Abstract
Prior research has conflicted on whether increased levels of plasma fibrinolytic factors
may identify patients at risk of venous thromboembolism (VTE). We therefore performed
a nested case–control study of VTE within two prospective population-based studies.
In 308 participants who developed VTE and 640 controls, we measured PAI-1 antigen,
tPA/PAI-1 complex, plasmin-α2-antiplasmin (PAP), and the PAI-1 −675 4G/5G promoter polymorphism on pre-event blood
samples. There was no overall association between any of these fibrinolytic variables
and VTE, after adjustment for age or for multiple VTE risk factors. There was weak
evidence for an interaction of PAP with elevated factor VIIIc and elevated D-dimer
in augmenting VTE risk. We conclude that, for the most part, these fibrinolytic markers
do not identify healthy subjects at risk for VTE.
Keywords
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Article info
Publication history
Accepted:
January 30,
2003
Received in revised form:
November 11,
2002
Received:
May 31,
2002
Identification
Copyright
© 2003 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
