Journal of Clinical Epidemiology
Volume 63, Issue 12 , Pages 1285-1286 , December 2010

The rhythm of chronic obstructive pulmonary disease exacerbations

  • John R. Hurst

      Affiliations

    • Corresponding Author InformationCorresponding author. Academic Unit of Respiratory Medicine, UCL Medical School, London NW3 2PF, London, UK. Tel.: +44-207-317-7510; fax: +44-207-472-6141.

,Accepted 4 April 2010.

References 

  1. Global Initiative for Chronic Obstructive Lung Disease . Available at www.goldcopd.comAccessed March 21, 2010
  2. Donaldson GC, Wedzicha JA. COPD exacerbations.1: Epidemiology. Thorax. 2006;61:164–168
  3. Hurst JR, Wedzicha JA. The biology of a chronic obstructive pulmonary disease exacerbation. Clin Chest Med. 2007;28:525–536
  4. Aaron SD, Fergusson D, Marks GB, Suissa S, Vandemheen KL, Doucette S, et al. Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium Counting, analysing and reporting exacerbations of COPD in randomised controlled trials. Thorax. 2008;63:122–128
  5. Suissa S. Statistical treatment of exacerbations in therapeutic trials of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173:842–846
  6. Hurst JR, Donaldson GC, Quint JK, Goldring JJP, Baghai-Ravary R, Wedzicha JA. Temporal clustering of exacerbations in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;179:369–374
  7. Roede BM, Bresser P, Bindels PJ, Kok A, Prins M, ter Riet G, et al. Antibiotic treatment is associated with reduced risk of a subsequent exacerbation in obstructive lung disease: a historical population based cohort study. Thorax. 2008;63:968–973
  8. Perera WR, Hurst JR, Wilkinson TMA, Sapsford RJ, Mullerova H, Donaldson GC, et al. Inflammatory changes, recovery and recurrence at COPD exacerbation. Eur Respir J. 2007;29:527–534
  9. Aaron SD, Ramsay T, Vandemheen, Whitmore GA. A threshold regression model for recurrent exacerbations in chronic obstructive pulmonary disease. J Clin Epidemiol. In press.
  10. Aaron SD, Vandemheen KL, Fergusson D, Maltais F, Bourbeau J, Goldstein R, et al. Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med. 2007;146:545–555
  11. Seemungal TA, Donaldson GC, Bhowmik A, Jeffries DJ, Wedzicha JA. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;161:1608–1613

PII: S0895-4356(10)00195-2

doi: 10.1016/j.jclinepi.2010.04.021

Journal of Clinical Epidemiology
Volume 63, Issue 12 , Pages 1285-1286 , December 2010

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