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Letter to the editor| Volume 56, ISSUE 3, P290-291, March 2003

Apportionment of disease in individuals

      There is a growing need, especially in legal and policy arenas, for methods to apportion disease in an individual to the specific “causes” of the disease. In a recent issue, McElduff and colleagues [
      • McElduff P.
      • Attia J.
      • Ewald B.
      • Cockburn J.
      • Heller R.
      Estimating the contribution of individual risk factors to disease in a person with more than one risk factor.
      ] propose a model that they purport could be used in litigation to apportion disease (and ultimately damages) in individuals to multiple “causes” of interest. Their approach, similar to previously published methods [
      • Chase G.R.
      • Kotin P.
      • Crump K.
      • Mitchell R.S.
      Evaluation for compensation of asbestos-exposed individuals: II. Apportionment of risk for lung cancer and mesothelioma.
      ,
      • Grimson R.C.
      Apportionment of risk among environmental exposures, application to asbestos exposure and cigarette smoking.
      ], basically apportions disease to a selected set of risk factors based on studies of external populations. Thus, McElduff et al. [
      • McElduff P.
      • Attia J.
      • Ewald B.
      • Cockburn J.
      • Heller R.
      Estimating the contribution of individual risk factors to disease in a person with more than one risk factor.
      ] and their predecessors apply population-based attributable risk measures to apportion disease in individuals. Others have commented on common interpretational pitfalls of attributable risk measures [
      • Greenland S.
      Relation of probability of causation to relative risk and doubling dose: a methodological error that has become a social problem.
      ].
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      References

        • McElduff P.
        • Attia J.
        • Ewald B.
        • Cockburn J.
        • Heller R.
        Estimating the contribution of individual risk factors to disease in a person with more than one risk factor.
        J Clin Epidemiol. 2002; 55: 588-592
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        • Mitchell R.S.
        Evaluation for compensation of asbestos-exposed individuals:.
        J Occup Med. 1985; 27: 189-198
        • Grimson R.C.
        Apportionment of risk among environmental exposures, application to asbestos exposure and cigarette smoking.
        J Occup Med. 1987; 29: 253-255
        • Greenland S.
        Relation of probability of causation to relative risk and doubling dose: a methodological error that has become a social problem.
        Am J Public Health. 1999; 89: 1166-1169
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        The privatization of risk.
        Am J Public Health. 2001; 91: 365-368
        • Rothman K.J.
        Modern epidemiology. Little, Brown and Company, Boston1986
        • Rothman K.J.
        • Greenland S.
        Modern epidemiology. Lippincott Raven, Philadelphia1998 (p. 11)