Journal of Clinical Epidemiology
Volume 56, Issue 7 , Pages 646-650 , July 2003

Digoxin therapy and the risk of primary cardiac arrest in patients with congestive heart failure: Effect of mild–moderate renal impairment

  • Thomas D. Rea

      Affiliations

    • Cardiovascular Health Research Unit, University of Washington, Department of Medicine, Metropolitan Park, 1730 Minor Avenue, East Tower, Seattle, WA 98101, USA
    • Corresponding Author InformationCorresponding author. Tel.: 206-287-2777; fax: 206-287-2662.
    • ,
  • David S. Siscovick

      Affiliations

    • Cardiovascular Health Research Unit, University of Washington, Department of Medicine, Metropolitan Park, 1730 Minor Avenue, East Tower, Seattle, WA 98101, USA
    • Department of Epidemiology, University of Washington, Box 357236 NE Pacific Street, Seattle, WA 98195, USA
    • ,
  • Bruce M. Psaty

      Affiliations

    • Department of Epidemiology, University of Washington, Box 357236 NE Pacific Street, Seattle, WA 98195, USA
    • Department of Health Services, University of Washington, Box 357660 NE Pacific Street, Seattle, WA 98195, USA
    • ,
  • Rachel M. Pearce

      Affiliations

    • Cardiovascular Health Research Unit, University of Washington, Department of Medicine, Metropolitan Park, 1730 Minor Avenue, East Tower, Seattle, WA 98101, USA
    • ,
  • Trivellore E. Raghunathan

      Affiliations

    • Institute for Social Research, University of Michigan, PO Box 1248, 426 Thompson Street, Ann Arbor, MI 481006, USA
    • ,
  • Eric A. Whitsel

      Affiliations

    • Department of Medicine, University of North Carolina, CB #7005 3033 Old Clinic Building, Chapel Hill, NC 27599, USA
    • ,
  • Leonard A. Cobb

      Affiliations

    • Cardiovascular Health Research Unit, University of Washington, Department of Medicine, Metropolitan Park, 1730 Minor Avenue, East Tower, Seattle, WA 98101, USA
    • ,
  • Sheila Weinmann

      Affiliations

    • Cardiovascular Health Research Unit, University of Washington, Department of Medicine, Metropolitan Park, 1730 Minor Avenue, East Tower, Seattle, WA 98101, USA
    • ,
  • Gail D. Anderson

      Affiliations

    • Department of Pharmacy, University of Washington, Box 357630 NE Pacific Street, Seattle, WA 98195, USA
    • ,
  • Patrick Arbogast

      Affiliations

    • Department of Biostatistics, Vanderbilt University, 1161 21st Avenue, Nashville, TN 37232, USA
    • ,
  • Danyu Lin

      Affiliations

    • Department of Biostatistics, University of North Carolina, CB #7420 3101 E McGavran-Greenburg Hall, Chapel Hill, NC 27599, USA

References 

  1. Stafford RS, Saglam D, Blumenthal D. National patterns of angiotensinconverting enzyme inhibitor use in congestive heart failure. Arch Intern Med. 1997;157:2460–2464
  2. Cohn JN. An explanation for varying views about digitalis efficacy in congestive heart failure. Cardiovasc Drugs Ther. 1989;3:19–20
  3. Hauptman PJ, Kelly RA. Digitalis. Circulation. 1999;99:1265–1270
  4. The Digitalis Investigation Group . The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med. 1997;336:525–533
  5. Smith TW. Digitalis: mechanism of action and clinical use. N Engl J Med. 1988;318:358–365
  6. Jelliffe RW, Brooker G. A nomogram for digoxin therapy. Am J Med. 1974;57:63–68
  7. Fisch C, Knoebel SB. Digitalis cardiotoxicity. J Am Coll Cardiol. 1985;5(Suppl A):91A–98A
  8. Marik PE, Fromm L. A case series of hospitalized patients with elevated digoxin levels. Am J Med. 1998;105:110–115
  9. Report of the Joint International Society and Federation Task Force of Cardiology. World Health Organization Task Force on Standardization of Clinical Nomenclature. Nomenclature and criteria for diagnosis of ischemic heart disease. Circulation. 1979;59:607–609
  10. Siscovick DS. Challenges in cardiac arrest research: data collection to assess outcomes. Ann Emerg Med. 1993;22:92–98
  11. Smith HW. Diseases of the kidney and urinary tract. In: The kidney: structure and function in health and disease. New York: Oxford Univ Press; 1951;p. 836–887
  12. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41
  13. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med. 1999;130:461–470
  14. Knight EL, Glynn RJ, McIntyre KM, Mogun H, Avorn J. Predictors of decreased renal function in patients with heart failure during angiotensin-converting enzyme inhibitor therapy: results from the studies of left ventricular dysfunction. Am Heart J. 1999;138:849–855
  15. Philbin EF, Santuella RN, Rocco TA. Angiotensin-converting enzyme inhibitor use in older patients with heart failure and renal dysfunction. J Am Geriatr Soc. 1999;47:302–308
  16. Surawicz B. Factors affecting tolerance to digitalis. J Am Coll Cardiol. 1985;5:69A–81A
  17. Bakris GL, Weir MR. Angiotensin-converting enzyme inhibitor—associated elevations in serum creatinine: is this a cause for concern?. Arch Intern Med. 2000;160:685–693

PII: S0895-4356(03)00075-1

doi: 10.1016/S0895-4356(03)00075-1

Journal of Clinical Epidemiology
Volume 56, Issue 7 , Pages 646-650 , July 2003

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