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A study of hypnotic drugs in patients with chronic diseases

Comparative efficacy of placebo; methyprylon (Noludar); meprobamate (Miltown, Equanil) pentobarbital; phenobarbital; secobarbital
  • Louis Lasagna
    Affiliations
    From the Division of Clinical Pharmacology of the Department of Medicine, and the Department of Pharmacology and Experimental Therapeutics, Johns Hopkins University School of Medicine Baltimore, M.d. USA
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      Abstract

      • 1.
        1. A controlled clinical comparison has been made of placebo, pentobarbital, secobarbital, phenobarbital, methyprylon (Noludar), and meprobamate (Miltown Equanil), in 46 chronically ill patients.
      • 2.
        2. The effects of two dose levels of each drug on induction and duration of sleep, and over-all performance, as described by the patients, have been described and analyzed.
      • 3.
        3. Methyprylon (Noludar) and meprobamate (Miltown Equanil) have hypnotic properties, the former resembling pentobarbital and secobarbital, and the latter resembling phenobarbital, in performance.
      • 4.
        4. The most satisfactory therapeutic results were achieved with 0.2 Gm. of secobarbital and of pentobarbital; these drugs are recommended as standards against which new drugs should be compared.
      • 5.
        5. Unpleasant side effects were infrequent with all medications.
      • 6.
        6. Chronically ill patients with insomnia provide a useful population for the evaluation of hypnotic drugs.
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