Journal of Clinical Epidemiology
Volume 64, Issue 5 , Pages 537-542 , May 2011

Prospectively screening for eligible patients was inaccurate in predicting patient recruitment of orthopedic randomized trials

  • Bauke W. Kooistra

      Affiliations

    • Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario L8L 2X2, Canada
    • Corresponding Author InformationCorresponding author. Division of Orthopaedic Surgery, Department of Surgery, McMaster University, 293 Wellington Street North, Suite 110, Hamilton, Ontario L8L 2X2, Canada. Tel.: 905-527-4322 ext. 44490; fax: 905-527-523-8781.
    • ,
  • Bernadette G. Dijkman

      Affiliations

    • Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario L8L 2X2, Canada
    • ,
  • Gordon H. Guyatt

      Affiliations

    • Department of Clinical Epidemiology & Biostatistics, McMaster University, Ontario L8L 2X2, Canada
    • ,
  • Sheila Sprague

      Affiliations

    • Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario L8L 2X2, Canada
    • Department of Clinical Epidemiology & Biostatistics, McMaster University, Ontario L8L 2X2, Canada
    • ,
  • Paul Tornetta III

      Affiliations

    • Department of Orthopaedic Surgery, Boston University, Boston, MA, USA
    • ,
  • Mohit Bhandari

      Affiliations

    • Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario L8L 2X2, Canada
    • Department of Clinical Epidemiology & Biostatistics, McMaster University, Ontario L8L 2X2, Canada

,Accepted 14 May 2010.

References 

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  2. Blanton S, Morris DM, Prettyman MG, McCulloch K, Redmond S, Light KE, et al. Lessons learned in participant recruitment and retention: the EXCITE trial. Phys Ther. 2006;86:1520–1533
  3. International Hip Fracture Research Cooperative. Available at www.ihfrc.caAccessed June 22, 2009
  4. SPRINT Investigators , Bhandari M, Guyatt G, Tornetta P, Schemitsch E, Swiontkowski M, et al Study to prospectively evaluate reamed intramedually nails in patients with tibial fractures (S.P.R.I.N.T.): study rationale and design. BMC Musculoskelet Disord. 2008;9:91–105
  5. Study to Prospectively Evaluate Reamed Intramedullary Nails in Patients with Tibial Fractures Investigators , Bhandari M, Guyatt G, Tornetta P, Schemitsch EH, Swiontkowski M, et al Randomized trial of reamed and unreamed intramedullary nailing of tibial shaft fractures. J Bone Joint Surg Am. 2008;90:2567–2578
  6. Haidich AB, Ioannidis JP. Patterns of patient enrollment in randomized controlled trials. J Clin Epidemiol. 2001;54:877–883
  7. Mapstone J, Elbourne D, Roberts I. Strategies to improve recruitment to research studies. Cochrane Database Syst Rev. 2007;18:MR000013
  8. Watson JM, Torgerson DJ. Increasing recruitment to randomised trials: a review of randomised controlled trials. BMC Med Res Methodol. 2006;19:34
  9. Abbas I, Rovira J, Casanovas J. Clinical trial optimization: Monte Carlo simulation Markov model for planning clinical trials recruitment. Contemp Clin Trials. 2007;28:220–231
  10. Sandvik L, Erikssen J, Mowinckel P, Rødland EA. A method for determining the size of internal pilot studies. Stat Med. 1996;30:1587–1590
  11. Arnold DM, Burns KE, Adhikari NK, Kho ME, Meade MO, Cook DJ. McMaster Critical Care Interest Group. The design and interpretation of pilot trials in clinical research in critical care. Crit Care Med. 2009;37(1 Suppl):S69–S74
  12. Gajewski BJ, Simon SD, Carlson SE. Predicting accrual in clinical trials with Bayesian posterior predictive distributions. Stat Med. 2008;15:2328–2340

PII: S0895-4356(10)00182-4

doi: 10.1016/j.jclinepi.2010.05.002

Journal of Clinical Epidemiology
Volume 64, Issue 5 , Pages 537-542 , May 2011

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