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Abstract
It has been hypothesized that hyperestrogenemia may underlie myocardial infarction.
As a test of this hypothesis, the serum estradiol and testosterone levels were estimated
in samples collected prospectively from 96 male patients aged 52–74 years [mean age
60.8 ± 6.3 (SD)] who had had a myocardial infarction and from 96 matched control subjects
in the Honolulu Heart Program. Established risk factors for myocardial infarction
were measured prospectively. No significant difference between patients and control
subjects in mean estradiol or testosterone level was observed. The only established
risk factor that was significantly different was blood pressure, which was higher
in the patients. Thus, the data did not confirm the hypothesis. However, two major
pitfalls for prospective studies of estradiol in myocardial infarction, which might
have affected the validity of the results, were observed, namely, deterioration of
estradiol values with prolonged storage (8.5–12 years in this study) and intervention.
The value of this study, therefore, may he in pointing out difficulties in carrying
out prospective studies on sex hormones.
Keywords
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Article info
Publication history
Received:
June 29,
1988
Identification
Copyright
© 1988 Published by Elsevier Inc.
