Journal of Clinical Epidemiology
Volume 51, Issue 2 , Pages 159-164 , February 1998

HIV Vertical Transmission Rate Determinations Are Subject to Differing Definitions and Therefore Different Rates

  • Jane Pitt

      Affiliations

    • Department of Pediatrics, Columbia University College of Physicians And Surgeons, New York, New York USA
    • ,
  • Johanna Goldfarb

      Affiliations

    • Division of Pediatric and Adolescent Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio USA
    • ,
  • Mark Schluchter

      Affiliations

    • Department of Biostatistics and Epidemiology, The Cleveland Clinic Foundation, Cleveland, Ohio USA
    • Corresponding Author InformationMark D. Schluchter, Ph.D., Department of Biostatistics, Desk P-88, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, Cleveland OH 44195
    • ,
  • Andrea Kovacs

      Affiliations

    • Department of Pediatrics, Division of Pediatric Infectious Disease, LA County/USC Medical Center, Los Angeles, California USA
    • ,
  • Ellen Cooper

      Affiliations

    • Department of Pediatric Infectious Disease, Boston City Hospital, Boston, Massachusetts USA
    • ,
  • David Hodes

      Affiliations

    • Department of Pediatrics, Mount Sinai School of Medicine, New York, New York USA
    • ,
  • Kenneth McIntosh

      Affiliations

    • Division of Infectious Disease, The Children's Hospital, Boston, Massachusetts USA
    • ,
  • Hannah Peavy

      Affiliations

    • Division of Lung Diseases, National Heart, Lung and Blood Institute, Bethesda, Maryland USA
    • ,
  • William Shearer
    • ,
  • for the Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group

      Affiliations

    • Department of Allergy and Immunology, Texas Children's Hospital/Baylor College of Medicine, Houston, Texas USA

,Accepted 7 October 1997.

References 

  1. Andiman WA, Simpson BJ, Olson B. Rate of transmission of Human Immunodeficiency Virus Type 1 infection from mother to child and short-term outcome of neonatal infection. Am J Dis Child. 1990;144:758–766
  2. Blanche S, Rouzioux C, Moscato MLF. A retrospective study of infants born to women seropositive for Human Immunodeficiency Virus Type 1. N Engl J Med. 1989;320:1643–1648
  3. European Collaborative Study . Risk factors for mother-to-child transmission of HIV-1. Lancet. 1992;339:1007–1012
  4. Guay L, Ball P, Ndugwa C. Vertical transmission of HIV infection in Ugandan infants. Chicago, IL: ICAAC; 1991;258
  5. Italian Multicentre Study . Epidemiology, clinical features and prognostic factors of paediatric infection. Lancet. 1988;2:1043–1046
  6. Ryder RW, Nsa W, Hassig S. Perinatal transmission of the Human Immunodeficiency Virus Type 1 to infants of seropositive women in Zaire. N Engl J Med. 1989;320:1637–1642
  7. Conner EM, Sperling RS, Gelber R, et al.  Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N Engl J Med. 1994;331:1173–1180
  8. St. Louis E, Kamenga M, Brown C. Risk for perinatal HIV-1 Transmission according to maternal immunologic, virologic, and placental factors. JAMA. 1993;269:2853–2859
  9. Ruff AJ. Breastmilk, breastfeeding, and transmission of viruses to the neonate. Semin Perinatol. 1994;18(6):510–516
  10. Pitt J, McIntosh K, Goldfarb J, et al. %CD4 lymphocytes identifies HIV infected maternal risk for HIV transmission Washington, DC: First National Conference on Human Retroviruses and Related Infections; 1993.
  11. The P2C2 HIV Study Group . The Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study (Design and methods). J Clin Epidemiol. 1996;49:1285–1294
  12. Centers for Disease Control. 1994 Revised Classification System for Human Immunodeficiency Virus Infection in children less than thirteen years of age. MMWR 1994; 43(rr-12): 1–10.
  13. Hollinger F, Bremer J, Myers L, Gold J, McQuay L, The NIH/NIAID/DAIDS/ACTG Virology Laboratories . Standardization of Sensitive Human Immunodeficiency Virus Coculture Procedures and Establishment of a Multicenter Quality Assurance Program for the AIDS Clinical Trials Group. J Clin Microbiol. 1992;30(7):1787–1794
  14. Pitt J, Goldfarb J, Schluchter M, et al. Transmission rate determinations are subject to differing definitions and therefore different rates. In: Proceedings of the First National Conference on Human Retroviruses and Related Infections: Washington, DC; 1993: 175.
  15. McIntosh K, Pitt J, Brambilla D, et al.  Blood culture in the first 6 months of life for the diagnosis of vertically transmitted Human Immunodeficiency Virus infection. J Infect Dis. 1994;170:996–1000
  16. Dabis F, Msellati P, Dunn D, et al.  Estimating the rate of mother to child transmission of HIV. Report of a Workshop on Methodological Issues of Ghent (Belgium), 17–20 February 1992. AIDS. 1993;7:1139–1148
  17. Matheson PB, Weedon J, Cappelli M, et al.  Comparison of methods of estimating the mother-to-child transmission rate of Human Immunodeficiency Virus Type 1 (HIV-1). Am J Epidemiol. 1995;142(7):714–718
  18. Tsai WY, Goedert JJ, Orazem J, et al.  A nonparametric analysis of the transmission rate of human immunodeficiency virus from mother to infant. Biometrics. 1994;50(4):1015–1028
  19. Comeau AM, Pitt J, Hillyer G, et al.  Early detection of Human Immunodeficiency Virus on dried blood specimens (Sensitivity across serial specimens). J Pediatr. 1996;129:111–118

PII: S0895-4356(97)00239-4

Journal of Clinical Epidemiology
Volume 51, Issue 2 , Pages 159-164 , February 1998

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