A study of hypnotic drugs in patients with chronic diseases

Comparative efficacy of placebo; methyprylon (Noludar); meprobamate (Miltown, Equanil) pentobarbital; phenobarbital; secobarbital
  • Louis Lasagna
    From the Division of Clinical Pharmacology of the Department of Medicine, and the Department of Pharmacology and Experimental Therapeutics, Johns Hopkins University School of Medicine Baltimore, M.d. USA
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      • 1.
        1. A controlled clinical comparison has been made of placebo, pentobarbital, secobarbital, phenobarbital, methyprylon (Noludar), and meprobamate (Miltown Equanil), in 46 chronically ill patients.
      • 2.
        2. The effects of two dose levels of each drug on induction and duration of sleep, and over-all performance, as described by the patients, have been described and analyzed.
      • 3.
        3. Methyprylon (Noludar) and meprobamate (Miltown Equanil) have hypnotic properties, the former resembling pentobarbital and secobarbital, and the latter resembling phenobarbital, in performance.
      • 4.
        4. The most satisfactory therapeutic results were achieved with 0.2 Gm. of secobarbital and of pentobarbital; these drugs are recommended as standards against which new drugs should be compared.
      • 5.
        5. Unpleasant side effects were infrequent with all medications.
      • 6.
        6. Chronically ill patients with insomnia provide a useful population for the evaluation of hypnotic drugs.
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