Early stopping of randomized clinical trials for overt efficacy is problematic

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Volume 61, Issue 3 , Pages 241-246, March 2008

Dirk Bassler
- Department of Neonatology, University Children's Hospital, Tübingen, Germany
Victor M. Montori
- Knowledge and Encounter Research Unit, Division of Endocrinology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
Matthias Briel
- CLARITY Research Group, Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
- Basel Institute for Clinical Epidemiology, University Hospital, Basel, Switzerland
Paul Glasziou
- Centre for Evidence-Based Medicine, Department of Primary Health Care, University of Oxford, Oxford, UK
Gordon Guyatt
- CLARITY Research Group, Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
- Corresponding author. Department of Clinical Epidemiology and Biostatistics, Health Sciences Centre, Room 2C12, McMaster University, Hamilton, Ontario, Canada. Tel.: +905-525-9140 ext. 22900; fax: +905-524-3841.