Journal of Clinical Epidemiology
Volume 52, Issue 12 , Pages 1187-1195 , December 1999

Effect of Hormone Replacement Therapy on the Validity of the Friedewald Equation in Postmenopausal Women: The Postmenopausal Estrogen/Progestins Interventions (PEPI) Trial

  • Claudine Legault

      Affiliations

    • Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC USA
    • Corresponding Author InformationAddress for correspondence: Claudine Legault, PhD, Dept. of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd., Winston Salem, NC 27157-1063.
    • ,
  • Marcia L Stefanick

      Affiliations

    • Stanford Center for Research in Disease Prevention, Palo Alto, CA USA
    • ,
  • Valery T Miller

      Affiliations

    • George Washington University, Washington, DC USA
    • ,
  • Santica M Marcovina

      Affiliations

    • Department of Medicine, University of Washington, Seattle, WA USA
    • ,
  • Helmut G Schrott

      Affiliations

    • Department of Preventive Medicine and Environmental Health, University of Iowa College of Medicine, Iowa City, IA USA

,Accepted 7 May 1999.

References 

  1. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  2. Niedbala RS, Schray KJ, Foery R, Clement G. Estimation of low-density lipoprotein by the Friedewald formula and by electrophoresis compared [letter]. Clin Chem. 1985;31:1762–1763
  3. Demacker PN, Hijmans AG, Brenninkmeijer BJ, et al.  Five methods for determining low-density lipoprotein cholesterol compared. Clin Chem. 1984;30:1797–1800
  4. Myers LH, Phillips NR, Havel RJ. Mathematical evaluation of methods for estimation of the concentration of the major lipid components of human serum lipoproteins. J Lab Clin Med. 1976;88:491–505
  5. Kuba K, Frantz ID. Validity of the Friedewald equation for the estimation of plasma low-density lipoprotein cholesterol (LDL-C) at various concentrations of triglycerides [abstract]. Clin Chem. 1987;33:896
  6. Wilson PW, Abbott RD, Garrison RJ, Castelli WP. Estimation of very-low-density lipoprotein cholesterol from data on triglyceride concentration in plasma. Clin Chem. 1981;27:2008–2010
  7. Rao A, Parker AH, El-Sheroni NA, Babelly MM. Calculation of low-density lipoprotein cholesterol with use of triglyceride/cholesterol ratios in lipoproteins compared with other calculation methods. Clin Chem. 1988;34:2532–2534
  8. Lippi U, Graziani MS, Manzato F, Schinella M. The Friedewald formula (Statistical acrobatics?). Clin Chem. 1986;32:909–910
  9. Warnick GR, Knopp RH, Fitzpatrick V, Branson L. Estimating low-density lipoprotein cholesterol by the Friedewald equation is adequate for classifying patients on the basis of nationally recommended cutpoints. Clin Chem. 1990;36:15–19
  10. DeLong DM, DeLong ER, Wood PD, Lippel K, Rifkind BM. A comparison of methods for the estimation of plasma low-and very-low-density lipoprotein cholesterol (The Lipid Research Clinics Prevalence Study). JAMA. 1986;256:2372–2377
  11. Friedlander Y, Kark JD, Eisenberg S, Stein Y. Calculation of LDL-cholesterol from total cholesterol, triglyceride and HDL-cholesterol (A comparison of methods in the Jerusalem Lipid Research Clinic Prevalence Study). Isr J Med Sci. 1982;18:1242–1252
  12. Winocour PH, Ishola M, Durrington PN. Validation of the Friedewald formula for the measurement of low density lipoprotein cholesterol in insulin-dependent diabetes mellitus. Clin Chim Acta. 1989;179:79–84
  13. Fujimoto WY. Friedewald's LDL-cholesterol estimation formula in a Japanese American population. Jpn Circ J. 1988;52:604–606
  14. Walsh BW, Schiff I, Rosner B, Greenberg L, Ravnikar V, Sacks FM. Effects of postmenopausal estrogen replacement on the concentration and metabolism of plasma lipoproteins. N Eng J Med. 1991;325:1196–1204
  15. Muesing RA, Miller VT, LaRosa JC, et al.  Effects of unopposed conjugated equine estrogen on lipoprotein composition and apolipoprotein-E distribution. J Clin Endocrinol Metab. 1992;75:1250–1254
  16. Miller VT, Muesing RA, LaRosa JC, Stoy DB, Fowler SE, Stillman RJ. Quantitative and qualitative changes in lipids, lipoproteins, apolipoprotein A-I and sex hormone-binding globulin due to two doses of conjugated equine estrogen with and without a progestin. Obstet Gynecol. 1994;83:173–179
  17. The writing group for the PEPI Trial . Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA. 1995;273:199–208
  18. Espeland MA, Bush TL, Mebane-Sims I, et al.  Rationale, design and conduct of the PEPI Trial. Controlled Clin Trials. 1995;16:3S–19S
  19. Wood PD, Kessler G, Lippel D, Stefanick ML, Wasilauskas CH, Wells HB. Physical and laboratory measurements in the PEPI Trial. Controlled Clin Trials. 1995;16:36S–53S
  20. Warnick GR. Enzymatic methods for quantification of lipoprotein lipids. Methods Enzymol. 1986;129:101–123
  21. Hainline A Jr, Karon J, Lippel K, Eds. Manual of Laboratory Operations: Lipid Research Clinics Program, Lipid and Lipoprotein Analysis, 2nd Ed. US Department of Health and Human Services, Public Health Service, National Institutes of Health (Updated 1983).
  22. Warnick GR, Benderson J, Albers JJ. Dextran sulfate-Mg2+ precipitation procedure for quantification of high-density lipoprotein cholesterol. Clin Chem. 1982;28:1279–1288
  23. Miller VT, Byington RL, Espeland MA, Langer R, Marcus R, Shumaker S, et al. Baseline characteristics of the PEPI participants. Controlled Clin Trials. 1995;16:54S–65S
  24. Wilson PWF, Zech LA, Gregg RE, Schaefer EJ, Hoeg JM, Spreder DL, et al. Estimation of VLDL Cholesterol in hyperlipidemia. Clin Chim Acta. 1985;151:285–291
  25. Rifai N, Warnick GR, McNamara JR, Belcher JD, Grinstead GF, Frantz ID. Measurement of low-density-lipoprotein cholesterol in serum (A status report). Clin Chem. 1992;38:150–160
  26. Wood PD, Haskel WL, Stern MP, et al.  Plasma lipoprotein distributions in male and female runners. Ann NY Acad Sci. 1977;301:748–752
  27. Bachorik PS, Ross JW. National Cholesterol Education Program recommendations for measurement of low-density lipoprotein cholesterol (Executive summary. The National Cholesterol Educating Program Working Group on Lipoprotein Measurement). Clin Chem. 1995;41(10):1414–1420

PII: S0895-4356(99)00107-9

Journal of Clinical Epidemiology
Volume 52, Issue 12 , Pages 1187-1195 , December 1999

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