Hashimoto's disease

An epidemiological critique
  • Alfonse T. Masi
    Correspondence
    Requests for reprints should be sent to Dr. Masi, Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205.
    Footnotes
    Affiliations
    The Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md. U.S.A.

    The Departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore, Md. U.S.A.
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  • William H. Hartmann
    Footnotes
    Affiliations
    The Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md. U.S.A.

    The Departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore, Md. U.S.A.
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  • Lawrence E. Shulman
    Footnotes
    Affiliations
    The Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md. U.S.A.

    The Departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore, Md. U.S.A.
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  • Author Footnotes
    ∗ Assistant Professor of Epidemiology and Instructor in Medicine, The Johns Hopkins University School of Hygiene and Public Health, Baltimore.
    † Assistant Professor of Pathology, The Johns Hopkins University School of Medicine, Baltimore.
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      References

        • Hashimoto H.
        Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma Lymphomatosa).
        Arch. klin. Chir. 1912; 97: 219
        • Rose N.R.
        • Witebsky E.
        Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts.
        J. Immunol. 1956; 76: 41
        • Witebsky E.
        • Rose N.R.
        Studies on organ specificity. IV. Production of rabbit thyroid antibodies in the rabbit.
        J. Immunol. 1956; 76: 408
        • Roitt I.M.
        • Doniach D.
        • Campbell P.N.
        • Hudson R.V.
        Auto-antibodies in Hashimoto's disease (lymphadenoid goitre).
        Lancet. 1956; 2: 820
        • Pickering G.W.
        Opportunity and universities.
        Lancet. 1952; 2: 895
        • Levitt T.
        The Thyroid: A Physiological, Pathological, Clinical and Surgical Study.
        Livingstone, Edinburgh and London1954 (Williams & Wilkins, Baltimore)
        • Hazard J.B.
        Thyroiditis: a review.
        Amer. J. clin. Path. 1955; 25: 289
        • Means J.H.
        • De Groot L.J.
        • Stanbury J.B.
        The Thyroid and Its Diseases.
        3rd edit. McGraw-Hill, New York1963
        • Riedel B.M.C.L.
        Die Chronische, zur Bildung eisenharten Tumoren führende Entzündung der Schilddrüse.
        Verh. dtsch. Ges. Chir. 1896; 25: 101
        • Riedel B.M.C.L.
        Verstellung eines Kranken mit chronischer Strumitis.
        Verh. dtsch. Ges. Chir. 1897; 26: 127
        • Riedel B.M.C.L.
        Uber Verlauf and Ausgang den Strumatis chronica.
        Münch. med. Wschr. 1910; 57: 1946
        • Graham A.
        Riedel's struma in contrast to struma lymphomatosa (Hashimoto).
        West. J. Surg. 1931; 39: 681
        • Danowski T.S.
        Thyroiditis.
        in: Clinical Endocrinology. 2nd edit. Thyroid. Vol. II. Williams & Wilkins, Baltimore1962: 429
        • Joll C.A.
        The pathology, diagnosis and treatment of Hashimoto's disease (struma lymphomatosa).
        Brit. J. Surg. 1939; 27: 351
        • Williamson G.S.
        • Pearse I.H.
        The pathological classification of goitre.
        J. Path. Bact. 1925; 28: 361
        • Vaux D.M.
        Lymphadenoid goitre: a study of 38 cases.
        J. Path. Bact. 1938; 46: 441
        • Vickery A.L.
        • Hamlin E.
        Struma lymphomatosa (Hashimoto's thyroiditis) observations on repeated biopsies in 16 patients.
        New Engl. J. Med. 1961; 264: 226
        • Paine J.R.
        • Terplan K.
        • Rose N.R.
        • Witebsky E.
        • Eagan R.W.
        A clinical study of chronic non-infectious thyroiditis and auto-immunization.
        Surgery. 1957; 42: 799
        • Eason J.
        The correlations of Graves' disease and thyroiditis.
        Edinb. Med. J. 1928; 35: 169
        • Graham A.
        • McCullagh E.P.
        Atrophy and fibrosis associated with lymphoid tissue in the thyroid.
        Arch. Surg. 1931; 22: 548
        • Buchanan W.W.
        • Alexander W.D.
        • Crooks J.
        • Koutras D.A.
        • Wayne E.J.
        • Anderson J.R.
        • Goudie R.E.
        Association of thyrotoxicosis and auto-immune thyroiditis.
        Brit. med. J. 1961; 1: 843
        • Buchanan W.W.
        • Koutras D.A.
        • Crooks J.
        • Alexander W.D.
        • Brass W.
        • Anderson J.R.
        • Goudie R.B.
        • Gray K.G.
        The clinical significance of the complement fixation test in thyrotoxicosis.
        J. Endocrin. 1962; 24: 115
        • Levitt T.
        The status of lymphadenoid goitre, Hashimoto's and Riedel's diseases.
        Ann. roy. Coll. Surg. 1952; 10: 369
        • Skillern P.G.
        • Crile G.
        • McCullagh E.P.
        • Hazard J.B.
        • Lewis L.A.
        • Brown H.
        Struma lymphomatosa: primary thyroid failure with compensatory thyroid enlargement.
        J. clin. Endocr. 1956; 16: 35
        • McConahey W.M.
        • Keating F.R.
        • Beahrs O.H.
        • Woolner L.B.
        On the increasing occurrence of Hashimoto's thyroiditis.
        J. clin. Endrocr. 1962; 22: 542
        • Beierwaltes W.H.
        Thyroiditis.
        Feb. 4, 1964 (Unpublished report presented at the New York Academy of Sciences, Conference on Autoimmunity, New York)
        • Spjut H.J.
        • Warren W.D.
        • Ackerman L.V.
        Clinical-pathologic study of 76 cases of recurrent Graves' disease, toxic (non-exophthalmic) goiter, and nontoxic goiter: does a relation exist between thyroid hyperplasia and struma lymphomatosa?.
        Amer. J. clin. Path. 1957; 27: 367
        • Stein A.A.
        A clinicopathologic review of 80 cases of struma lympomatosa.
        Surg. Gynec. Obstet. 1959; 109: 544
        • Woolner L.B.
        • McConahey W.M.
        • Beahrs O.H.
        Struma lymphomatosa (Hashimoto's thyroiditis) and related thyroidal disorders.
        J. clin. Endocr. 1959; 19: 53
        • Papazolu A.
        Contributions à l'étude de la pathogénie de la maladie de Basedow.
        C. R. Soc. Biol., Paris. 1911; 71: 671
        • Trotter W.R.
        • Belyavin G.
        • Wadhams A.
        Precipitating and complement-fixing antibodies in Hashimoto's disease.
        in: 2nd edit. Proc. roy. Soc. Med.50. 1957: 961
        • Whitesell Jr., F.B.
        • Black B.M.
        A statistical study of the clinical significance of lymphocytic and fibrocytic replacements in the hyperplastic thyroid gland.
        J. clin. endocrinol. 1949; 9: 1202
        • de Quervain F.
        Die akute, nicht eiterige thyreoiditis und die beteiligung der Schilddrüse an akuten intoxikationen und infektionen überhaupt.
        mitt a.d. Grenzgeb. d. med. v. chir. Suppl. 1904; 2: 1-165
        • de Quervain F.
        • Giordanengo G.
        Die akute und subakute nichteitrige Thyreoiditis.
        Mitt. Grenzgeb. Med. Chir. 1936; 44: 538
        • Eylan E.
        • Zmucky R.
        • Sheba C.
        Mumps virus and subacute thyroiditis: evidence of a causal association.
        Lancet. 1957; 1: 1062
        • Doniach D.
        • Hudson R.V.
        • Roitt I.M.
        Human auto-immune thyroiditis: clinical studies.
        Brit. med. J. 1960; 1: 365
        • Woolner L.B.
        • McConahey W.M.
        • Beahrs O.H.
        Granulomatous thyroiditis.
        J. clin. Endocr. 1957; 17: 1202
        • Bergen Jr., S.S.
        Acute nonsuppurative thyroiditis: a report of twelve cases and a review of the literature.
        Arch. intern. Med. 1958; 102: 747
        • Steinberg F.U.
        Subacute granulomatous thyroiditis: a review.
        Ann. intern. Med. 1960; 52: 1014
        • Friedman N.B.
        Cellular involution in the thyroid gland.
        J. clin. Endocr. 1949; 9: 874
        • Lindsay S.
        • Dailey M.E.
        • Friedlander J.
        • Yee G.
        • Soley M.H.
        Chronic thyroiditis: a clinical and pathological study of 354 patients.
        J. clin. Endocr. 1952; 12: 1578
        • Schmidt M.B.
        Eine biglandulare Erkrankung (Nebennieren und Schilddrüse) bei morbus Addisonii.
        Verh. dtsch. Ges. Path. 1926; 21: 212
        • Crile Jr., G.
        Treatment of diseases of thyroid gland.
        Ann. roy. Coll. Surg. 1954; 14: 158
        • Sommers S.C.
        • Meissner W.A.
        Basement membrane changes in chronic thyroiditis and other thyroid diseases.
        Amer. J. clin. Path. 1954; 24: 434
        • Hall R.
        • Owen S.G.
        • Smart G.A.
        Evidence for genetic predisposition to formation of thyroid autoantibodies.
        Lancet. 1960; 2: 187
      1. Shaw, A. F. B. and Smith, R. P.: Riedel's chronic thyroiditis: With a report of six cases and a contribution to the pathology, Brit. J. Surg. 13, 93, 125.

        • El Kabir D.J.
        • Doniach D.
        • Turner-Warwick R.
        Serum content of thyrotrophic hormone in human thyroiditis: low TSH levels with high radioiodine uptake in mild autoimmune thyroiditis.
        J. clin. Endocr. 1963; 23: 510
        • Smart G.A.
        • Owen S.G.
        Thyroiditis and hypothyroidism.
        J. chron. Dis. 1961; 14: 537
        • Douglass R.C.
        • Jacobson S.D.
        Pathologic changes in adult myxedemia: A survey of 10 necropsies.
        J. clin. Endocrinol. 1957; 17: 1354
        • Stuart A.E.
        • Allan W.S.A.
        The significance of basement membrane changes in thyroid disease.
        Lancet. 1958; 2: 1204
        • Waksman B.H.
        Auto-immunization and the lesions of auto-immunity.
        Medicine. 1962; 41: 93
        • Hektoen L.
        • Schulhof K.
        The precipitin reaction of thyroglobulin.
        in: 2nd edit. Proc. nat. Acad. Sci.11. 1925: 481
        • Witebsky E.
        • Rose N.R.
        • Terplan K.
        • Paine J.R.
        • Eagan R.W.
        Chronic thyroiditis and autoimmunization.
        J. Amer. med. Ass. 1957; 164: 1439
        • Rose N.R.
        • Kite J.H.
        • Doebbler T.K.
        Experimental autosensitization to thyroid.
        in: Presented at the New York Academy of Sciences, Conference on Autoimmunity, New York3 Feb. 1964
        • Thomas L.
        Circulating autoantibodies and human disease.
        New Engl. J. Med. 1964; 270: 1157
        • Hackett E.
        • Beech M.
        • Forbes I.J.
        Thyroglobulin antibodies in patients without clinical disease of the thyroid gland.
        Lancet. 1960; 2: 402
        • Hill O.W.
        Thyroglobulin antibodies in 1297 patients without thyroid disease.
        Brit. med. J. 1961; 1: 1793
        • Roitt I.M.
        • Doniach D.
        Human auto-immune thyroiditis. Serological studies.
        Lancet. 1958; 2: 1027
        • Parker R.H.
        • Beienvaltes W.H.
        Thyroid antibodies during pregnancy and in the newborn.
        J. clin Endocrinol. 1961; 21: 792
        • Felix-Davies D.
        • Waksman B.H.
        Passive transfer of experimental immune thyroiditis in the guinea pig.
        Arth. & Rheum. 1961; 4: 416
        • McMaster P.R.
        • Lerner E.M.
        • Exum E.D.
        The relationship of delayed hypersensitivity and circulating antibody to experimental allergic thyroiditis in inbred guinea pigs.
        J. exp. Med. 1961; 113: 611
        • Miescher P.
        • Gorstein F.
        • Benacerraf B.
        • Gell P.G.H.
        Studies on the pathogenesis of experimental immune thyroiditis.
        in: 2nd edit. Proc. Soc. exp. Biol., N. Y.107. 1961: 12
        • Buchanan W.W.
        • Anderson J.R.
        • Goudie R.B.
        • Gray K.G.
        A skin test in thyroid disease.
        Lancet. 1958; 2: 928
        • Blizzard R.M.
        • Chandler R.W.
        The history and present concepts of auto-immunization in thyroid disease.
        Pediatrics. 1960; 57: 399
        • Buchanan W.W.
        Autoimmune Thyroiditis, Disease-a-Month.
        Yearbook Medical Publishers, Inc, Chicago1962
        • Doniach D.
        • Roitt I.M.
        Auto-antibodies in disease.
        Ann. Rev. Med. 1962; 13: 213
        • Hall R.
        • Saxena K.M.
        • Owen S.G.
        A study of the parents of patients with Hashimoto's disease.
        Lancet. 1962; 2: 1291
        • Irvine W.J.
        • MacGregor A.G.
        • Stuart A.E.
        • Hall G.H.
        Hashimoto's disease in uniovular twins.
        Lancet. 1961; 2: 850
        • Zaino E.C.
        • Guerra W.
        Hashimoto's disease (struma lymphomatosa) in identical twins.
        Arch. intern. Med. 1964; 113: 70
        • Hung W.
        • Winship T.
        Struma lymphomatosa in mother and daughter with serologic and histologic evidence.
        J. clin. Endocr. 1963; 23: 465
        • Masi A.T.
        • Sartwell P.E.
        • Shulman L.E.
        The use of record linkage to determine familial occurrence of disease from hospital records.
        Publ. Hlth Rep. Wash. 1964; 79 (Abstract in) (To be published in Amer. J. publ. Hlth.): 208
        • Craig P.E.
        • Spann J.L.
        • Lowbeer L.
        Hashimoto's disease (struma lymphomatosa), a familial incidence of three cases.
        Amer. J. Surg. 1952; 84: 286
        • Dunning E.J.
        Struma lymphomatosa: report of 3 cases in one family.
        J. clin. Endocr. 1959; 19: 1121
        • De Groot L.J.
        • Hall R.
        • McDermott W.V.
        • Davis A.M.
        Hashimoto's thyroiditis—a genetically conditioned disease.
        New Engl. J. Med. 1962; 267: 267
        • Goldberg M.
        Incidence of hypothyroidism in more than one member of a family.
        Amer. J. med. Sci. 1960; 239: 562
        • Hall R.
        Immunologic aspects of thyroid function.
        New Engl. J. Med. 1962; 266: 1204
        • Volpe R.
        • Ezrin C.
        • MacAllister W.J.
        • Steiner J.W.
        Genetic factors in Hashimoto's struma.
        J. Canad. med. Ass. 1963; 88: 915
        • Haenszel W.
        Some problems in the estimation of familial risks of disease.
        J. nat. Cancer Inst. 1959; 23: 487
        • Lee J.G.
        Chronic nonspecific thyroiditis.
        Arch. Surg. 1935; 31: 982
        • Fowler E.F.
        The changing incidence and treatment of thyroid disease.
        Arch. Surg. 1960; 81: 733
        • Marshall S.F.
        • Meissner W.A.
        • Smith D.C.
        Chronic thyroiditis.
        New Engl.J.Med. 1948; 238: 758
        • Statland H.
        • Wasserman M.M.
        • Vickery A.L.
        Struma lymphomatosa (Hashimoto's struma).
        Arch. intern. Med. 1951; 88: 659
        • Hetz H.H.
        • Kearns J.E.
        • Teloh H.
        Lymphadenoid goiter (struma lymphomatosa) Hashimoto's disease.
        Quart. Bull. Northw. Univ. med. Sch. 1959; 33: 226
        • Kisner W.H.
        • Reganis J.
        • Haughton D.
        Thyroiditis.
        New Orleans med. surg. J. 1949; 102: 217
        • Chesky V.E.
        • Dreese W.C.
        • Hellwig C.A.
        Chronic thyroiditis.
        Surg. Gynec. Obstet. 1951; 93: 575
        • Hepinstall R.H.
        • Eastcott H.H.G.
        Hashimoto's disease, struma lymphomatosa.
        Brit. J. Surg. 1954; 41: 471
        • Harland W.A.
        • Franz V.K.
        Clinico-pathologic study of 261 surgical cases of so-called ‘thyroiditis’.
        J. clin. Endocr. 1956; 16: 1433
        • Macksood W.
        • Rapport R.L.
        • Hodges F.
        The increasing incidence of Hashimoto's disease.
        Arch. Surg. 1961; 83: 384
        • Hendrick J.W.
        Diagnosis and management of thyroiditis.
        J. Amer. med. Assoc. 1957; 164: 127-133
        • Priebe C.J.
        • Patterson H.A.
        Surgical aspects of chronic thyroiditis.
        Ann. Surg. 1959; 150: 965
        • Schlicke C.P.
        • Hill J.E.
        • Schultz G.F.
        Carcinoma in chronic thyroiditis.
        Surg. Gynec. Obstet. 1960; 111: 552
        • McClintock J.C.
        • Wright A.W.
        Riedel's struma and struma lymphomatosa (Hashimoto): comparative study.
        Ann. Surg. 1937; 106: 11
        • Pendergrast W.J.
        • Milmore B.K.
        • Marcus S.C.
        Thyroid cancer and thyrotoxicosis in the United States: their relation to endemic goiter.
        J. chron. Dis. 1961; 13: 22
        • Werner S.
        The Thyroid.
        2nd edit. Harper & Row, New York1962
        • Goudie R.B.
        • Anderson J.R.
        • Gray K.G.
        Complement-fixing antithyroid antibodies in hospital patients with asymptomatic thyroid lesions.
        J. Path. Bact. 1959; 77: 389
        • Williams E.D.
        • Doniach I.
        The post-mortem incidence of focal thyroiditis.
        J. Path. Bact. 1962; 83: 255
        • Mortensen J.D.
        • Woolner L.B.
        • Bennett W.A.
        Gross and microscopic findings in clinically normal thyroid glands.
        J. clin. Endocr. 1955; 15: 1270
      2. American Thyroid Association: Proceedings of Annual Meeting, New OrleansMay 10–12 1962
      3. (HIP) Health and Medical Care in New York City. 3rd edit. Health Insurance Plan of Greater New York—Committee for Special Research Project. Harvard University Press, Cambridge1957
        • Marshall S.F.
        • Meissner W.A.
        Struma lymphomatosa (Hashimoto's disease).
        Ann. Surg. 1955; 141: 737
        • Schade R.O.
        • Owen S.G.
        • Smart G.A.
        • Hall R.
        The relation of thyroid autoimmunity to round-cell infiltration of the thyroid gland.
        J. clin. Path. 1960; 13: 499
        • Collins S.D.
        • Lehmann J.L.
        • Trantham K.S.
        Surgical experience in selected areas of the United States.
        Publ. Hlth Monogr. No. 38. 1956;
        • Siegal M.
        • Lee S.L.
        • Widelock D.
        • Reilly E.B.
        • Wise G.J.
        • Zingale S.B.
        • Fuerst H.T.
        The epidemiology of systemic lupus erythematosus: preliminary results in New York City.
        J. chron. Dis. 1962; 15: 131
        • Luxton R.W.
        • Cooke R.T.
        Hashimoto's struma lymphomatosa. Diagnostic value of serum flocculation reactions.
        Lancet. 1956; 2: 105
        • Luxton R.W.
        Discussion on Hashimoto's disease, the clinical aspect.
        in: 3rd edit. Proc. roy. Soc. Med.50. 1957: 943
        • Luxton R.W.
        Paget's disease of bone associated with Hashimoto's struma lymphomatosa: a clue to the pathogenesis of Paget's disease?.
        Lancet. 1957; 1: 441
        • Anderson J.R.
        • Goudie R.B.
        • Timburry G.C.
        Autoantibodies in Addison's disease.
        Lancet. 1957; 1: 1123
        • Block K.J.
        • Wohl M.J.
        • Ship I.I.
        • Oglesby R.B.
        • Bunim J.J.
        Sjögren's syndrome. I. Serologic reactions in patients with Sjögren's syndrome with and without rheumatoid arthritis.
        Arth. & Rheum. 1960; 3: 287
        • White R.G.
        • Bass B.H.
        • Williams E.
        Lymphoid goitre and the syndrome of systemic lupus erythematosus.
        Lancet. 1961; 1: 368
        • Pettit M.D.
        • Landing B.H.
        • Guest E.M.
        Antithyroid antibody in juvenile diabetics (letter to the Editor).
        J. clin. Endocr. 1961; 21: 209
        • Buchanan W.W.
        • Crooks J.
        • Alexander W.D.
        • Koutras D.A.
        • Wayne E.F.
        • Gray K.G.
        Association of Hashimoto's thyroiditis and rheumatoid arthritis.
        Lancet. 1961; 1: 245
        • Markson J.L.
        • Moore J.M.
        Autoimmunity in pernicious anemia and iron deficiency anemia.
        Lancet. 1962; 2: 1240
        • Shulman L.E.
        • Harvey A.M.
        Hashimoto's thyroiditis in false-positive reactors to the tests for syphilis.
        Amer. J. Med. 1964; 36: 174
        • Williams E.D.
        • Engel E.
        • Forbes A.P.
        Thyroiditis and gonadal dysgenesis.
        New Engl. J. Med. 1964; 270: 805
        • Clark C.A.
        Genetics for the Clinician.
        C. Thomas, Springfield, Ill1962
      4. Masi, A. T., Hartmann, W. H., Hahn, B. H., Abbey, H. and Shulman, L. E.: Hashimoto's disease: A clinical-pathologic study with matched controls, Lancet, to be published

      5. Gilland, P., and Asper, S. P.: Personal communications, 1964.

        • Berkson J.
        Limitations of the application of four-fold table analysis to hospital data.
        Biometrics. 1946; 2: 47
        • Becker K.L.
        • Ferguson R.H.
        • McConahey W.H.
        The connective-tissue diseases and symptoms associated with Hashimoto's thyroiditis.
        New Engl. J. Med. 1963; 268: 277
        • Pierce C.S.
        Chance, Love and Logic.
        Harcourt-Brace, New York1923