Journal of Clinical Epidemiology
Volume 60, Issue 11 , Pages 1127-1131 , November 2007

Methodological issues in design and analysis of a matched case–control study of a vaccine's effectiveness

  • Linda M. Niccolai

      Affiliations

    • Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    • ,
  • Lorraine G. Ogden

      Affiliations

    • Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine and Health Sciences Center, Denver, CO, USA
    • ,
  • Catherine E. Muehlenbein

      Affiliations

    • Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208064, New Haven, CT 06520-8064, USA
    • ,
  • James D. Dziura

      Affiliations

    • Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208064, New Haven, CT 06520-8064, USA
    • Department of General Clinical Research Center, Yale University School of Medicine, New Haven, CT, USA
    • ,
  • Marietta Vázquez

      Affiliations

    • Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208064, New Haven, CT 06520-8064, USA
    • ,
  • Eugene D. Shapiro

      Affiliations

    • Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    • Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208064, New Haven, CT 06520-8064, USA
    • Department of General Clinical Research Center, Yale University School of Medicine, New Haven, CT, USA
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208064, New Haven, CT 06520-8064, USA. Tel.: 203-688-4555; fax: 203-785-3932.

,Accepted 16 February 2007.

References 

  1. Clemens JD, Shapiro ED. The pneumococcal vaccine controversy: are there alternatives to randomized clinical trials. Rev Infect Dis. 1984;6:589–600
  2. Shapiro ED. Case-control studies of the effectiveness of vaccines: validity and assessment of bias. Pediatr Infect Dis J. 2004;23:127–131
  3. Breslow NE, Day NE. Statistical methods in cancer research. The Analysis of Case-control Studies. Vol. 1. Lyon: World Health Organization; 1980;
  4. Schlesselman JJ. Case-control studies: design, conduct, analysis. New York: Oxford University Press; 1982;
  5. Vázquez M, LaRussa PS, Gershon AA, Steinberg SP, Freudigman K, Shapiro ED. Effectiveness of varicella vaccine in clinical practice. N Engl J Med. 2001;344:955–960
  6. Vázquez M, LaRussa PS, Gershon AA, Niccolai LM, Muehlenbein CE, Steinberg SP, et al. Effectiveness of varicella vaccine over time. JAMA. 2004;291:851–855
  7. Rothman KJ, Greenland S. Modern Epidemiology. 2nd edition. Philadelphia PA: Lippincott-Raven Publishers; 1998;
  8. Tugwell BD, Lee LE, Gilette H, Lorber EM, Hedberg K, Cieslak PR. Chickenpox outbreak in a highly vaccinated school population. Pediatrics. 2004;113:455–459
  9. Galil K, Lee B, Strine T, Carraher C, Baughman AL, Eaton M, et al. Outbreak of varicella at a day-care center despite vaccination. NEJM. 2002;347:1909–1915
  10. Galil K, Fair E, Mountcastle N, Britz P, Seward J. Younger age at vaccination may increase risk of varicella vaccine failure. JID. 2002;186:102–105
  11. Haddad MB, Hill MB, Pavia AT, Green CE, Jumaan AO, De AK, et al. Vaccine effectiveness during a varicella outbreak among schoolchildren: Utah, 2002-2003. Pediatrics. 2005;115:1488–1493

PII: S0895-4356(07)00064-9

doi: 10.1016/j.jclinepi.2007.02.009

Journal of Clinical Epidemiology
Volume 60, Issue 11 , Pages 1127-1131 , November 2007

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