Journal of Clinical Epidemiology
Volume 54, Issue 12, Supplement 1 , Pages S44-S52 , December 2001

Neuropsychiatric aspects of HIV infection among older adults

  • C.H Hinkin

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, 760 Westwood Plaza, Room C8-747, Los Angeles, CA 90024, USA
    • Corresponding Author InformationCorresponding author. Tel.: 310-268-4357. E-mail address:(C.H. Hinkin)
    • ,
  • S.A Castellon

      Affiliations

    • Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, 760 Westwood Plaza, Room C8-747, Los Angeles, CA 90024, USA
    • ,
  • J.H Atkinson

      Affiliations

    • Psychiatry Service, VA San Diego Healthcare System & Department of Psychiatry, University of California, San Diego, CA, USA
    • ,
  • K Goodkin

      Affiliations

    • Departments of Psychiatry and Behavioral Sciences and of Neurology, University of Miami School of Medicine, Miami, FL, USA
    • Department of Psychology, University of Miami, Coral Gables, FL, USA

Received 24 July 2001 ,Revised 17 August 2001 ,Accepted 17 August 2001.

References 

  1. Atkinson JH, Grant I, Kennedy CJ, Richman DD, Spector SA, McCutchan JA. Prevalence of psychiatric disorders among men infected with human immunodeficiency virus. Arch Gen Psychiatry. 1988;45:859–864
  2. Castellon SA, Hinkin CH, Myers HF. Neuropsychiatric disturbance is associated with executive dysfunction in HIV-1 infection. J Int Neuropsychol Soc. 2000;6:336–347
  3. Dew MA, Becker JT, Sanchez J, Caldararo R, Lopez OL, Wess J, et al.  Prevalence and predictors of depressive, anxiety, and substance use disorders in HIV-infected and uninfected men (a longitudinal evaluation). Psychol Med. 1997;27:395–409
  4. Goodkin K, Blaney NT, Tuttle RS, Nelson RH. Bereavement and HIV infection. Int Rev Psychiatry. 1996;8(2–3):201–216
  5. Perry SW. HIV-related depression. In:  Price RW,  Perry SW editor. HIV, AIDS and the brain. New York: Raven Press; 1994;p. 223–238
  6. Rabkin JG, Ferrando SJ, Jacobsberg LB, Fishman B. Prevalence of Axis I disorders in an AIDS cohort (a cross-sectional, controlled study). Comp Psychiatry. 1997;38:146–154
  7. Goodkin K, Blaney NT, Feaster D. A randomized controlled trial of a bereavement support group intervention in human immunodeficiency virus type 1-seropositive and seronegative homosexual men. Arch Gen Psychiatry. 1999;55:52–59
  8. Hinkin CH, Castellon SA, van Gorp W, Satz P. Neuropsychological features of HIV disease. In:  van Gorp WG,  Buckingham SL editor. A mental health practitioner's guide to the neuropsychiatric complications of HIV/AIDS. New York: Oxford University Press; 1998;p. 1–41
  9. Kalichman SC, Sikkema KJ. Psychological sequelae of HIV infection and AIDS (review of empirical findings). Clin Psychol Rev. 1994;14:611–632
  10. Kalichman SC, Kelly JA, Johnson JR, Bulto M. Factors associated with risk of HIV infection among chronic mentally ill adults. Am J Psychiatry. 1994;151:221–227
  11. Judd F, Mijch A, McCausland J, Cockram A. Depressive symptoms in patients with HIV infection (a further exploration). Aust NZ J Psychiatry. 1997;31:862–868
  12. Satz P, Myers HF, Maj M, Fawzy F, Forney DL, Bing EG, et al.  Depression, substance use and sexual orientation as co-factors in HIV-1 infected men (cross-cultural comparisons). NIDA Res Monogr. 1997;172:130–155
  13. Bix BC, Glosser G, Holmes W, Ballas C, Meritz M, Hutelmeyer C, et al.  Relationship between psychiatric disease and neuropsychological impairment in HIV seropositive individuals. J Int Neuropsychol Soc. 1995;1:581–588
  14. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–571
  15. Hamilton M. A rating scale for depression. J Neurol Neurosurg. 1960;23:56–61
  16. Lyketsos CG, Schwartz J, Fishman M, Treisman G. AIDS mania. J Neuropsychiatr Clin Neurosci. 1997;9:277–280
  17. Mijch AM, Judd FK, Lyketsos CG, Ellen S, Cockram A. Secondary mania in patients with HIV infection (are antiretrovirals protective?). J Neuropsychiatr Clin Neurosci. 1999;11:475–480
  18. Perretta P, Akiskal HS, Nisita C, Lorenzetti C, Zaccagnini E, Della Santa M, et al.  The high prevalence of bipolar II and associated cyclothymic and hyperthymic temperaments in HIV patients. J Affect Disord. 1998;50:215–224
  19. Halman MH, Worth JL, Sanders KM, Renshaw PF, Murray GB. Anticonvulsant use in the treatment of manic syndromes in patients with HIV-1 infection. J Neuropsychiatr Clin Neurosci. 1993;5:430–434
  20. Lyketsos CG, Treisman GJ. Mood disorders in HIV infection. Psychiatr Ann. 2001;31:45–49
  21. Sewell MC, Goggin KJ, Rabkin JG, Ferrando SJ, McElhiney MC, Evans S. Anxiety syndromes and symptoms among men with AIDS (a longitudinal controlled study). Psychosomatics. 2000;41:294–300
  22. Catania JA, Turner HA, Choi K, Coates TJ. Coping with death anxiety (help-seeking and social support among gay men with various HIV diagnoses). AIDS. 1992;6:999–1005
  23. Kelly B, Raphael B, Judd F, Perdices M, Kernutt G, Burnett P, et al.  Posttraumatic stress disorder in response to HIV infection. Gen Hosp Psychiatry. 1998;20:345–352
  24. Kimerling R, Calhoun KS, Forehand R, Armistead L, Morse E, Clark R, et al.  Traumatic stress in HIV-infected women. AIDS Educ Prev. 1999;11:321–330
  25. Cournos F, Empfiled M, Horwath E, McKinnon K, Meyer I, Schrage H, et al.  HIV seroprevalence among patients admitted to two psychiatric hospitals. Am J Psychiatry. 1991;18:1225–1230
  26. Grant I, Atkinson JH. Neuropsychiatric aspects of HIV infection and AIDS. In:  Sadock BJ,  Sadock VA editor. Comprehensive textbook of psychiatry. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2000;p. 308–336
  27. Sewell DD, Jeste DV, Atkinson JH, Heaton RK, Hesselink JR, Wiley C, et al.  HIV-associated psychosis (a study of 20 cases). Am J Psychiatry. 1994;151(2):237–242
  28. Marin RS. Apathy (a neuropsychiatric syndrome). J Neuropsychiatr Clin Neurosci. 1991;3:243–254
  29. Castellon SA, Hinkin CH, Wood S, Yarema K. Apathy, depression, and cognitive performance in HIV-1 infection. J Neuropsychiatr Clin Neurosci. 1998;10:320–329
  30. Rabkin JG, Ferrando SJ, van Gorp WV, Rieppi R, McElhiney M, Sewell M. Relationships among apathy, depression, and cognitive impairment in HIV/AIDS. J Neuropsychiatr Clin Neurosci. 2000;12:451–457
  31. Levy ML, Cummings JL, Fairbanks LA, Masterman D, Miller BL, Craig AH, et al.  Apathy is not depression. J Neuropsychiatr Clin Neurosci. 1998;10:314–319
  32. Marin R. Apathy-who cares? An introduction to apathy and related disorders of diminished motivation. Psychiatr Ann. 1997;27:18–23
  33. Cummings J. Frontal–subcortical circuits and human behavior. Arch Neurol. 1993;50:873–880
  34. Heilman KM, Bowers D, Valenstein E. Emotional disorders associated with neurological diseases. In:  Heilman KM,  Valenstein E editor. Clinical neuropsychology. 3rd ed. New York: Oxford University Press; 1993;p. 461–497
  35. Centers for Disease Control and Prevention . AIDS associated with injecting-drug use (United States, 1995). Morb Mortal Wkly Rep. 1996;45(19):392–398
  36. Kral AH, Bluthenthal RN, Booth RE, Watters JK. HIV seroprevalence among street-recruited injection drug and crack cocaine users in 16 U.S. municipalities. Am J Public Health. 1998;88:108–113
  37. Tortu S, Beardsley M, Deren S, Williams M, McCoy H, Stark M, et al.  HIV infection and patterns of risk among women drug injectors and crack cocaine users in low and high seroprevalence sites. AIDS Care. 2000;12:65–76
  38. Cabaj R. Substance abuse and HIV diseases (entwined and intimate entities). In:  McCance-Katz EF,  Kosten TR editor. New treatments for chemical addictions. Washington, DC: American Psychiatric Press; 1998;p. 113–149
  39. Ferrando S, Goggin K, Sewell M, Evans S, Fishman B, Rabkin J. Substance use disorders in gay/bisexual men with HIV and AIDS. Am J Addict. 1998;7(1):51–60
  40. Johnson JG, Rabkin JG, Lipsitz JD, Williams JB, Remien RH. Recurrent major depressive disorder among human immunodeficiency virus-positive and HIV-negative intravenous drug users (findings from a 3-year longitudinal study). Comp Psychiatry. 1999;40:31–34
  41. Ostrow DG. Substance abuse and HIV infection. Psychiatr Clin North Am. 1994;17:69–89
  42. Perry S, Jacobsberg L, Fishman B. Suicidal ideation and HIV testing. JAMA. 1990;263:675–679
  43. Rabkin JG, Wagner GJ, Rabkin R. Fluoxetine treatment for depression in patients with HIV and AIDS (a randomized, placebo-controlled trial). Am J Psychiatry. 1999;156:101–107
  44. Zisook S, Peterkin J, Goggin KJ, Sledge P, Atkinson JH, Grant I. Treatment of major depression in HIV-seropositive men. J Clin Psychiatry. 1998;59:217–224
  45. Castellon SA, Hinkin CH, Lam M, Hardy D, Stefaniak M. Neuropsychiatric disturbance and medication adherence in HIV-1 infection. Poster at the 3rd annual conference on AIDS research in California and the 17th annual University of California's universitywide AIDS research program meeting; 2000 February 25; San Francisco, CA.
  46. Hinkin CH. Neuropsychological performance and medication adherence among older HIV infected adults. Invited address to the National Institute on Aging special workshop on Aging and AIDS, 2000, Washington, DC.
  47. Compton WM, Cottler LB, Ben-Abdallah A, Cunningham-Williams R, Spitznagel EL. The effects of psychiatric comorbidity on response to an HIV prevention intervention. Drug Alcohol Depend. 2000;58:247–257
  48. Goodkin K, Feaster DJ, Tuttle R, Blaney NT, Kumar M, Baum MK, et al.  Bereavement is associated with time-dependent decrements in cellular immune function in asymptomatic HIV-1 seropositive homosexual men. Clin Diagn Lab Immunol. 1996;3:109–118
  49. Kemeny ME, Dean L. Effects of AIDS-related bereavement on HIV progression among New York City gay men. AIDS Educ Prev. 1995;7:36–47
  50. Kemeny ME, Weiner H, Duran R, Taylor SE, Visscher B, Fahey JL. Immune system changes after the death of a partner in HIV-positive gay men. Psychosom Med. 1995;57:547–554
  51. Goodkin K, Feaster DJ, Asthana D. A bereavement support group intervention is longitudinally associated with salutary effects on the CD4 cell count and on number of physician visits. Clin Diagn Lab Immunol. 1998;5:382–391
  52. Goodkin K, Baldewicz TT, Asthana D, Khamis I, Blaney NT, Kumar M, et al.  A bereavement support group intervention affects plasma burden of human immunodeficiency virus type 1. Report of a randomized clinical trial. J Hum Virol. 2001;4(1):44–54
  53. Low-Beer S, Chan K, Yip B, Wood E, Montaner JS, O'Shaughnessy MV, et al.  Depressive symptoms decline among persons on HIV protease inhibitors. J Acquir Immune Defic Syndr. 2000;23:295–301
  54. Heaton RK, Grant I, Butters N, White DA, Kirson D, Atkinson JH, et al.  The hnrc 500 (neuropsychology of hiv infection at different disease stages). J Int Neuropsychol Soc. 1995;1:231–245
  55. Hinkin CH, van Gorp WG, Satz P. Neuropsychological and neuropsychiatric aspects of HIV infection in adults. In:  Kaplan HI,  Saddock BJ editor. Comprehensive textbook of psychiatry. Vol. 6. Baltimore, MD: Williams and Wilkins; 1995;p. 1669–1680
  56. American Academy of Neurology . Nomenclature and research case definitions for neurological manifestations of human immunodeficiency virus Type-1 (HIV-1) infection. Neurology. 1991;41:778–785
  57. Grant I, Marcotte TD, Heaton RK, HNRC Group, San Diego, CA . Neurocognitive complications of HIV disease. Psychol Sci. 1999;10(3):191–195
  58. McArthur JC, Hoover DR, Bacellar H, Miller EN, Cohen BA, Becker JT, et al.  Dementia in AIDS patients (incidence and risk factors). Neurology. 1993;43:2245–2252
  59. Wilkie FL, Eisdorfer C, Morgan R, Loewenstein DA, Szapocznik J. Cognition in early Human Immunodeficiency Virus infection. Arch Neurol. 1990;47:433–440
  60. White DA, Heaton RK, Monsch AU. Neuropsychological studies of asymptomatic human immunodeficiency virus-Type 1 infected individuals. J Int Neuropsychol Soc. 1995;1:304–315
  61. Aylward EH, Brettschneider PD, McArthur JC, Harris GJ, Schlaepfer TE, Henderer JD, et al.  Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia. Am J Psychiatry. 1995;152:987–994
  62. Chang L, Ernst T, Leonido-Yee M, Speck O. Perfusion MRI detects rCBF abnormalities in early stages of HIV-cognitive motor complex. Neurology. 2000;54:389–396
  63. Hinkin CH, van Gorp WG, Mandelkern MA, Gee M, Satz P, Holston S, et al.  Cerebral metabolic change in patients with AIDS (report of a six month follow-up using positron emission tomography). J Neuropsychiatr Clin Neurosci. 1995;7:180–187
  64. Everall IP, Luthert PJ, Lantos PL. Neuronal loss in the frontal cortex in HIV infection. Lancet. 1991;337:1119–1121
  65. Navia BA, Cho ES, Petito CK, Price RW. The AIDS dementia complex II (neuropathology). Ann Neurol. 1986;19:525–535
  66. Regier D, Farmer ME, Rae DS, Myers FK, Myers JK, Kramer M, et al.  One-month prevalence of mental disorders in the United States and sociodemographic characteristics (the Epidemiologic Catchment Area Study). Acta Psychiatr Scand. 1993;88:35–47
  67. Hinkin CH, Castellon SA, Dickson-Fuhrman E, Daum G, Jaffe J, Jarvik, L. Screening for drug and alcohol abuse among older adults using the modified CAGE. Am J Addict, in press.
  68. Alexopoulos GS. Methodology of treatment studies in geriatric depression. Am J Geriatr Psychiatry. 1995;3(4):280–289
  69. Hardy DJ, Satz P, Stefaniak M, van Gorp WG, Hinkin CH, Stenquist PK. Cognition in older adults with AIDS. Poster presented at the fourth annual research conference on aging at the University of California, Los Angeles, 1999, Los Angeles, CA.
  70. Goodkin K, Wilkie FL, Tyll M, Zheng WL, Khamis I, Cohen J. Age, cognitive-motor impairment and disorder and functional status in HIV infection. Annual Meeting of the American Psychiatric Association, Chicago, IL, 2000. p. 170.
  71. Janssen RS, Nwanyanwu OC, Selik RM, Stehr-Green JK. Epidemiology of human immunodeficiency virus encephalopathy in the United States. Neurology. 1992;42:1472–1476
  72. Hinkin CH, Castellon SA. Psychological aspects of HIV infection among older adults. Invited address to the Veterans with HIV/AIDS Cohort Study (VACS) Planning Meeting, Pittsburgh, PA, 2000.

PII: S0895-4356(01)00446-2

Journal of Clinical Epidemiology
Volume 54, Issue 12, Supplement 1 , Pages S44-S52 , December 2001

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