Journal of Clinical Epidemiology
Volume 57, Issue 11 , Pages 1124-1130 , November 2004

Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time

  • Thomas A. Trikalinos

      Affiliations

    • Institute for Clinical Care Research and Health Policy Studies, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    • Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    • ,
  • Rachel Churchill

      Affiliations

    • Health Services Research Department, Institute of Psychiatry, London, United Kingdom
    • ,
  • Marica Ferri

      Affiliations

    • Department of Epidemiology of Lazio Region, Rome, Italy
    • ,
  • Stefan Leucht

      Affiliations

    • Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany
    • ,
  • Arja Tuunainen

      Affiliations

    • Department of Psychiatry, University of Helsinki, Lapinlahti Hospital, Helsinki, Finland
    • ,
  • Kristian Wahlbeck

      Affiliations

    • STAKES National Research and Development Center for Welfare and Health, Helsinki, Finland
    • ,
  • John P.A. Ioannidis

      Affiliations

    • Institute for Clinical Care Research and Health Policy Studies, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    • Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    • Corresponding Author InformationCorresponding author. Tel: +30-2651-097807; fax: +30-2651-097867.
    • ,
  • for the EU-PSI project

      Affiliations

    • EU-PSI project membership is listed in the Acknowledgments.

,Accepted 13 February 2004.

References 

  1. Lau J, Schmid CH, Chalmers TC. Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care. J Clin Epidemiol. 1995;48:45–57discussion 59–60
  2. Mosteller F, Colditz GA. Understanding research synthesis (meta-analysis). Annu Rev Public Health. 1996;17:1–23
  3. Chalmers TC, Lau J. Changes in clinical trials mandated by the advent of meta-analysis. Stat Med. 1996;15:1263–1268discussion 1269–72
  4. Feinstein AR. Meta-analysis: statistical alchemy for the 21st century. J Clin Epidemiol. 1995;48:71–79
  5. Ioannidis J, Lau J. Evolution of treatment effects over time: empirical insight from recursive cumulative metaanalyses. Proc Natl Acad Sci U S A. 2001;98:831–836
  6. Cochrane Database of Systematic Reviews, in: Cochrane Collaboration. Cochrane Library, Issue 3, 2002. Oxford: Update Software. Available from http://update-software.com/abstracts/crgindex.htm.
  7. Cochrane Database of Systematic Reviews, in: Cochrane Collaboration. Mental Health Library, Issue 1, 2002. Oxford: Update Software. http://update-software.com/publications/mental/default.html
  8. The EU-PSI Project. Evidence-based Treatment in Mental Health and Optimised Use of Databases. Available from http://www.psitri.helsinki.fi/project/project.htm.
  9. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–748
  10. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188
  11. Lau J, Antman EM, Jimenez-Silva J, Kupelnick B, Mosteller F, Chalmers TC. Cumulative meta-analysis of therapeutic trials for myocardial infarction. N Engl J Med. 1992;327:248–254
  12. Ioannidis JP, Contopoulos-Ioannidis DG, Lau J. Recursive cumulative meta-analysis: a diagnostic for the evolution of total randomized evidence from group and individual patient data. J Clin Epidemiol. 1999;52:281–291
  13. Clarke M, Langhorne P. Revisiting the Cochrane Collaboration: meeting the challenge of Archie Cochrane—and facing up to some new ones. BMJ. 2001;323:821
  14. Thornley B, Adams C. Content and quality of 2000 controlled trials in schizophrenia over 50 years. BMJ. 1998;317:1181–1184
  15. Ioannidis JP. Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials. JAMA. 1998;279:281–286
  16. Juni P, Holenstein F, Sterne J, Bartlett C, Egger M. Direction and impact of language bias in meta-analyses of controlled trials: empirical study. Int J Epidemiol. 2002;31:115–123
  17. Hopewell S, Clarke M, Lusher A, Lefebvre C, Westby M. A comparison of handsearching versus MEDLINE searching to identify reports of randomized controlled trials. Stat Med. 2002;21:1625–1634
  18. Wahlbeck K, Tuunainen A, Ahokas A, Leucht S. Dropout rates in randomised antipsychotic drug trials. Psychopharmacology (Berl). 2001;155:230–233
  19. Woods SW, Ziedonis DM, Sernyak MJ, Diaz E, Rosenheck RA. Characteristics of participants and nonparticipants in medication trials for treatment of schizophrenia. Psychiatr Serv. 2000;51:79–84
  20. Gray JAM. Evidence-based healthcare. 1st edition. London: Churchill-Livingstone; 1997;
  21. Swingler GH, Volmink J, Ioannidis JP. Number of published systematic reviews and global burden of disease: database analysis. BMJ. 2003;327:1083–1084

PII: S0895-4356(04)00125-8

doi: 10.1016/j.jclinepi.2004.02.018

Journal of Clinical Epidemiology
Volume 57, Issue 11 , Pages 1124-1130 , November 2004

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