Abstract
Objective
To determine the validity of self-reported hepatitis B virus (HBV) and hepatitis C
virus (HCV) in HIV-infected injection drug users (IDUs) vs. nonIDUs.
Methods
A cross-sectional study was performed among HIV-infected IDUs and nonIDUs in the Penn
Center for AIDS Research (CFAR) Database. Self-reported past HBV, HCV, and serostatus
were obtained from the CFAR Database.
Results
Among 970 subjects (798 nonIDUs; 172 IDUs), there was no difference in sensitivity
of self-reported HBV between nonIDUs (27% [95/346]; 95% CI, 23%–32%) and IDUs (26%
[31/117]; 95% CI, 19%–35%; P>0.5), but specificity was greater among nonIDUs (96% [360/374; 95% CI, 94%–98%] vs.
78% [28/36; 95% CI, 61%–90%]; P<0.001). Sensitivity of self-reported HCV was greater among IDUs (78% [101/130; 95%
CI, 70%–85%] vs. 62% [47/76; 95% CI, 50%–73%]; P=0.02), but there was no difference in specificity (97% [626/643]; 95% CI, 96%–98%
for nonIDUs vs. 93% [26/28]; 95% CI, 76%–99%] for IDUs; P=0.2).
Conclusions
The sensitivity of self-reported HBV and HCV compared to actual serostatus are not
sufficiently high enough to warrant their use to estimate the prevalence and incidence
of these infections.
Keywords
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Article info
Publication history
Published online: November 10, 2006
Accepted:
June 2,
2006
Identification
Copyright
© 2007 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
