Journal of Clinical Epidemiology
Volume 49, Issue 12 , Pages 1447-1452, December 1996

Outbreak of multi-drug resistant Staphylococcus aureus: A cluster analysis☆

  • Junichi Yoshida

      Affiliations

    • Corresponding Author InformationAddress for correspondence: Dr. J. Yoshida, Department of Surgery, Shimonoseki City Hospital, 1-13-1 Koyo-cho, Shimonoseki 750, Japan.
    • Department of Surgery, National Shimonoseki Hospital, Shimonoseki 751, Japan
    • The Departments of Surgery I Kyushu University Faculty of Medicine, Fukuoka 812, Japan
    • ,
  • Takayoshi Nagata

      Affiliations

    • Department of Surgery, National Shimonoseki Hospital, Shimonoseki 751, Japan
    • ,
  • Yuko Nishioka

      Affiliations

    • Medical Informatics, Kyushu University Faculty of Medicine, Fukuoka 812, Japan
    • ,
  • Yoshiaki Nose

      Affiliations

    • Medical Informatics, Kyushu University Faculty of Medicine, Fukuoka 812, Japan
    • ,
  • Masao Tanaka

      Affiliations

    • The Departments of Surgery I Kyushu University Faculty of Medicine, Fukuoka 812, Japan

Accepted 5 June 1996.

Abstract 

Background. Outbreaks of multi-drug resistant Staphylococcus aureus over eight years were investigated to prevent future endemic. Methods. Isolates of multiresistant S. aureus underwent a cluster analysis combined with canonical discriminant analysis using bacteriologic biotyping and sensitivity to 21 drugs. Results. Of a total of 786 strains recovered from 155 in-patients, the specialty surgical ward (SW) exhibited 470 isolates (59.8%) and the general SW 214 (27.2%). Among six clusters formed, four clusters were predominant in the general SW. An ordination diagram from the canonical discriminant analysis revealed a distribution in which clusters were localized temporally (year) and spatially (ward). A yearly shift of clusters indicated emergence of a new phenotype of multiresistant S. aureus. Conclusions. The cluster analysis of isolates of multiresistant S. aureus using biotyping and sensitivity may supplement the classical method of tracing the spreading patterns of this microbe.

Keywords:  Methicillin-resistant Staphylococcus aureus, cluster analysis, biotype, antibiogram, nosocomial spread

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☆ Disclaimer: The opinions expressed in this article reflect those of the authors and are not to be construed as the opinions of the Ministry of Health and Welfare, nor of the Ministry of Science and Education, Japan.

PII: S0895-4356(96)00277-6

Journal of Clinical Epidemiology
Volume 49, Issue 12 , Pages 1447-1452, December 1996

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