Aging and neuro-AIDS conditions and the changing spectrum of HIV-1-associated morbidity and mortality

Goodkin, K.; Wilkie, F.L.; Concha, M.; Hinkin, C.H.; Symes, S.; Baldewicz, T.T.; Asthana, D.; Fujimura, R.K.; Lee, D.; van Zuilen, M.H.; Khamis, I.; Shapshak, P.; Eisdorfer, C.

« Previous Next »Journal of Clinical Epidemiology
Volume 54, Issue 12, Supplement 1 , Pages S35-S43, December 2001

Aging and neuro-AIDS conditions and the changing spectrum of HIV-1-associated morbidity and mortality

K. Goodkin
- Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, #803-A, Miami, FL 33136, USA
- Department of Neurology, University of Miami School of Medicine, Miami, FL, USA
- Department of Psychology, University of Miami, Coral Gables, FL, USA
- Corresponding author. Tel.: 305-243-6206; fax: 305-243-4062. E-mail address:(K. Goodkin)
F.L. Wilkie
- Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, #803-A, Miami, FL 33136, USA
M. Concha
- Department of Neurology, University of Miami School of Medicine, Miami, FL, USA
C.H. Hinkin
- Department of Psychiatry and Behavioral Sciences, University of California at Los Angeles School of Medicine, Los Angeles, CA, USA
S. Symes
- Department of Internal Medicine, University of Miami School of Medicine, Miami, FL, USA
T.T. Baldewicz
- Department of Virology, PharmaResearch Corp., Morrisville, NC, USA
D. Asthana
- Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, #803-A, Miami, FL 33136, USA
R.K. Fujimura
- Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, #803-A, Miami, FL 33136, USA
D. Lee
- Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, #803-A, Miami, FL 33136, USA
M.H. van Zuilen
- Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, #803-A, Miami, FL 33136, USA
- Department of Psychology, University of Miami, Coral Gables, FL, USA
I. Khamis
- Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, #803-A, Miami, FL 33136, USA
P. Shapshak
- Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, #803-A, Miami, FL 33136, USA
- Department of Neurology, University of Miami School of Medicine, Miami, FL, USA
- Department of Pathology, University of Miami School of Medicine, Miami, FL, USA
C. Eisdorfer
- Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, #803-A, Miami, FL 33136, USA

Received 24 July 2001; received in revised form 17 August 2001; accepted 17 August 2001.

Abstract

Older individuals (>50 years of age) now comprise over 11% of patients with AIDS in the United States. This percentage is expected to continue to grow, due both to the improved longevity of patients prescribed highly active antiretroviral therapy (HAART) and to new infections among older individuals. This review focuses on the neuropsychiatric and neurological conditions that are most likely to be affected by advancing age—HIV-1-associated cognitive–motor disorder, peripheral neuropathy, progressive multifocal leukoencephalopathy, primary CNS lymphoma, and risk for cerebrovascular accident. Age associations with incidence of these disorders and with treatment foci are specified. Implications for future changes in management are discussed.

Keywords: Aging, HIV-1 associated morbidity, Mortality, Neuro-AIDS conditions