Journal of Clinical Epidemiology
Volume 63, Issue 3 , Pages 246-256, March 2010

Trial sequential analyses of meta-analyses of complications in laparoscopic vs. small-incision cholecystectomy: more randomized patients are needed

  • Frederik Keus

      Affiliations

    • The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    • The Department of Surgery, Diakonessenhuis, Utrecht, the Netherlands
    • Corresponding Author InformationCorresponding author. Department of Surgery, Diakonessenhuis, Bosboomstraat 1, 3582 KE Utrecht, The Netherlands. Tel.: +31-30-2-566-566x6054, +31-30-2-566-225; fax: +31-30-2569759.
    • ,
  • Jørn Wetterslev

      Affiliations

    • The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    • ,
  • Christian Gluud

      Affiliations

    • The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    • ,
  • Hein G. Gooszen

      Affiliations

    • Department of Surgery, University Medical Center, Utrecht, the Netherlands
    • ,
  • Cornelis J.H.M. van Laarhoven

      Affiliations

    • The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    • Department of Surgery, University Medical Center St. Radboud, Nijmegen, the Netherlands

Accepted 31 August 2009. published online 11 December 2009.

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 Funding: No funding was obtained for this study. All researchers were dependent on funding.

 Conflict of interest: All authors declare that there are no personal interests, no competing interests, and no funding interests. Therefore, the authors have nothing to declare.

 Guarantor of the article: F. Keus and J. Wetterslev had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

PII: S0895-4356(09)00278-9

doi:10.1016/j.jclinepi.2009.08.023

Journal of Clinical Epidemiology
Volume 63, Issue 3 , Pages 246-256, March 2010

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