Journal of Clinical Epidemiology
Volume 54, Issue 1 , Pages 51-57, January 2001

Prospective association of lipoprotein(a) concentrations and apo(a) size with coronary heart disease among men in the Multiple Risk Factor Intervention Trial

  • Rhobert W Evans

      Affiliations

    • Both authors contributed equally.
    • Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    • Corresponding Author InformationCorresponding author
    • ,
  • Ofer Shpilberg

      Affiliations

    • Both authors contributed equally.
    • Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    • ,
  • B.Jessica Shaten

      Affiliations

    • MRFIT Coordinating Center, Division of Biostatistics, University of Minnesota, Minneapolis, MN 55414-3080, USA
    • ,
  • Shabnam Ali

      Affiliations

    • Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    • ,
  • M.Ilyas Kamboh

      Affiliations

    • Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    • ,
  • Lewis H Kuller

      Affiliations

    • Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA

Received 5 January 1999; received in revised form 4 April 2000; accepted 12 April 2000.

Abstract 

In this nested case-control study, lipoprotein (a) [Lp(a)] concentrations and apo(a) isoform size were measured in serum samples obtained from men participating in the prospective Multiple Risk Factor Intervention Trial (MRFIT). Serum from men aged 35 to 57 years and stored for up to 20 years were analyzed for Lp(a) levels (n=736) and isoform size (n=487), respectively. Cases involved nonfatal myocardial infarctions (MI; n=98), documented during the active phase of the study that ended on February 28, 1982 and coronary heart disease (CHD) deaths (n=148) monitored through 1990. Median Lp(a) levels did not differ between cases and controls and mean apo(a) size did not vary between cases and controls in the entire study population. When adjusted for age and Lp(a) concentration, logistic regression analysis indicated that small apo(a) isoforms were associated with CHD deaths among smokers (OR 3.31; 95% CI 1.07–10.28).

Keywords:  Lipoprotein(a), Isoform, Cardiovascular disease, MRFIT, Prospective

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PII: S0895-4356(00)00260-2

Journal of Clinical Epidemiology
Volume 54, Issue 1 , Pages 51-57, January 2001

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