Abstract
Background and Objective: The MDP75 (Minimal Difference Perceived 75% of the time) is the difference in the
global score from a scale or a questionnaire which, 75% of the time, leads to the
higher score being spontaneously attributed by patients or clinicians to the most
severe situation. This may be considered as a “minimal clinically perceptible difference”
because the proportion of “consistent” choices only exceeds the proportion that could
be observed “by chance” by 50%.
Methods: The MDP75 can be estimated through a comparison of two groups of items (group A and
group B) randomly selected from the instrument, using a sample of subjects. A logistic
regression is then used that relates the choice of A or B to the difference: score(A)
– score(B).
Results: Data were collected on a depression scale, the HDRS. Three clinicians classified
300 pairs of situations. The MDP75 obtained was 2.7, with a 95% confidence interval
of [1.9, 4.1].
Conclusion: It can be noted that this value is consistent with expert opinion (3 or 4). Nevertheless,
in view of the small number of clinicians involved in the data collection phase, further
studies are required to confirm this result.
Keywords
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© 2003 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
