Journal of Clinical Epidemiology
Volume 57, Issue 11 , Pages 1188-1195 , November 2004

A combination of serum low albumin and above-average cholesterol level was associated with excess mortality

  • Tomonori Okamura

      Affiliations

    • Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu City, Shiga, 520-2192 Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-77-548-2191; fax: +81-77-543-9732.
    • ,
  • Takehito Hayakawa

      Affiliations

    • Department of Public Health, Shimane University School of Medicine, Izumo, Japan
    • ,
  • Takashi Kadowaki

      Affiliations

    • Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu City, Shiga, 520-2192 Japan
    • ,
  • Yoshikuni Kita

      Affiliations

    • Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu City, Shiga, 520-2192 Japan
    • ,
  • Akira Okayama

      Affiliations

    • Department of Preventive Cardiology, National Cardiovascular Center, Osaka, Japan
    • ,
  • Paul Elliott

      Affiliations

    • Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, UK
    • ,
  • Hirotsugu Ueshima

      Affiliations

    • Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu City, Shiga, 520-2192 Japan
    • ,
  • for the NIPPON DATA80 Research Group

      Affiliations

    • Investigators and members of the research group are listed in references 18, 19, and 20.

,Accepted 13 February 2004.

References 

  1. Goldwasser P, Feldman J. Association of serum albumin and mortality risk. J Clin Epidemiol. 1997;50:693–703
  2. Phillips A, Shaper AG, Whincup PH. Association between serum albumin and mortality from cardiovascular disease, cancer, and other causes. [Erratum in: Lancet 1990;335:180.] Lancet. 1989;2:1434–1436
  3. Gillum RF, Makuc DM. Serum albumin, coronary heart disease, and death. Am Heart J. 1992;123:507–513
  4. Corti MC, Guralnik JM, Salive ME, Sorkin JD. Serum albumin level and physical disability as predictors of mortality in older persons. JAMA. 1994;272:1036–1042
  5. Fried LP, Kronmal RA, Newman AB, Bild DE, Mittelmark MB, Polak JF, et al. Risk factors for 5-year mortality in older adults. The Cardiovascular Health Study. JAMA. 1998;279:585–592
  6. Reuben DB, Ix JH, Greendale GA, Seeman TE. The predictive value of combined hypoalbuminemia and hypocholesterolemia in high functioning community-dwelling older persons: MacArthur Studies of Successful Aging. J Am Geriatr Soc. 1999;47:402–406
  7. Sahyoun NR, Jacques PF, Dallal G, Russell RM. Use of albumin as a predictor of mortality in community dwelling and institutionalized elderly populations. J Clin Epidemiol. 1996;49:981–988
  8. Klonoff-Cohen H, Barrett-Connor EL, Edelstein SL. Albumin levels as a predictor of mortality in the healthy elderly. J Clin Epidemiol. 1992;45:207–212
  9. Kuller LH, Eichner JE, Orchard TJ, Grandits GA, McCallum L, Tracy RP. The relation between serum albumin levels and risk of coronary heart disease in the Multiple Risk Factor Intervention Trial. Am J Epidemiol. 1991;134:1266–1277
  10. Weijenberg MP, Feskens EJM, Souverijn JHM, Kromhout D. Serum albumin, coronary heart disease risk, and mortality in an elderly cohort. Epidemiology. 1997;8:87–92
  11. Saito I, Folsom AR, Brancati FL, Duncan BB, Chambless LE, McGovern PG. Nontraditional risk factors for coronary heart disease incidence among persons with diabetes: the Atherosclerosis Risk in Communities (ARIC) Study. Ann Intern Med. 2000;133:81–91
  12. Nelson JJ, Liao D, Sharrett AR, Folsom AR, Chambless LE, Shahar E, et al. Serum albumin level as a predictor of incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol. 2000;151:468–477
  13. Corti MC, Salive ME, Guralnik JM. Serum albumin and physical function as predictors of coronary heart disease mortality and incidence in older persons. J Clin Epidemiol. 1996;49:519–526
  14. Gillum RF, Ingram DD, Makuc DM. Relation between serum albumin concentration and stroke incidence and death: the NHANES I Epidemiologic Follow-up Study. Am J Epidemiol. 1994;140:876–888
  15. Stamler J, Daviglus ML, Garside DB, Dyer AR, Greenland P, Neaton JD. Relationship between baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and longevity. JAMA. 2000;284:311–318
  16. Halliwell B, Gutteridge JM. The antioxidants of human extracellular fluids. Arch Biochem Biophys. 1990;280:1–8
  17. Krijgsman B, Papadakis JA, Ganotakis ES, Mikhailidis DP, Hamilton G. The effect of peripheral vascular disease on the serum levels of natural anti-oxidants: bilirubin and albumin. Int Angiol. 2002;21:44–52
  18. Hayakawa T, Okayama A, Ueshima H, Kita Y, Choudhury SR, Tamaki J. Prevalence of impaired activities of daily living and impact of stroke and lower limb fracture on it in Japanese elderly people. CVD Prev. 2000;3:187–194
  19. Sakata K, Hashimoto T, Ueshima H, Okayama A. Absence of an association between serum uric acid and mortality from cardiovascular disease: NIPPON DATA 80, 1980–1994. National Integrated Projects for Prospective Observation of Non-communicable Diseases and its Trend in the Aged. Eur J Epidemiol. 2001;17:461–468
  20. Okamura T, Kadowaki T, Hayakawa T, Kita Y, Okayama A, Ueshima H. What cause of mortality can we predict by cholesterol screening in the Japanese general population?. J Intern Med. 2003;253:169–180
  21. Nakamura M, Sato S, Shimamoto T. Improvement in Japanese clinical laboratory measurements of total cholesterol and HDL-cholesterol by the US Cholesterol Reference Method Laboratory Network. J Atheroscler Thromb. 2003;10:145–153
  22. Bittner D, McCleary M. The cupric-phenanthroline chelate in the determination of monosaccharides in whole blood. Am J Clin Pathol. 1963;40:423–424
  23. Law MR, Morris JK, Wald NJ, Hale AK. Serum albumin and mortality in the BUPA study. British United Provident Association. Int J Epidemiol. 1994;23:38–41
  24. Salive ME, Cornoni-Huntley J, Phillips CL, Guralnik JM, Cohen HJ, Ostfeld AM, et al. Serum albumin in older persons: relationship with age and health status. J Clin Epidemiol. 1992;45:213–221
  25. Danesh J, Collins R, Appleby P, Peto R. Association of C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA. 1998;279:1477–1482
  26. Bauer J, Herrmann F. Interleukin-6 in clinical medicine. Ann Hematol. 1991;62:203–210
  27. Rochling FA. Evaluation of abnormal liver tests. Clin Cornerstone. 2001;3:1–12
  28. Miller JP. Dyslipoproteinaemia of liver disease. Baillieres Clin Endocrinol Metab. 1990;4:807–832
  29. MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, et al. Blood pressure, stroke, and coronary heart disease. Part 1. Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet. 1990;335:765–774

PII: S0895-4356(04)00127-1

doi: 10.1016/j.jclinepi.2004.02.019

Journal of Clinical Epidemiology
Volume 57, Issue 11 , Pages 1188-1195 , November 2004

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