Abstract
Background and objective
The aim of this study is to evaluate the relationship between the interval from first
symptom to diagnosis (SDI) and the degree of invasion and survival in lung cancer.
Methods
Three hundred seventy-eight patients with lung cancer were included. SDI was defined
as the time calculated from the cytohistologic confirmation of the diagnosis of cancer
and the first symptoms noted by the patient and attributed to cancer by the physician.
The degree of invasion was determined by TNM classification.
Results
The median SDI was 2.1 months, and did not correlate with stage. Survival decreased
progressively according to TNM classification. Adjusting for age, sex, SDI and TNM,
survival was influenced by age (RR = 1.02) and by staging [Stage (Ib) RR = 1.3; stage (IIIa) RR = 2.6; stage (IIIb) RR = 4.06; stage (IV) RR = 7.5]. SDI was not found to affect survival (RR = 1.01; 95% CI: 0.94–1.08). In the small cell group, SDI also failed to modify survival.
Conclusions
The results of this study indicate that SDI has no effect on the stage or survival
of patients with lung cancer.
Keywords
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Article info
Publication history
Accepted:
February 12,
2003
Identification
Copyright
© 2003 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
