Journal of Clinical Epidemiology
Volume 63, Issue 12 , Pages 1324-1331 , December 2010

A threshold regression model for recurrent exacerbations in chronic obstructive pulmonary disease

  • S.D. Aaron

      Affiliations

    • Ottawa Health Research Institute, Ottawa, Ontario, Canada K1H 8L6
    • Corresponding Author InformationCorresponding author. Division Head of Respiratory Medicine, The Ottawa Hospital, University of Ottawa, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6. Tel.: 613-739-6636; fax: 613-739-6807.
  • ,
  • T. Ramsay

      Affiliations

    • Ottawa Health Research Institute, Ottawa, Ontario, Canada K1H 8L6
  • ,
  • K. Vandemheen

      Affiliations

    • Ottawa Health Research Institute, Ottawa, Ontario, Canada K1H 8L6
  • ,
  • G.A. Whitmore

      Affiliations

    • Desautels Faculty of Management, McGill University, Montreal, Quebec, Canada H3A 1G5

,Accepted 29 May 2010.

References 

  1. Seemungal TAR, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha JA. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157:1418–1422
  2. Seemungal TAR, Donaldson GC, Bhowmik A, Jeffries DJ, Wedzicha JA. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;161:1608–1613
  3. Aaron SD, Vandemheen KL, Fergusson D, Maltais F, Bourbeau J, Goldstein R, et al. Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease. Ann Intern Med. 2007;146:545–555
  4. Aaron SD, Fergusson D, Marks GB, Suissa S, Vandemheen KL, Doucette S, et al. Counting, analyzing and reporting exacerbations of COPD in randomised controlled trials. Thorax. 2008;63:122–128
  5. Hurst JR, Donaldson GC, Quint JK, Goldring JJP, Baghai-Ravary R, Wedicha JA. Temporal clustering of exacerbations in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;179:369–374
  6. Suissa S. Statistical treatment of exacerbations in therapeutic trials of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173:842–846
  7. Lee M-LT, Whitmore GA. Threshold regression for survival analysis: modeling event times by a stochastic process reaching a boundary. Stat Sci. 2006;21:501–513
  8. Aalen OO, Borgan O, Gjessing HK. Survival and event history analysis: a process point of view (statistics for biology and health). New York: Springer; 2008;
  9. Lee M-LT, Whitmore GA, Laden F, Hart JE, Garshick E. A case-control study relating railroad worker mortality to diesel exhaust exposure using a threshold regression model. J Stat Plan Inference. 2009;139:1633–1642
  10. Lee M-LT, Whitmore GA, Chang M. A threshold regression mixture model for assessing treatment efficacy in a multiple myeloma clinical trial. J Biopharm Stat. 2008;18:1136–1149
  11. Lee M-LT, Whitmore GA. Proportional hazards and threshold regression: their theoretical and practical connections. Lifetime Data Anal. 2010;16:196–214
  12. Lee M-LT, Whitmore GA, Rosner B. Threshold regression for survival data with time-varying covariates. Stat Med. 2010;29:896–905
  13. Cook RJ, Lawless JF. The statistical analysis of recurrent events. New York: Springer; 2007;
  14. Ross SM. Stochastic processes. 2nd edition. New York: Wiley; 1996;

PII: S0895-4356(10)00196-4

doi: 10.1016/j.jclinepi.2010.05.007

Journal of Clinical Epidemiology
Volume 63, Issue 12 , Pages 1324-1331 , December 2010