- 1.1. A controlled clinical comparison has been made of placebo, pentobarbital, secobarbital, phenobarbital, methyprylon (Noludar), and meprobamate (Miltown Equanil), in 46 chronically ill patients.
- 2.2. The effects of two dose levels of each drug on induction and duration of sleep, and over-all performance, as described by the patients, have been described and analyzed.
- 3.3. Methyprylon (Noludar) and meprobamate (Miltown Equanil) have hypnotic properties, the former resembling pentobarbital and secobarbital, and the latter resembling phenobarbital, in performance.
- 4.4. The most satisfactory therapeutic results were achieved with 0.2 Gm. of secobarbital and of pentobarbital; these drugs are recommended as standards against which new drugs should be compared.
- 5.5. Unpleasant side effects were infrequent with all medications.
- 6.6. Chronically ill patients with insomnia provide a useful population for the evaluation of hypnotic drugs.
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☆This work was supported in part by a grant from the United States Public Health Service, National Institutes of Health, Number B-865, and in part by a grant from Eli Lilly and Company.
☆☆The methyprylon (Noludar) used in this study was generously supplied by Hoffmann-La Roche, Inc., through Dr. Leo Pirk.
★The Miltown used in this study was generously supplied by Wallace Laboratories, through Miss Margaret Gerber and Dr. F. M. Berger.