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Journal of Clinical Epidemiology
Volume 59, Issue 3
, Pages 224-233
, March 2006
An unadjusted NNT was a moderately good predictor of health benefit
References
- . An assessment of clinically useful measures of the consequences of treatment. N Engl J Med. 1988;318:1728–1733
- . Evidence-based medicine: how to practise and teach EBM. 2nd ed.. Edinburgh: Churchill Livingstone; 2000;
- . Evidence-Based Medicine Working Group. Users' guides to the medical literature: XX. Integrating research evidence with the care of the individual patient. JAMA. 2000;283:2829–2836
- . Number needed to treat (NNT). Ann Emerg Med. 1999;33:433–436
- . Measured enthusiasm: does the method of reporting trial results alter perceptions of therapeutic effectiveness?. Ann Intern Med. 1992;117:916–921
- . Therapeutic priorities of Canadian internists. CMAJ. 1990;142:329–333
- . Reporting number needed to treat and absolute risk reduction in randomized controlled trials. JAMA. 2002;287:2813–2814
- . Using numerical results from systematic reviews in clinical practice. Ann Intern Med. 1997;126:712–720
- . Number needed to treat: easily understood and intuitively meaningful? Theoretical considerations and a randomized trial. J Clin Epidemiol. 2002;55:888–892
- . A randomized comparison of patients' understanding of number needed to treat and other common risk reduction formats. J Gen Intern Med. 2003;18:884–892
- . Numeracy and the medical student's ability to interpret data. Eff Clin Pract. 2002;5:35–40
- . A note on the number needed to treat. Control Clin Trials. 1999;20:439–447
- . How to estimate treatment effects from reports of clinical trials. II: Dichotomous outcomes. Aust J Physiother. 2000;46:309–313
- . A simple method for evaluating the clinical literature. Fam Pract Manag. 2004;11:47–52
- . How useful are cholinesterase inhibitors in the treatment of Alzheimer's disease? A number needed to treat analysis. Int J Geriatr Psychiatry. 2000;15:203–207
- NNT Tables [database on the Internet]. Toronto (ON): Centre for Evidence Based Medicine, University Health Network, 2003. Available at: http://www.cebm.utoronto.ca/glossary/nnts.htm#table.
- . The number needed to treat: a clinically useful measure of treatment effect. BMJ. 1995;310:452–454
- . When should an effective treatment be used? Derivation of the threshold number needed to treat and the minimum event rate for treatment. J Clin Epidemiol. 2001;54:253–262
- . Utilities and quality-adjusted life years. Int J Technol Assess Health Care. 1989;5:559–575
- . Cost-utility analysis: use QALYs only with great caution. CMAJ. 2003;168:433–434
- . The quality of reporting in published cost-utility analyses, 1976–1997. Ann Intern Med. 2000;132:964–972
- . Health care CBA/CEA: an update on the growth and composition of the literature. Med Care. 1993;31(7 Suppl):JS1–JS11JS18–149
- . Health care CBA and CEA from 1991 to 1996: an updated bibliography. Med Care. 1998;36(5 Suppl):MS1–MS9MS18–147
- . Economic outcome for intensive care of infants of birthweight 500–999 g born in Victoria in the post surfactant era. J Paediatr Child Health. 1997;33:202–208
- . Cost-effective models for flutamide for prostate carcinoma patients: are they helpful to policy makers?. Cancer. 1996;77:1854–1861
- . Estimates of the cost-effectiveness of a single course of interferon-alpha 2b in patients with histologically mild chronic hepatitis C. Ann Intern Med. 1997;127:855–865
- . Economic evaluation of neonatal intensive care of very-low-birth-weight infants. N Engl J Med. 1983;308:1330–1337
- . Adjuvant therapy for stage III colon cancer: economics returns to research and cost-effectiveness of treatment. J Natl Cancer Inst. 1994;86:424–430
- . Economic and health state utility determinations for schizophrenic patients treated with risperidone or haloperidol. J Clin Psychopharmacol. 1997;17:298–307
- . Evaluating the potential cost-effectiveness of stenting as a treatment for symptomatic single-vessel coronary disease: use of a decision-analytic model. Circulation. 1994;89:1859–1874
- . Cost-effectiveness of carotid endarterectomy in asymptomatic patients. J Vasc Surg. 1997;25:298–309discussion 310–1
- . Should the elderly receive chemotherapy for node-negative breast cancer? A cost-effectiveness analysis examining total and active life-expectancy outcomes. J Clin Oncol. 1993;11:777–782
- . Cost effectiveness of isoniazid chemoprophylaxis. In: Goldbloom RB, Lawrence RS editor. Preventing disease: beyond the rhetoric. New York: Springer-Verlag; 1990;p. 446–454
- . Model of complications of NIDDM. II. Analysis of the health benefits and cost-effectiveness of treating NIDDM with the goal of normoglycemia. Diabetes Care. 1997;20:735–744
- . Cost-effectiveness of the transdermal nicotine patch as an adjunct to physicians' smoking cessation counseling. JAMA. 1996;275:1247–1251
- . Cost-effectiveness of warfarin and aspirin for prophylaxis of stroke in patients with nonvalvular atrial fibrillation. JAMA. 1995;274:1839–1845
- . Cost-effectiveness of palliative chemotherapy in advanced gastrointestinal cancer. Ann Oncol. 1995;6:267–274
- . Management of childhood lead poisoning: clinical impact and cost-effectiveness. Med Decis Making. 1995;15:13–24
- . Efficacy and cost-effectiveness of autologous blood predeposit in patients undergoing radical prostatectomy procedures. Urology. 1994;44:226–231
- . Cost-effectiveness of cancer chemotherapy: an economic evaluation of a randomized trial in small-cell lung cancer. J Clin Oncol. 1988;6:1537–1547
- . Cognitive-educational treatment of fibromyalgia: a randomized clinical trial. II. Economic evaluation. J Rheumatol. 1996;23:1246–1254
- . A cost-effectiveness analysis of exercise as a health promotion activity. Am J Public Health. 1988;78:1417–1421
- . Cost utility of maintenance treatment of recurrent depression with sertraline versus episodic treatment with dothiepin. Pharmacoeconomics. 1994;5:249–268
- . Efficacy and cost-effectiveness of autologous bone marrow transplantation in metastatic breast cancer: estimates using decision analysis while awaiting clinical trial results. JAMA. 1992;267:2055–2061
- . Economic analysis of adjuvant interferon alfa-2b in high-risk melanoma based on projections from Eastern Cooperative Oncology Group 1684. J Clin Oncol. 1997;15:2351–2358
- . Preventing HIV/AIDS among high-risk urban women: the cost-effectiveness of a behavioral group intervention. Am J Public Health. 1996;86:1442–1445
- . An economic analysis of the Survival and Ventricular Enlargement (SAVE) Study: application to the United Kingdom. Pharmacoeconomics. 1997;12(2 Pt 1):182–192
- . A new decision model for cost-utility comparisons of chemotherapy in recurrent metastatic breast cancer. Pharmacoeconomics. 1996;9(Suppl 2):8–22
- . A cost-effectiveness model of thrombolytic therapy for acute myocardial infarction. J Gen Intern Med. 1995;10:321–330
- . Cost utility analysis of maintenance treatment for recurrent depression. Control Clin Trials. 1995;16:17–40
- . Cost-effectiveness of interferon-alpha and conventional chemotherapy in chronic myelogenous leukemia. Ann Intern Med. 1996;125:541–548
- . The cost-effectiveness of treating mild-to-moderate hypertension: a reappraisal. J Hypertens. 1991;9:199–208
- . Comparison of “accelerated” tissue plasminogen activator with streptokinase for treatment of suspected myocardial infarction. Med Decis Making. 1995;15:297–310
- . Cost-effectiveness of 6 and 12 months of interferon-alpha therapy for chronic hepatitis C. Ann Intern Med. 1997;127:866–874
- . A cost-effectiveness analysis of anterior temporal lobectomy for intractable temporal lobe epilepsy. J Neurosurg. 1997;87:20–28
- Victorian Infant Collaborative Study Group. The cost of improving the outcome for infants of birthweight 500–999 g in Victoria. J Paediatr Child Health. 1993;29:56–62
- . Cost-effectiveness of anterotemporal lobectomy in medically intractable complex partial epilepsy. Epilepsia. 1997;38:154–163
- . Chemonucleolysis versus surgical discectomy for sciatica secondary to lumbar disc herniation: a cost and quality-of-life evaluation. Pharmacoeconomics. 1994;6:453–463
- . A cost-utility analysis of second-line chemotherapy in metastatic breast cancer: docetaxel versus paclitaxel versus vinorelbine. Pharmacoeconomics. 1996;10:504–521
- . A study of the quality of life and cost-utility of renal transplantation. Kidney Int. 1996;50:235–242
- . Circumcision: a decision analysis of its medical value. Fam Med. 1991;23:587–593
- . Cost-effectiveness of thrombolysis: a randomized study of intravenous rt-PA in suspected myocardial infarction. Eur Heart J. 1992;13:2–8
- . Cost-effectiveness of lumbar discectomy for the treatment of herniated intervertebral disc. Spine. 1996;21:1048–1054discussion 1055
- . Cost-utility analysis of prophylactic treatment with oral ganciclovir for cytomegalovirus retinitis. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;16:15–21
- . Cost-effectiveness analysis of potential improvements to emergency medical services for victims of out-of-hospital cardiac arrest. Ann Emerg Med. 1996;27:711–720
- . Cost-utility analysis of melphalan plus prednisone with or without interferon-alpha 2b in newly diagnosed multiple myeloma: results from a randomised controlled trial. Pharmacoeconomics. 1997;12:89–103
- . Cost-effectiveness of carotid endarterectomy. Neurosurgery. 1996;38:237–244
- . A cost-utility analysis of second-line antibiotics in the treatment of acute otitis media in children. Clin Ther. 1996;18:160–182
- . Cost-utility analysis of paclitaxel in combination with cisplatin for patients with advanced ovarian cancer. Gynecol Oncol. 1997;66:454–463
- . Cost-effectiveness of ticlopidine in preventing stroke in high-risk patients. Stroke. 1994;25:1149–1156
- . Cost-effectiveness of chemoprophylaxis after occupational exposure to HIV. Arch Intern Med. 1997;157:1972–1980
- . Cost-effectiveness of HIV-prevention skills training for men who have sex with men. AIDS. 1997;11:347–357
- . Where now for saving lives?. Law Contemp Probl. 1976;40:5–45
- . Cesarean delivery for women presenting with genital herpes lesions: efficacy, risks, and costs. JAMA. 1993;270:77–82
- . Economic analysis of an immunosuppressive strategy in renal transplantation. Health Policy. 1988;9:75–89
- . FIRST Investigators. Flolan International Randomized Survival Trial. Results of the economic evaluation of the FIRST study: a multinational prospective economic evaluation. Int J Technol Assess Health Care. 1996;12:698–713
- . A cost-utility analysis of laser-assisted angioplasty for peripheral arterial occlusions. Int J Technol Assess Health Care. 1996;12:104–125
- . Cost-utility analysis of thrombolytic therapy. Eur Heart J. 1991;12:694–699
- . A cost-utility approach to the use of 5-fluorouracil and levamisole as adjuvant chemotherapy for Dukes' C colonic carcinoma. Med J Aust. 1993;158:319–322
- . Pulmonary artery catheterization in exacerbations of COPD requiring mechanical ventilation: a cost-effectiveness analysis. Respir Care. 1994;39:961–967
- . Primary prophylaxis of variceal bleeding in cirrhosis: a cost-effectiveness analysis. Gastroenterology. 1997;112:473–482
- . Quality adjusted life years added by treatment of obstructive sleep apnea. Sleep. 1994;17:52–60
- . Drug treatments for maintaining remission in Crohn's disease: a lifetime cost-utility analysis. Pharmacoeconomics. 1997;11:444–453
- . Cost-effectiveness of captopril therapy after myocardial infarction. J Am Coll Cardiol. 1995;26:914–919
- . Cost-effectiveness of ABMT in comparison with CHOP chemotherapy in patients with intermediate- and high-grade malignant non-Hodgkin's lymphoma (NHL). Bone Marrow Transplant. 1995;16:463–470
- . Cost effectiveness of prophylactic intravenous immune globulin in chronic lymphocytic leukemia. N Engl J Med. 1991;325:81–86
- . Cost-effectiveness of interferon-alpha 2b treatment for hepatitis B e antigen-positive chronic hepatitis B. Ann Intern Med. 1995;122:664–675
- . Pharmacoeconomic analysis of ondansetron versus metoclopramide for cisplatin-induced nausea and vomiting. Am J Hosp Pharm. 1994;51:1555–1563
- . Intravenous immunoglobulin for the prevention of infection in chronic lymphocytic leukemia: a randomized, controlled clinical trial. N Engl J Med. 1988;319:902–907
- . Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy: 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Lancet. 1992;339:1–15
- . An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med. 1993;329:673–682
- . Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N Engl J Med. 1994;330:820–825
- . Endarterectomy for asymptomatic carotid artery stenosis. JAMA. 1995;273:1421–1428
- . Case-control study of HIV seroconversion in health-care workers after percutaneous exposure to HIV-infected blood: France, United Kingdom, and United States, January 1988–Auguest 1994. MMWR Morb Mortal Wkly Rep. 1995;44:929–933
- . Interferon-alpha 2b added to melphalan-prednisone for initial and maintenance therapy in multiple myeloma: a randomized, controlled trial. Ann Intern Med. 1996;124:212–222
- . A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients. J Clin Psychopharmacol. 1993;13:25–40[Erratum in: J Clin Psychopharmacol 1993;13:149]
- EORTC GU Group and EORTC Data Center. Goserelin acetate and flutamide versus bilateral orchiectomy: a phase III EORTC trial (30853). Urology. 1993;42:119–129discussion 129–30
- Superiority of alternating non-cross-resistant chemotherapy in extensive small cell lung cancer. A multicenter, randomized clinical trial by the National Cancer Institute of Canada. Ann Intern Med. 1987;107:451–458
- . Controlled chemoprophylaxis trials in tuberculosis: a general review. Bibl Tuberc. 1970;26:28–106
- . Three-year outcomes for maintenance therapies in recurrent depression. Arch Gen Psychiatry. 1990;47:1093–1099
- . A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. N Engl J Med. 1989;321:501–507
- . Recent evidence on drug therapy of mild to moderate hypertension and decreased risk of coronary heart disease. Arch Intern Med. 1993;153:578–581
- . [Use of cyclosporin A after antilymphocyte serum in renal transplantation]. In French. Presse Med. 1985;14:2093–2096
- . The effects of HIV/AIDS intervention groups for high-risk women in urban clinics. Am J Public Health. 1994;84:1918–1922
- . Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol. 1996;14:7–17
- . The effects of drug treatment for hypertension on morbidity and mortality from cardiovascular disease: a review of randomized controlled trials. Prog Cardiovasc Dis. 1986;29(3 Suppl 1):99–118
- . Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med. 1996;334:1–6
- Experience of chronic intravenous epoprostenol infusion in end-stage cardiac failure: results of FIRST. [Abstract] Eur Heart J. 1994;15:36A
- . Effectiveness of 5-aminosalicylic acid for maintaining remission in patients with Crohn's disease: a meta-analysis. Am J Gastroenterol. 1994;89:692–698
- Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med. 1990;322:352–358
- . Effectiveness of emergency medical services for victims of out-of-hospital cardiac arrest: a metaanalysis. Ann Emerg Med. 1996;27:700–710
- . The Copenhagen AFASAK study. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. Lancet. 1989;1(8631):175–179
- SAVE Investigators. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival And Ventricular Enlargement trial. N Engl J Med. 1992;327:669–677
- . Long-term benefit of early thrombolytic therapy in patients with acute myocardial infarction: 5 year follow-up of a trial conducted by the Interuniversity Cardiology Institute of The Netherlands. J Am Coll Cardiol. 1989;14:1609–1615
- . Roche Cooperative Oral Ganciclovir Study Group. Oral ganciclovir for the prevention of cytomegalovirus disease in persons with AIDS. N Engl J Med. 1996;334:1491–1497
- . AIDS prevention in homosexual and bisexual men: results of a randomized trial evaluating two risk reduction interventions. AIDS. 1989;3:21–26
- Comparison of CHOP chemotherapy with autologous bone marrow transplantation for slowly responding patients with aggressive non-Hodgkin's lymphoma. N Engl J Med. 1995;332:1045–1051
- . Cognitive-educational treatment of fibromyalgia: a randomized clinical trial. I. Clinical effects. J Rheumatol. 1996;23:1237–1245
- . Lumbar disc herniation: a controlled, prospective study with ten years of observation. Spine. 1983;8:131–140
- . Signal detectability: the use of ROC curves and their analyses. Med Decis Making. 1991;11:102–106
- . Assessing test accuracy and its clinical consequences: a primer for receiver operating characteristic curve analysis. Ann Clin Biochem. 1993;30(Pt 6):521–539
- . Primer on medical decision analysis: Part 4. Analyzing the model and interpreting the results. Med Decis Making. 1997;17:142–151
PII: S0895-4356(05)00296-9
doi: 10.1016/j.jclinepi.2005.08.005
© 2006 Elsevier Inc. All rights reserved.
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Journal of Clinical Epidemiology
Volume 59, Issue 3
, Pages 224-233
, March 2006
