Journal of Clinical Epidemiology
Volume 56, Issue 1 , Pages 1-9 , January 2003

Gastric cancer epidemiology and risk factors

  • Jon R. Kelley

      Affiliations

    • Department of Veterans' Affairs, Commonwealth of Australia, G.P.O. Box 651, Brisbane Queensland 4001, Australia
  • ,
  • John M. Duggan

      Affiliations

    • Corresponding Author InformationCorresponding author. Princeton Medical Centre, 60 Lindsay Street, Hamilton, NSW, 2303, Australia. Tel.: 61 2 49 61 2090; fax: 61 2 49 62 3443.
    • Repatriation Medical Authority, Commonwealth of Australia, G.P.O. Box 1014, Brisbane Queensland, Australia
    • Discipline of Clinical Epidemiology and Biostatistics, Faculty of Medicine and Health Science, University of Newcastle, Pacific Street, Newcastle, NSW 2300, Australia

Received 30 May 2001 ,Revised 26 June 2002 ,Accepted 19 July 2002.

References 

  1. Howson CP, Hiyama T, Wynder EL. The decline of gastric cancer (epidemiology of an unplanned triumph). Epidemiol Rev. 1986;8:1–27
  2. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer. 1993;54:594–606
  3. Pisani P, Parkin DM, Ferlay J. Estimates of worldwide mortality from eighteen major cancers in 1985. Implications for prevention, and projections of future burden. Int J Cancer. 1993;54:891–903
  4. Jass JR. Tumours of the stomach. In:  McGee J,  O'D Isaacson PG,  Wright NA editor. Oxford textbook of pathology. Oxford: Oxford University Press;; 1992;p. 1165–1173
  5. Lauren P. The two histological main types of gastric carcinoma (diffuse and so-called intestinal-type carcinoma: an attempt at a histoloclinical classification). Acta Pathol Microbiol Scand. 1965;64:31–49
  6. Parkin DM, Whelan SL, Ferlay J, et al.  Cancer incidence in five continents, vol VII. Lyon: International Agency for Research on Cancer;; 1997; p. 822–3.
  7. Parkin DM, Whelan SL, Ferlay J, et al.  Cancer incidence in five continents, vol VII. Lyon: International Agency for Research on Cancer;; 1997; p. 922–4.
  8. Munoz N, Correa P, Cuello C, et al.  Histological types of gastric carcinoma in high and low risk areas. Int J Cancer. 1968;3:809–818
  9. Sipponen P, Javri O, Kekki M, et al.  Decreased incidences of intestinal and diffuse types of gastric carcinoma in Finland during a 20-year period. Scand J Gastroenterol. 1987;22:865–871
  10. Haenszel W, Kurihara M. Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J Natl Cancer Inst. 1968;40:43–68
  11. IARC Unit of Descriptive Epidemiology. WHO cancer mortality databank. Cancer Mondial. www-dep.iarc.fr/dataava/globocan/who.htm; 2001.
  12. Powell J, McConkey CC. The rising trend in oesophageal adenocarcinoma and gastric cardia. Eur J Cancer Prev. 1992;1:265–269
  13. Zheng T, Mayne ST, Holford TR, et al.  The time trend and age-period-cohort effects in incidence of adenocarcinoma of the stomach in Connecticut from 1955–1989. Cancer. 1993;72:330–340
  14. Blot WJ, Devesa SS, KIneller RW, et al.  Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA. 1991;265:1287–1289
  15. Wang HL, Antonioli DA, Goldman H. Comparative features of esophageal and gastric adenocarcinomas. Recent changes in type and frequency. Hum Pathol. 1986;17:482–487
  16. Pera M, Cameron AJ, Trastek VF, Carpenter HA, Zinmeister AR. Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gastroenterology. 1993;104:510–513
  17. Hannsson LE, Sparun P, Nyrun O. Increasing incidence of both major histological types of esophageal carcinomas among men in Sweden. Int J Cancer. 1993;54:402–407
  18. Lord RVN, Law MG, Ward RL, Giles GG, Thomas RJS, Thursfield V. Rising Incidence of oesophageal adenocarcinoma in men in Australia. J Gastroenterol Hepatol. 1998;13:356–362
  19. Levi F, La Vecchia C. Adenocarcinoma of the esophagus in Switzerland. JAMA. 1991;265:2960; [letter]
  20. Lagergren J, Bergstrom R, Lindgren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999;340:825–831
  21. Lagergren J, Bergstrom R, Nyren O. Association between body mass and adenocarcinoma of the oesophagus and gastric cardia. Ann Intern Med. 1999;130:883–890
  22. Chow WH, Blot WJ, Vaughan TL, et al.  Body mass index and the risk of adenocarcinoma of the esophagus and gastric cardia. J Natl Cancer Inst. 1998;90:150–155
  23. Terry P, Lagergren J, Ye W, Wolk F, Nyren O. Inverse association between intake of cereal fibre and risk of gastric cardia cancer. Gastroenterology. 2001;120:387–391
  24. Mowat C, Carswell A, McColl KEI. Omeprazole lowers gastric juice ascorbic acid and elevates gastric juice nitrite concentrations. Gut 1998(Suppl)42:A67.
  25. Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;i:1273–1277
  26. International Agency for Research on Cancer . Schistosomes, liver flukes and Helicobacter pylori. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 61. Lyon: International Agency for Research on Cancer;; 1994;
  27. The Eurogast Study Group . An international association between Helicobacter pylori infection and gastric cancer. Lancet. 1993;341:1359–1362
  28. Banatvala N, Mayo K, Megraud F, et al.  The cohort effect and Helicobacter pylori. J Infect Dis. 1993;168:219–221
  29. Webb PM, Forman D. Helicobacter pylori as a risk factor for cancer. Baillieres Clin Gastroenterol. 1995;9:563–582
  30. Sipponen P, Kosunen TU, Valle J, et al.  Helicobacter pylori infection and chronic gastritis in gastric cancer. J Clin Pathol. 1992;45:319–323
  31. Kikuchi S, Wada O, Nakajima T, et al.  Serum anti-Helicobacter pylori antibody and gastric carcinoma among young adults. Cancer. 1995;75:2789–2793
  32. Asaka M, Kimura T, Kato M, et al.  Possible role of Helicobacter pylori infection in early gastric cancer development. Cancer. 1994;73:2691–2694
  33. Lin JT, Wang JT, Wang TH, et al.  Helicobacter pylori infection in a randomly selected population, healthy volunteers, and patients with gastric ulcer and gastric adenocarcinoma. A seroprevalence study in Taiwan. Scand J Gastroentol. 1993;28:1067–1072
  34. Kuipers EJ, Gracia-Casanova M, Pena AS, et al.  Helicobacter pylori serology in patients with gastric carcinoma. Scand J Gastroenterol. 1993;28:433–437
  35. Talley JN, Zinsmeister AR, Weaver A, et al.  Gastric adenocarcinoma and Helicobacter pylori infection. J Natl Cancer Inst. 1991;83:1734–1739
  36. Hansson LE, Engstrand L, Nyren O, et al.  Helicobacter pylori infection (independent risk indicator of gastric adenocarcinoma). Gastroenterology. 1993;105:1098–1103
  37. Parsonnet DM, Friedman GT, Vandersteen DP, et al.  Helicobacter pylori infection and the risk of gastric cancer. N Engl J Med. 1991;325:1127–1131
  38. Nomura A, Stemmernamn GN, Chyou PH, et al.  Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 1991;325:1132–1136
  39. Forman D, Newell DG, Fullerton F, Yarnell JW, Stacey AR, Wald N, et al.  Association between infection with Helicobacter pylori and risk of gastric cancer; evidence of a prospective investigation. BMJ. 1991;302:1302–1305
  40. Nomura AMY, Stemmermann GN, Chyou P-H. Gastric cancer among the Japanese in Hawaii. Jpn J Cancer Res. 1995;86:916–923
  41. Forman D, Webb P, Parsonnet J. Helicobacter pylori and gastric cancer. Lancet. 1994;343:243–244
  42. Danesh J. Helicobacter pylori and gastric cancer; systematic review of epidemiological studies. Aliment Pharmacol Ther. 1999;13:851–856
  43. Eslick GD, Lim LL, Byles JE, et al.  Association of Helicobacter pylori infection with gastric carcinoma (a meta-analysis). Am J Gastroenterol. 1999;94:2373–2379
  44. Siman JH, Forsgren A, Berglund G, et al.  Association between Helicobacter pylori and gastric carcinoma in the city of Malmo, Sweden. A prospective study. Scand J Gastroenterol. 1997;32:1215–1221
  45. Kuipers EJ, Uyterlinde AM, Pena AS, et al.  Long-term sequelae of Helicobacter pylori gastritis. Lancet. 1995;345:1525–1528
  46. Valle J, Kekki M, Sipponen P, et al.  Long-term course and consequences of Helicobacter pylori gastritis. Results of a 32 year follow up study. Scand J Gastroenterol. 1996;31:546–550
  47. Siurala M, Sipponen P, Kekki M. Chronic gastritis (dynamic and clinical aspects). Scand J Gastroenterol. 1985;109(Suppl):S69–S76
  48. Sipponen P. Atrophic gastritis as a premalignant condition. Ann Med. 1989;21:287–290
  49. Sipponen P, Riihela M, Hyvarinen H, et al.  Chronic nonatrophic (“superficial”) gastritis increases the risk of gastric carcinoma. A case–control study. Scand J Gastroenterol. 1994;29:336–340
  50. Sipponen P, Kekki M, Haapakoski J, et al.  Gastric cancer risk in chronic atrophic gastritis (statistical calculations of cross-sectional data). Int J Cancer. 1985;35:173–177
  51. Parsonnet J, Friedman DG, Orentreich N, Vogelman . Risk of gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Lancet. 1997;40:297–301
  52. Ponzetto A, Soldati T, deGuili M. Helicobacter pylori screening and gastric cancer (letter). Lancet. 1996;348:758
  53. Isaacson PG. Gastric lymphoma and Helicobacter pylori. N Engl J Med. 1994;330:1310–1311
  54. Isaacson PG. Recent developments in our understanding of gastric lymphomas. Am J Surg Pathol. 1996;20(Suppl):S1–S7
  55. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, et al.  Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet. 1991;338:1175–1176
  56. Parsonnet J, Hansen S, Rodriguez L, et al.  Helicobacter pylori infection and gastric lymphoma. N Engl J Med. 1994;330:1267–1271
  57. Wotherspoon AC, Doglioni C, Diss TC, et al.  Regression of primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993;342:575–577
  58. Bayerdorffer E, Neubauer A, Rudolph B, et al.  Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. Lancet. 1995;345:1591–1594
  59. Cammarota G, Montalto M, Tursi A, et al.  Helicobacter pylori reinfection and rapid relapse of low-grade B-cell gastric. Lancet. 1995;345:192
  60. Stalnikowicz R, Benbassat J. Risk of gastric cancer after gastric surgery for benign disorders. Arch Intern Med. 1990;150:2022–2026
  61. Tersmette AC, Giardiello FM, Tytgat GN, et al.  Carcinogenesis after remote peptic ulcer surgery (the long-term prognosis of partial gastrectomy). Scand J Gastroenterol. 1995;212(Suppl):96–99 S
  62. Fisher SG, Davis F, Nelson R, et al.  A cohort study of stomach cancer risk in men after gastric surgery for benign disease. J Natl Cancer Inst. 1993;85:1303–1310
  63. Tersmette AC, Offerhaus GJ, Tersmette KW, et al.  Meta-analysis of the risk of gastric stump cancer (detection of high risk patient subsets for stomach cancer after remote partial gastrectomy for benign condition). Cancer Res. 1990;50:6486–6489
  64. Molloy RM, Sonnenberg A. Relation between gastric cancer and previous peptic ulcer disease. Gut. 1997;40:247–252
  65. Lee S, Iida M, Yao T, et al.  Risk of gastric cancer in patients with non-surgically treated peptic ulcer. Scand J Gastroenterol. 1990;25:1223–1226
  66. Hansson LE, Nyren O, Hsing AW, et al.  The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 1996;335:242–249
  67. Hole DJ, Quigley EM, Gillis CR, et al.  Peptic ulcer and cancer (an examination of the relationship between chronic peptic ulcer and gastric carcinoma). Scand J Gastroenterol. 1987;22:17–23
  68. Parsonnet J. Helicobacter pylori in the stomach—a paradox unmasked. N Engl J Med. 1996;335:278–280
  69. Uemura N, Okamoto S, Yamamoto S, et al.  Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345:784–789
  70. Kono S, Hirohata T. Nutition and stomach cancer. Cancer Causes Control. 1996;7:41–55
  71. Neugut AI, Hayek M, Howe G. Epidemiology of gastric cancer. Semin Oncol. 1996;23:281–291
  72. Blot WJ, Li JY, Taylor PR, et al.  Nutrition intervention trials in Linxian, China (supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population). J Natl Cancer Inst. 1993;85:1483–1491
  73. Joossens JV, Hill MJ, Elliott P, et al.  Dietary salt, nitrate and stomach cancer mortality in 24 countries. Int J Epidemiol. 1996;24:494–504
  74. Lee JK, Park BJ, Yoo KY, et al.  Dietary factors and stomach cancer (a case–control study in Korea). Int J Epidemiol. 1995;24:33–41
  75. Hansson LE, Nyren O, Bergstrom R, et al.  Diet and risk of gastric cancer. A population-based case–control study in Sweden. Int J Cancer. 1993;55:181–189
  76. Ramon JM, Serra L, Cerdo C, et al.  Dietary factors and gastric cancer risk. A case–control study in Spain. Cancer. 1993;71:1731–1735
  77. Boeing H, Jedrychowski W, Wahrendorf J, et al.  Dietary risk factors in intestinal and diffuse types of stomach cancer (a multicentre case–control study in Poland). Cancer Causes Control. 1991;2:227–233
  78. Graham S, Haughey B, Marshall J, et al.  Diet in the epidemiology of gastric cancer. Nutr Cancer. 1990;13:19–34
  79. Buiatti E, Palli D, Decarli A, et al.  A case–control study of gastric cancer and diet in Italy. Int J Cancer. 1989;44:611–616
  80. Kono S, Hirohata T. Nutrition and stomach cancer. Cancer Causes Control. 1996;7:41–55
  81. Buiatti E, Palli D, Decarli A, et al.  A case–control study of gastric cancer and diet in Italy. II. Association with nutrients. Int J Cancer. 1990;45:896–901
  82. Gonzalez CA, Riboli E, Badosa J, et al.  Nutritional factors and gastric cancer in Spain. Am J Epidemiol. 1994;139:466–473
  83. La Vecchia C, Ferraroni M, D'Avanzo B, et al.  Selected micronutrient intake and the risk of gastric cancer. Cancer Epidemiol Biomarkers Prev. 1994;3:393–398
  84. Hansson LE, Nyren O, Bertstrom R, et al.  Nutrients and gastric cancer risk. A population-based case–control study in Sweden. Int J Cancer. 1994;57:638–644
  85. Dixon ME. Commentary (role of Helicobacter pylori on gastric mucosal damage, gastric cancer and gastric MALT lymphona). Gastroenterology. 1997;113:565–566
  86. Thompson DE, Mabuchi K, Ron E, et al.  Cancer incidence in atomic bomb survivors. Part II (solid tumors, 1958–1987). Radiat Res. 1994;137:S17–S67
  87. Griem ML, Kleinerman RA, Boice JD, et al.  Cancer following radiotherapy for peptic ulcer. J Natl Cancer Inst. 1994;86:842–849
  88. Moller H, Mellemgaard A, Jacobsen GK, et al.  Incidence of second primary cancer following testicular cancer. Eur J Cancer. 1993;29A:672–676
  89. van Leeuwen FE, Stiggelbout AM, van den Belt-dusebout AW, et al.  Second cancer risk following testicular cancer (a follow-up study of 1,909 patient). J Clin Oncol. 1993;11:415–424
  90. Wang J-X, Inskip PD, Boice JD, et al.  Cancer Incidence among medical diagnostic X-ray workers in China, 1950 to 1985. Int J Cancer. 1990;45:889–895
  91. Smith PG, Doll R. Mortality from cancer and all causes among British radiologist. Br J Radiol. 1981;54:187–194
  92. Matanoski GM, Seltser R, Sartwell PE, et al.  The current mortality rates of radiologists and other physician specialists (specific causes of death). Am J Epidemiol. 1975;101:199–210
  93. Hsing A, Hansson L, McLaughlin J, et al.  Pernicious anaemia and subsequent cancer (a population based cohort study). Cancer. 1993;71:745–750
  94. Hansson LE, Baron J, Nyren O, et al.  Tobacco, alcohol and the risk of gastric cancer. A population-based case–control study in Sweden. Int J Cancer. 1994;57:26–31
  95. Nomura A, Grove J, Stemmermann G, et al.  A prospective study of stomach cancer and its relation to diet, cigarettes and alcohol consumption. Cancer Res. 1990;50:627–631
  96. Engeland A, Andersen A, Haldorsen T, et al.  Smoking habits and risk of cancers other than lung cancer (28 years' follow-up of 26,000 Norwegian men and women). Cancer Causes Control. 1996;7:497–506
  97. Doll R, Peto R, Wheatley K, et al.  Mortality in relation to smoking (40 years' observations on male British doctors). BMJ. 1994;309:901–911
  98. McLaughlin JK, Hrubec Z, Blot WJ, et al.  Smoking and cancer mortality among US Veterans (a 26 year follow-up). Int J Cancer. 1995;60:190–193
  99. Ji BT, Chow WH, Yang G, et al.  The influence of cigarette smoking, alcohol, and green tea consumption of the risk of carcinoma of the cardia and distal stomach in Shanghai. China. Cancer. 1996;77:2449–2457
  100. Jedrychowski W, Boeing H, Wahrendorf J, et al.  Vodka consumption, tobacco smoking and risk of gastric cancer in Poland. Int J Epidemiol. 1993;22:606–613
  101. Kabat GC, Ng SK, Wynder EL. Tobacco, alcohol intake, and diet in relation to adenocarcinoma of the esophagus and gastric cardia. Cancer Causes Control. 1993;4:123–132
  102. Vaughan TL, Davis S, Kristal A, et al.  Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia (adenocarcinoma versus squamous cell carcinoma). Cancer Epidemiol Biomarkers Prev. 1995;4:85–92
  103. Gammon MD, Schoenberg JB, Ahsan H, et al.  Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst. 1997;89:1277–1284
  104. Unakami M, Hara M, Fukuchi S, et al.  Cancer of the gastric cardia and the habit of smoking. Acta Pathol Jpn. 1989;39:420–424
  105. Franceschi S, La Vecchia C. Alcohol and the risk of cancers of the stomach and colon-rectum. Dig Dis. 1994;12:276–289
  106. Palli D, Bianchi S, Decarli A, et al.  A case–control study of cancers of the gastric cardia in Italy. Br J Cancer. 1992;65:263–266
  107. Guo W, Blot WJ, Li JY, et al.  A nested case–control study of oesophageal and stomach cancers in the Linzian nutrition intervention trial. Int J Epidemiol. 1994;23:444–450
  108. Gray JR, Coldman AJ, MacDonald WC. Cigarette and alcohol use in patients with adenocarcinoma of the gastric cardia or lower esophagus. Cancer. 1992;69:2227–2231
  109. Frumkin H, Berlin J. Asbestos exposure and gastrointestinal malignancy—review and meta-analysis. Am J Indust Med. 1988;14:79–95
  110. Cocco P, Palli D, Buiatti E, et al.  Occupational exposures as risk factors for gastric cancer in Italy. Cancer Causes Control. 1994;5:241–248
  111. Zandjani F, Hogsaet B, Andersen A, et al.  Incidence of cancer among nitrate fertilizer workers. Int Arch Occup Environ Health. 1994;66:189–193
  112. Andersen A, Glattre E, Johansen BV. Incidence of cancer among lighthouse keepers exposed to asbestos in drinking water. Am J Epidemiol. 1993;138:682–687
  113. de Klerk NH, Armstrong BK, Musk AW, et al.  Cancer mortality in relation to measures of occupational exposure to crocidolite at Wittenoom Gorge in Western Australia. Br J Indust Med. 1989;46:529–536
  114. Palli D, Galli M, Caporaso NE, et al.  Family history and risk of stomach cancer in Italy. Cancer Epidemiol Biomarkers Prev. 1994;3:15–18
  115. La Vechhia C, Negri E, Franchescki S, et al.  A family history and the risk of stomach and colorectal cancer. Cancer. 1992;70:50–55
  116. Lissowska J, Groves FD, Sobin LH, et al.  Family history and risk of stomach cancer in Warsaw, Poland. Eur J Cancer Prev. 1999;8:223–227
  117. Lichtenstein P, Holm NV, Verkasald PK, et al.  Environmental and heritable factors in the causation of cancer. Analysis of cohorts of twins from Sweden, Denmark and Finland. N Engl J Med. 2000;343:78–85
  118. Kwiatkowski D. Susceptibility to infection. BMJ. 2000;321:1061–1065
  119. Schlesseman JJ. Case–control studies. Design, conduct, analysis. New York: Oxford University Press;; 1982;
  120. Labenz J, Blum A, Bayerdorffer E, et al.  Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux oesophagitis. Gastroenterology. 1997;112:1442–1447

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Journal of Clinical Epidemiology
Volume 56, Issue 1 , Pages 1-9 , January 2003