An epidemiologic study of the relationships of peptic ulcer disease in 50–54 year old, urban males with physical, health and smoking factors

      This paper is only available as a PDF. To read, Please Download here.


      402 subjects randomly selected from the total population of all males between the ages of 50–54 yr in one Prague city district were chosen for a comprehensive epidemiologic survey.
      The collected data included information on history of peptic ulcer disease (PUD) and 65 independent parameters grouped in 4 categories; (a) cardiovascular variables (b) respiratory tract and smoking habits, (c) ‘stress’ factors, and (d) physical and social status. Multiple regression analyses showed no associations between peptic ulcer and the variables in these four categories. When the population was analyzed by blood pressure quartiles significant positive correlations were noted for ECG signs of ventricular conduction defect, vital capacity, presence of bacteriuria, symptoms of headache, intermittent claudication, night dyspnea, nervousness, and history of hematuria. The possibility that subjects with high blood pressure and PUD have some unidentified factor in common is suggested.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Clinical Epidemiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


      1. Pfeiffer CJ Peptic Ulcer. J. B. Lippincott, Philadelphia and Toronto1971
        • Doll R
        • Avery JF
        Occupational Factors in the Aetiology of Gastric and Duodenal Ulcers.
        (London)in: Medical Research Council Special Report Series No. 276. His Majesty's Stationery Office, 1951
        • Watkinson G
        The incidence of chronic peptic ulcer found at necropsy.
        Gut. 1960; 1: 14-30
        • Levij IS
        • De La Fuente AA
        A post-mortem study of gastric and duodenal peptic lesions.
        Gut. 1963; 4: 349-359
        • Roessle R
        Das runde Geschwuer des Magens und des Zwoelfingerdarm als ‘Zweite Krankheit’.
        Mitt Grenzgebieten Med Chir. 1912–1913; 25: 766-796
        • Walsh BJ
        • Bland EF
        • Taquini AC
        • et al.
        The association of gall bladder disease and of peptic ulcer with coronary disease; a post-mortem study.
        Am Heart J. 1941; 21: 689-698
        • Morrison LM
        • Gonzalez WF
        The relationship of chronic peptic ulcer to coronary thrombosis.
        Am J Med Sci. 1952; 224: 314-317
        • Klein MM
        • Walsh EL
        Relation between cardiac failure and gastric ulcer in the older age group.
        Radiol. 1958; 70: 672-683
        • Wornas CG
        • Imber I
        Cardiac infarction with gastrointestinal manifestations.
        Vas Dis. 1964; 1: 162-171
        • McNamara JJ
        • Austen WG
        Gastrointestinal bleeding occurring in patients with acquired valvular heart disease.
        Arch Surg. 1968; 97: 538-540
        • Pfeiffer CJ
        • Sethbhakdi S
        Vascular impairment—An Etiologic factor in peptic ulcer? Part VI.
        in: Peptic Ulcer. Lippincott, Philadelphia1971
        • Weber JM
        • Gregg LA
        The coincidence of benign gastric ulcer and chronic pulmonary disease.
        Ann Int Med. 1955; 42: 1026-1030
        • Latts EM
        • Cummins JF
        • Zieve L
        Peptic ulcer and pulmonary emphysema.
        Arch Int Med. 1956; 97: 576-584
        • Silen W
        • Brown WH
        • Eiseman B
        Peptic ulcer and pulmonary emphysema.
        Arch Surg. 1959; 78: 897-903
        • Glick DL
        • Kern Jr, F
        Peptic ulcer and chronic obstructive bronchopulmonary disease.
        Gastroenterol. 1964; 47: 153-160
        • Monson RR
        Duodenal Ulcer as a second disease.
        Gastroenterol. 1970; 59: 712-716
        • Barnett CW
        Tobacco smoking as a factor in the production of peptic ulcer and gastric neurosis.
        Boston Med Surg J. 1927; 197: 457-459
        • Doll R
        • Avery Jones F
        • Pygott F
        Effect of smoking on the production and maintenance of gastric and duodenal ulcers.
        Lancet. 1958; 1: 657-662
        • Monson RR
        Cigarette smoking and body form in peptic ulcer.
        Gastroenterol. 1970; 58: 337-344
      2. Fodor J, Geizerova H, Hejl Z: Epidemiology of cardiovascular diseases in a random sample of a male, urban population at 50–54 yr of age (in preparation)

        • Nie NH
        • Bent DH
        • Hull CH
        Statistical Package for the Social Sciences.
        in: McGraw Hill, New York1970: 174-195
        • Tomenius J
        The incidence of peptic ulcer in Stockholm 1938–1952.
        Acta med Scand. 1955; 42: 391-411
        • Morris JN
        • Titmuss RM
        Epidemiology of peptic ulcer—vital statistics.
        Lancet. 1944; 2: 841-845
        • Feigenbaum J
        • Howat D
        The relation between physical constitution and the incidence of disease.
        J Clin Invest. 1934; 13: 121-127
        • Robinson SC
        • Brucer M
        The body build of the male ulcer patient.
        Am J Digest Dis. 1940; 7: 365-370
        • Wretmark G
        The peptic ulcer individual: a study in heredity, physique, and personality.
        Acta psychiat neurol scand Suppl. 1953; 84
        • Damon A
        • Polednak AP
        Constitution, genetics and body form in peptic ulcer: A review.
        J Chron Dis. 1967; 20: 787-802
        • Alexander F
        In general principles objectives, and preliminary results.
        in: The influence of psychologic factors upon gastrointestinal disturbances; A symposium. Psychoanal Quart. 3. 1934: 501-539
        • Sullivan AJ
        • McKell TE
        Personality in Peptic Ulcer.
        in: Charles C. Thomas, Springfield1950
        • Brinton W
        On the Pathology, Symptoms and Treatment of Ulcer of the Stomach.
        in: John Churchill, London1857
        • Hamilton M
        The personality of dyspeptics with special reference to gastric and duodenal ulcer.
        Brit Med J. 1950; 23: 182-198
        • Sultz HA
        • Schlesinger ER
        • Feldman JG
        • et al.
        The epidemiology of peptic ulcer in childhood.
        Am J Pub Hlth. 1970; 60: 492-498
        • Monson RR
        Familial factors in peptic ulcer—II. Family structure in duodenal ulcer.
        Am J Epidemiol. 1970; 91: 460-466
        • Susser M
        • Stein Z
        Civilization and peptic ulcer.
        Lancet. 1962; i: 115-119