Journal of Clinical Epidemiology
Volume 49, Issue 2 , Pages 263-266 , February 1996

Self-reported allergy, infection, and autoimmune diseases among men and women exposed in utero to diethylstilbestrol

  • Donna Day Baird

      Affiliations

    • Corresponding Author InformationAll correspondence should be addressed to: Donna Day Baird, PhD, Epidemiology Branch, A3-05, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, U.S.A..
    • National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 U.S.A.
    • ,
  • Allen J. Wilcox

      Affiliations

    • National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 U.S.A.
    • ,
  • Arthur L. Herbst

      Affiliations

    • Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, U.S.A.

Received 18 January 1995

References 

  1. Herbst AL, Ulfelder H, Poskanzer DC. Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appearance in young women. New Engl J Med. 1971;284:878–881
  2. Kaufman RH, Binder GL, Gray PM, Adam E. Upper genital tract changes associated with exposure in utero to diethylstilbestrol. Am J Obstet Gynecol. 1977;128:51–59
  3. Gill WB, Schumacher GFB, Bibbo M, et al.  Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities. J Urol. 1979;122:36–39
  4. Gill WB. Effects on human males of in utero exposure to exogenous sex hormones. In:  Mori T,  Nagasawa H editor. Toxicity of Hormones in Perinatal Life. Boca Raton, FL: CRC Press; 1989;p. 161–177
  5. Senekjian EK, Potkul RK, Frey K, Herbst AL. Infertility among daughters either exposed or not exposed to diethylstilbestrol. Am J Obstet Gynecol. 1988;158:493–498
  6. Herbst AL, Senekjian EK, Frey K. Abortion and pregnancy loss among diethylstilbestrol-exposed women. In: 3rd ed. Semin Reprod Endocrinol. 7:1989;p. 124–129
  7. Blair PB. Immunologic consequences of early exposure of experimental rodents to diethylstilbestrol and steroid hormones. In:  Herbst AL,  Bern HA editor. Developmental Effects of Diethylstilbestrol (DES) in Pregnancy. New York: Thieme-Stratton; 1981;p. 167–178
  8. Dean JH, Luster MI, Boorman GA, Lauer LD. Procedures available to examine the immunotoxicity of chemicals and drugs. Pharmacol Rev. 1982;34:137–148
  9. Kalland T. Long-term effects on the immune system of an early life exposure to diethylstilbestrol. In: Environmental Factors in Human and Growth Development. 3rd ed.  Hunt V,  Smith MK,  Worth D editor. Banbury Report 11. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1982;p. 217–239
  10. Luster MI, Pfeifer RW, Tucker AN. Influence of sex hormones on immunoregulation with specific reference to natural and environmental estrogens. In:  Thomas JA,  Korach KS,  McLachlan JA editor. Endocrine Toxicology. New York: Raven; 1985;p. 67–83
  11. Luster MI, Faith RE, McLachlan JA. Alterations of the antibody response following in utero exposure to diethylstilbestrol. Bull Environ Contam Toxicol. 1978;20:433–437
  12. Ford CD, Johnson GH, Smith WG. Natural killer cells in in utero diethylstilbestrol-exposed patients. Gynecol Oncol. 1983;16:400–404
  13. Ways SC, Mortola JF, Zvaifler NJ, et al.  Alterations in immune responsiveness in women exposed to diethylstilbestrol in utero. Fertil Steril. 1987;48:193–197
  14. Noller KL, Blair PB, O'Brien PC, et al.  Increased occurrence of autoimmune disease among women exposed in utero to diethylstilbestrol. Fertil Steril. 1988;49:1080–1082
  15. Dieckmann WJ, Davis ME, Rynkiewicz LM, Pottinger RE. Does the administration of diethylstilbestrol during pregnancy have therapeutic value?. Am J Obstet Gynecol. 1953;66:1062–1075
  16. Holladay SD, Blaylock BL, Comment CE, et al.  Selective prothymocyte targeting by prenatal diethylstilbestrol exposure. Cell Immunol. 1993;152:131–142
  17. Patten BM. 1968 Human Embryology. In: 3rd ed. New York: McGraw-Hill; 1968;p. 438–439

☆ This reaserch was supported by NIH intramural reaserch funds.

PII: 0895-4356(95)00521-8

Journal of Clinical Epidemiology
Volume 49, Issue 2 , Pages 263-266 , February 1996

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