We read with great interest an article by Keijzer-Veen et al. [
[1]
] in which they propose a regression model to overcome the problem of adjustment for
current body weight in the fetal origins of adult disease hypothesis. Instead of adjusting
for current body weight, Keijzer-Veen et al. proposed that the unexplained residual
current body weight (CWres) should be adjusted for. The variable CWres comprises residuals of the simple regression model where current body weight is regressed
on birth weight; Keijzer-Veen et al. considered CWres to be the difference between attained (current body weight) and predicted (by birth
weight) adult body weight. They recognized that adjustment for current body weight
might not be justified because current body weight falls on the pathway between birth
weight and disease outcome, and they therefore prefer their alternative approach because
it estimates the effects of birth weight and the effect of additional weight gain
in a single model.To read this article in full you will need to make a payment
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References
- A regression model with unexplained residuals was preferred in the analysis of the fetal origins of adult diseases hypothesis.J Clin Epidemiol. 2005; 58: 1320-1324
- Why evidence of fetal origins of adult diseases can be statistical artifact: the reversal paradox examined for hypertension.Am J Epidemiol. 2005; 161: 27-32
- Fetal origins of adult disease-the hypothesis revisited.BMJ. 1999; 319: 245-249
- The geometry of multivariate statistic.Lawrence Erlbaum Associates, Hillsdale, NJ1995
- Revisiting four-model principle in fetal origins hypothesis.Pediatr Res. 2005; 58 ([abstract]): 1013
Article info
Publication history
Published online: October 25, 2006
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© 2007 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
