Journal of Clinical Epidemiology
Volume 63, Issue 12 , Pages 1283-1284, December 2010

N-of-1 clinical trials should be incorporated into clinical practice

  • Jesse A. Berlin

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +609-730-3006; fax: +609-730-7927.

Johnson & Johnson Pharmaceutical Research and Development, 1125 Trenton-Harbourton Road, PO Box 200, M/S TE3-15, Titusville, NJ 08560, USA

Accepted 30 May 2010. published online 30 August 2010.

Abstract 

N-of-1 clinical trials have the potential to contribute to individual patient management and to the accrual of important information about populations. Incorporating these studies into clinical practice will require creative thinking so as to maintain rigor without excessive disruption of routine care.

Keywords: Clinical trial design, N-of-1 clinical trials, Meta-analysis, Personalized medicine, Comparative effectiveness

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 The opinions expressed here are those of the author and do not necessarily represent those of Johnson & Johnson Pharmaceutical Research and Development.

PII: S0895-4356(10)00193-9

doi:10.1016/j.jclinepi.2010.05.006

Journal of Clinical Epidemiology
Volume 63, Issue 12 , Pages 1283-1284, December 2010

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