Journal of Clinical Epidemiology
Volume 59, Issue 8 , Pages 849-855 , August 2006

A user's guide to selecting a comorbidity index for clinical research

,Accepted 20 November 2005.

References 

  1. Linn BS, Linn MW, Lee G. Cumulative Illness Rating Scale. J Am Geriatr Soc. 1968;5:622–626
  2. Kaplan MH, Feinstein AR. The importance of classifying initial co-morbidity in evaluating the outcome of diabetes mellitus. J Chron Dis. 1974;27:387–404
  3. Charlson ME, Pompei P, Ales KL, Mackenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987;40:373–383
  4. Cleary PD, Greenfield S, Mulley HG, Pauker SG, Schroeder SH, Wexler L, et al. Variations in length of stay and outcomes for six medical and surgical conditions in Massachusets and California. JAMA. 1991;266:73–79
  5. de Groot V, Beckerman H, Lankhorst G, Bouter L. How to measure comorbidity: a critical review of available methods. J Clin Epidemiol. 2003;56:221–229
  6. Hall S, Rochon P, Streiner D, Paszat L, Groome PA, Rohland SL. Measuring comorbidity for survival studies in head and neck oncology. Laryngoscope. 2002;112:1988–1996
  7. Gijsen R, Hoeymans N, Schellevis FG, Ruwaard D, Satariano WA, van den Bos GA. Causes and consequences of comorbidity: a review. J Clin Epidemiol. 2001;54:661–674
  8. Greenfield S, Aronow HU, Elashoff RM, Watanabe D. Flaws in mortality data: the hazards of ignoring comorbid disease. JAMA. 1988;260:2253–2255
  9. Coebergh JW, Janssen-Heijnen ML, Post PN, Razenberg PP. Serious co-morbidity among unselected cancer patients newly diagnosed in the southeastern part of The Netherlands in 1993–1996. J Clin Epidemiol. 1999;52:1131–1136
  10. Hall SF, Groome PA, Rothwell D. The impact of comorbidity on survival in patients with squamous cell carcinoma of the head and neck. Head Neck. 2000;22:317–322
  11. Piccirillo JF, Tierney RM, Costas I, Grove L, Spitznagel EL. Prognostic importance of comorbidity in a hospital based cancer registry. JAMA. 2004;291:2441–2447
  12. Miller MD, Paradis CF, Houck PR, Mazumdar S, Stack JA, Rifai AH, et al. Rating chronic medical illness burden in geropsychiatric patients: application of the Cumulative Illness Rating Scale. Psychiatry Res. 1992;41:237–248
  13. Fletcher RH, Fletcher SW, Wagner EH. Clinical epidemiology: the essentials. 3rd ed.. Baltimore: Williams & Wilkins; 1996;
  14. Streiner DL, Norman G. Health measurement scales: a practical guide to their development and use. 3rd ed.. Oxford: Oxford University Press; 2003;
  15. Portney LG, Watkins MP. Statistical measures of reliability. In: Foundations of clinical research: applications to practice. 1st ed.. Norwalk, CT: Appleton & Lange; 1993;
  16. Rosner B. Fundamentals of biostatistics. 4th ed.. Belmont, CA: Duxbury Press; 1995;
  17. Shrout PE, Fleiss JL. Intraclass correlations: uses in assessing rater reliability. Psychol Bull. 1979;86:420–428
  18. McGraw KO, Wong SP. Forming inferences about some intraclass coefficients. Psychol Methods. 1996;1:30–46
  19. Chen AY, Daley J, Thibault GE. Angina patient's rating of current health and health without angina. Med Decis Making. 1996;16:169–177
  20. Extermann M, Overcash J, Lyman GH, Parr J, Balducci L. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol. 1998;16:1582–1587
  21. Kiefe CI, Funkhouser E, Fouad MN, May DS. Chronic disease as a barrier to breast and cervical cancer screening. J Gen Intern Med. 1998;13:357–365
  22. Waite K, Oddone E, Weinberger M, Samsa G. Lack of association between patients' measured burden of disease and risk for hospital readmission. J Clin Epidemiol. 1994;47:1229–1236
  23. Conwell Y, Forbes NT, Cox C, Caine ED. Validation of a measure of physical illness burden at autopsy: the Cumulative Illness Rating Scale. J Am Geriatr Soc. 1993;41:38–41
  24. Albertsen PC, Fryback DG, Storer BE, Kolon TF, Fine J. The impact of co-morbidity on life expectancy among men with localized prostate cancer. J Urol. 1996;156:127–132
  25. Firat S, Bousamra M, Gore E, Byhardt RW. Comorbidity and KPS are independent prognostic factors in stage 1 non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2002;52:1047–1057
  26. Krousel-Wood MA, Abdoh A, Re R. Comparing comorbid-illness indices assessing outcome variation: the case of prostatectomy. J Gen Intern Med. 1996;11:32–38
  27. Newschaffer CJ, Bush TL, Penberthy LT. Comorbidity measurement in elderly female breast cancer patients with administrative and medical records data. J Clin Epidemiol. 1997;50:725–733
  28. Krongrad A, Lai H, Lai S. Variation in prostate cancer survival explained by significant prognostic factors. J Urol. 1997;158:1487–1490
  29. Schemper M, Stare J. Explained variation in survival analysis. Stat Med. 1996;15:1999–2012
  30. Miller MD, Towers A. A manual of guidelines for scoring the Cumulative Illness Rating Scale for Geriatrics (CIRS-G). Pittsburgh, PA: University of Pittsburgh; 1991;
  31. Greenfield S, Apolone G. Assessment of comorbidity: the Index of Co-Existent Disease. 1991.
  32. Piccirillo J, Johnson A, Claybour , Littenberg B, et al. Comorbidity coding book. St. Louis: University of Washington School of Medicine; 2002;
  33. Weiss NS. Clinical epidemiology: the study of the outcome of illness. 1st ed.. New York: Oxford University Press; 1986;

PII: S0895-4356(05)00436-1

doi: 10.1016/j.jclinepi.2005.11.013

Journal of Clinical Epidemiology
Volume 59, Issue 8 , Pages 849-855 , August 2006