Journal of Clinical Epidemiology
Volume 58, Issue 6 , Pages 543-549, June 2005

Early extreme contradictory estimates may appear in published research: The Proteus phenomenon in molecular genetics research and randomized trials

  • John P.A. Ioannidis

      Affiliations

    • Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    • Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    • Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina 45110, Greece
    • Corresponding Author InformationCorresponding author: Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece. Tel.: +3026510-97807; fax: +3026510-97867.
    • ,
  • Thomas A. Trikalinos

      Affiliations

    • Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    • Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece

Accepted 8 October 2004. published online 19 April 2005.

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PII: S0895-4356(05)00023-5

doi:10.1016/j.jclinepi.2004.10.019

Journal of Clinical Epidemiology
Volume 58, Issue 6 , Pages 543-549, June 2005

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