; 95% CI, 19%–35%; P>0.5), but specificity was greater among nonIDUs (96% [360/374; 95% CI, 94%–98%] vs.
78% [28/36; 95% CI, 61%–90%]; P<0.001). Sensitivity of self-reported HCV was greater among IDUs (78% [101/130; 95%
CI, 70%–85%] vs. 62% [47/76; 95% CI, 50%–73%]; P=0.02), but there was no difference in specificity (97% [626/643]; 95% CI, 96%–98%
for nonIDUs vs. 93% [26/28]; 95% CI, 76%–99%] for IDUs; P=0.2).
Conclusions
The sensitivity of self-reported HBV and HCV compared to actual serostatus are not
sufficiently high enough to warrant their use to estimate the prevalence and incidence
of these infections.
Keywords
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References
- Hepatitis B in the human immunodeficiency virus-infected patient: epidemiology, natural history, and treatment.Semin Liver Dis. 2003; 23: 125-136
- Hepatitis C in the HIV-infected person.Ann Intern Med. 2003; 138: 197-207
- The prevalence of hepatitis C virus infection in the United States, 1988 through 1994.N Engl J Med. 1999; 341: 556-562
- Hepatitis C virus prevalence among patients infected with human immunodeficiency virus: a cross-sectional analysis of the US adult AIDS Clinical Trials Group.Clin Infect Dis. 2002; 34: 831-837
- Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group.Hepatology. 1999; 30: 1054-1058
- Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: a meta-analysis.Clin Infect Dis. 2001; 33: 562-569
- Interactions of the human immunodeficiency virus and the hepatotropic viruses.Semin Liver Dis. 1992; 12: 188-196
- Prevalence of chronic hepatitis B and incidence of acute hepatitis B infection in human immunodeficiency virus-infected subjects.J Infect Dis. 2003; 188: 571-577
- HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS).Lancet. 2002; 360: 1921-1926
- Validity of injecting drug users' self report of hepatitis A, B, and C.Clin Lab Sci. 2003; 16: 99-106
- Accuracy of perceptions of hepatitis B and C status: cross sectional investigation of opiate addicts in treatment.BMJ. 1999; 319: 290-291
- Hepatitis C disease among injection drug users: knowledge, perceived risk and willingness to receive treatment.Drug Alcohol Depend. 2001; 61: 211-215
- Poor validity of self-reported hepatitis B virus infection and vaccination status among young drug users.Clin Infect Dis. 2004; 38: 587-590
- Modern epidemiology.2nd edition. Lippincott Williams and Wilkins, Philadelphia1998
- The prevalence of hepatitis B and C in HIV-positive Greek patients: relationship to survival of deceased AIDS patients.J Infect. 2000; 40: 127-131
- Frequent occult hepatitis B virus infection in patients infected with human immunodeficiency virus type 1.Eur J Clin Microbiol Infect Dis. 2003; 22: 92-98
- Fundamentals of biostatistics.5th edition. Duxbury, Pacific Grove2000
Article info
Publication history
Published online: November 10, 2006
Accepted:
June 2,
2006
Identification
Copyright
© 2007 Elsevier Inc. Published by Elsevier Inc. All rights reserved.