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Original Article| Volume 60, ISSUE 3, P294-299, March 2007

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Self-reported hepatitis B and C virus infections had low sensitivity among HIV-infected patients

  • Vincent Lo Re III
    Correspondence
    Corresponding author. Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 711 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA. Tel.: 215-573-5964; fax: 215-349-5111.
    Affiliations
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
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  • Ian Frank
    Affiliations
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
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  • Robert Gross
    Affiliations
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
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  • Marie Synnestvedt
    Affiliations
    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
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  • A. Russell Localio
    Affiliations
    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
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  • Jay R. Kostman
    Affiliations
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
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  • Brian L. Strom
    Affiliations
    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
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Published:November 10, 2006DOI:https://doi.org/10.1016/j.jclinepi.2006.06.020

      Abstract

      Objective

      To determine the validity of self-reported hepatitis B virus (HBV) and hepatitis C virus (HCV) in HIV-infected injection drug users (IDUs) vs. nonIDUs.

      Methods

      A cross-sectional study was performed among HIV-infected IDUs and nonIDUs in the Penn Center for AIDS Research (CFAR) Database. Self-reported past HBV, HCV, and serostatus were obtained from the CFAR Database.

      Results

      Among 970 subjects (798 nonIDUs; 172 IDUs), there was no difference in sensitivity of self-reported HBV between nonIDUs (27% [95/346]; 95% CI, 23%–32%) and IDUs (26% [31/117]; 95% CI, 19%–35%; P>0.5), but specificity was greater among nonIDUs (96% [360/374; 95% CI, 94%–98%] vs. 78% [28/36; 95% CI, 61%–90%]; P<0.001). Sensitivity of self-reported HCV was greater among IDUs (78% [101/130; 95% CI, 70%–85%] vs. 62% [47/76; 95% CI, 50%–73%]; P=0.02), but there was no difference in specificity (97% [626/643]; 95% CI, 96%–98% for nonIDUs vs. 93% [26/28]; 95% CI, 76%–99%] for IDUs; P=0.2).

      Conclusions

      The sensitivity of self-reported HBV and HCV compared to actual serostatus are not sufficiently high enough to warrant their use to estimate the prevalence and incidence of these infections.

      Keywords

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