Journal of Clinical Epidemiology
Volume 50, Issue 7 , Pages 845-849 , July 1997

Epidemiological Evidence for the Disruption of Ionized Calcium Homeostasis in the Elderly

  • John B Watson

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin USA
    • Corresponding Author InformationJohn B. Watson, Director of Molecular Diagnostics, Epicentre Technologies, 1202 Ann Street Madison WI 53713
    • ,
  • Kristine Lee

      Affiliations

    • Department of Ophthalmology, University of Wisconsin-Madison, Madison, Wisconsin USA
    • ,
  • Ronald Klein

      Affiliations

    • Department of Ophthalmology, University of Wisconsin-Madison, Madison, Wisconsin USA
    • ,
  • Barbara E.K Klein

      Affiliations

    • Department of Ophthalmology, University of Wisconsin-Madison, Madison, Wisconsin USA
    • ,
  • David D Koch

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin USA

,Accepted 3 February 1997.

References 

  1. Robertson WG, Marshall RW. Calcium measurements in serum and plasma—total and ionized. CRC Critical Reviews in Clinical Laboratory Sciences. 1979;11:271–304Review
  2. Spiegel AM. Pathophysiology of primary hyperparathyroidism. J Bone and Mineral Research. 1991;6(2):s15–s31Review
  3. Chernow B, Zaloga G, McFadden E, Clapper M, Kotler M, Barton M, et al. Hypocalcemia in critically ill patients. Crit Care Med. 1982;10:848–851
  4. Bertholf RL, Bertholf MF, Brown CM, Riley WJ. Ionized calcium buffering in the transfused anhepatic patient (Ab initio calculations of calcium ion concentrations). Annals Clinical and Laboratory Sci. 1992;22:40–50Review
  5. Bowers GN, Brassard C, Sena SF. Measurement of ionized calcium in serum with ion-selective electrodes (a mature technology that can meet the daily service needs). Clin Chem. 1986;32:1437–1447Review
  6. Morgan DB. The impact of ageing—present and future. Annals of Clinical Biochemistry. 1983;20:257–261
  7. Fraser CG, Cummings ST, Wilkinson SP, Neville RG, Knox JD, Ho O, et al. Biological variability of 26 clinical chemistry analytes in elderly people. Clin Chem. 1989;35:783–786
  8. Klein R, Klein BE, Linton KL, De Mets DL. The Beaver Dam Eye Study (Visual acuity). Ophthalmology. 1991;98:1310–1315
  9. Srivastava VK, Srivastava SK. Vitamin D3 and calcitonin-induced regulation of calcium and phosphate in rat lens—its significance in cataract formation. Annals of Ophthalmology. 1989;21:149–152
  10. Snedecor GW, Cochran WG. Statistical Methods. Ames, IA: Iowa State University Press; 1989;
  11. Ott L. An Introduction to Statistical Methods. Boston, MA: PWS-Kent Publishing Co; 1988;
  12. Fraser CG. Age-related changes in laboratory test results. Clinical implications. Drugs and Aging. 1993;3:246–257Review
  13. Palmer M, Jakobsson S, Akerstrom G, Ljunghall S. Prevalence of hypercalcaemia in a health survey (A 14-year follow-up study of serum calcium values). European J Clin Invest. 1988;18:39–46Review
  14. McLean FC, Hastings AB. A biological method for estimation of calcium ion concentration. J Biol Chem. 1934;107:337–350
  15. Ladenson JH, Lewis JW, Boyd JC. Failure of total calcium corrected for protein, albumin, and pH to correctly assess free calcium status. J Clin Endocrinol and Metabol. 1978;46:986–993
  16. Sorva A, Elfving S, Sievers G, Tilvis RS. Calcemic status of geriatric patients (A longitudinal study). Gerontology. 1992;38:87–91
  17. Sorva A, Elfving S, Pohja P, Tilvis RS. Assessment of calcaemic status in geriatric hospital patients (Serum ionized calcium versus albumin-adjusted total calcium). Scandinavian J Clin and Laboratory Invest. 1988;48:489–494
  18. Robertson WG, Marshall WG. Ionized calcium in body fluids. CRC Critical Reviews in Clinical Laboratory Sciences. 1981;13:85–125Review
  19. Drop LJ, Fuchs C, Stulz PM. Determination of blood ionized calcium in a large segment of the normal adult population. Clinica Chimica Acata. 1978;89:503–510
  20. Nevitt MC. Epidemiology of osteoporosis. Rheumatic Diseases Clin N Am. 1994;20:535–559Review
  21. Rubin CD. Osteoporosis (considerations in evaluating and managing the older patient). Texas Medicine. 1993;89:67–74Review
  22. Turek FW, Penev P, Zhang Y, van Reeth O, Zee P. Effects of age on the circadian system. Neuroscience and Biobehavioral Rev. 1995;19:53–58Review
  23. Schlienger JL, Pradignac A, Grunenberger F. Nutrition of the elderly (A challenge between facts and needs). Hormone Research. 1995;43:46–51Review
  24. Fleg JL, O'Connor F, Gerstenblith G, Becker LC, Clulow J, Schulman SP, et al. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol. 1995;78:890–900
  25. Thompson LV. Effects of age and training on skeletal muscle physiology and performance (see comments). Phys Therapy. 1994;74:71–81Review
  26. Mooradian AD. Mechanisms of age-related endocrine alterations. Part II. Drugs and Aging. 1993;3:131–146Review
  27. Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging. Endocrine Reviews. 1993;14:20–39Review
  28. Belanger A, Candas B, Dupont A, Cusan L, Diamond P, Gomez JL, et al. Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men. J Clin Endocrin and Metab. 1994;79:1086–1090
  29. Durlach J, Durlach V, Bac P, Rayssiguier Y, Bara M, Guiet-Bara A. Magnesium and ageing. II. Clinical data (Aetiological mechanisms and pathophysiological consequences of magnesium deficit in the elderly). Magnesium Res. 1993;6:379–394Review
  30. Bauer JH. Age-related changes in the renin-aldosterone system. Physiological effects and clinical implications. Drugs & Aging. 1993;3:238–245Review

PII: S0895-4356(97)00017-6

Journal of Clinical Epidemiology
Volume 50, Issue 7 , Pages 845-849 , July 1997

Article Tools

* Image Usage & Resolution